{"id":"https://openalex.org/W1976200049","doi":"https://doi.org/10.1074/jbc.m808593200","title":"Biochemical, Functional, and Pharmacological Characterization of AT-56, an Orally Active and Selective Inhibitor of Lipocalin-type Prostaglandin D Synthase","display_name":"Biochemical, Functional, and Pharmacological Characterization of AT-56, an Orally Active and Selective Inhibitor of Lipocalin-type Prostaglandin D Synthase","publication_year":2009,"publication_date":"2009-01-09","ids":{"openalex":"https://openalex.org/W1976200049","doi":"https://doi.org/10.1074/jbc.m808593200","mag":"1976200049","pmid":"https://pubmed.ncbi.nlm.nih.gov/19131342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2658056"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m808593200","doi":"https://doi.org/10.1074/jbc.m808593200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m808593200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m808593200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035407022","display_name":"Daisuke Irikura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisuke Irikura","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008798441","display_name":"Kosuke Aritake","orcid":"https://orcid.org/0000-0002-7441-7955","observed_orcids":["https://orcid.org/0000-0002-7441-7955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kosuke Aritake","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042778004","display_name":"Nanae Nagata","orcid":"https://orcid.org/0000-0002-5880-3979","observed_orcids":["https://orcid.org/0000-0002-5880-3979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nanae Nagata","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109216621","display_name":"Toshihiko Maruyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshihiko Maruyama","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000273424","display_name":"Shigeru Shimamoto","orcid":"https://orcid.org/0000-0002-9470-0352","observed_orcids":["https://orcid.org/0000-0002-9470-0352"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Shimamoto","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113616205","display_name":"Yoshihiro Urade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yoshihiro Urade","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113616205"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.733,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.92098516,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"284","issue":"12","first_page":"7623","last_page":"7630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipocalin-type-prostaglandin-d-synthase","display_name":"lipocalin-type prostaglandin D synthase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/prostaglandin-d2","display_name":"prostaglandin D2","score":0.7990000247955322},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hematopoietic-prostaglandin-d-synthase","display_name":"hematopoietic prostaglandin D synthase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.5830000042915344},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.621999979019165},{"id":"https://openalex.org/keywords/eosinophil-accumulation","display_name":"eosinophil accumulation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.6460000276565552},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6620933413505554},{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.641858696937561},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5616750717163086},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.5375738739967346},{"id":"https://openalex.org/C2777361909","wikidata":"https://www.wikidata.org/wiki/Q419750","display_name":"Prostaglandin D2","level":3,"score":0.5168667435646057},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.4594046175479889},{"id":"https://openalex.org/C173202427","wikidata":"https://www.wikidata.org/wiki/Q408575","display_name":"Thromboxane-A synthase","level":4,"score":0.4372609257698059},{"id":"https://openalex.org/C2909310144","wikidata":"https://www.wikidata.org/wiki/Q7553358","display_name":"Phenylbutyrate","level":2,"score":0.4328967034816742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4129677414894104},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.4011729061603546},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39733126759529114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3581553101539612},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34972554445266724},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3047052025794983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20158228278160095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09823176264762878}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014951","descriptor_name":"Wounds, Stab","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014951","descriptor_name":"Wounds, Stab","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014951","descriptor_name":"Wounds, Stab","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015230","descriptor_name":"Prostaglandin D2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m808593200","doi":"https://doi.org/10.1074/jbc.m808593200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m808593200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2658056","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2658056/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2658056/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:19131342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19131342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m808593200","doi":"https://doi.org/10.1074/jbc.m808593200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m808593200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G234051212","display_name":null,"funder_award_id":"19590094","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320310723","display_name":"Japan Foundation for Applied Enzymology","ror":"https://ror.org/0293d8d10"},{"id":"https://openalex.org/F4320311653","display_name":"Taiho Pharmaceutical","ror":"https://ror.org/02v50dx14"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320325453","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976200049.pdf","grobid_xml":"https://content.openalex.org/works/W1976200049.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1044141471","https://openalex.org/W1496585919","https://openalex.org/W1510860449","https://openalex.org/W1511203783","https://openalex.org/W1554005852","https://openalex.org/W1565847282","https://openalex.org/W1680932833","https://openalex.org/W1841242073","https://openalex.org/W1883680853","https://openalex.org/W1965946053","https://openalex.org/W1976219478","https://openalex.org/W1977147294","https://openalex.org/W1986339757","https://openalex.org/W1989624036","https://openalex.org/W1992474575","https://openalex.org/W1995533728","https://openalex.org/W1996390166","https://openalex.org/W1998702348","https://openalex.org/W1999183933","https://openalex.org/W1999344041","https://openalex.org/W2008746494","https://openalex.org/W2013190602","https://openalex.org/W2015066288","https://openalex.org/W2017888024","https://openalex.org/W2019758463","https://openalex.org/W2028539858","https://openalex.org/W2030056030","https://openalex.org/W2039058968","https://openalex.org/W2046418478","https://openalex.org/W2058118307","https://openalex.org/W2069201530","https://openalex.org/W2078858006","https://openalex.org/W2081225918","https://openalex.org/W2081353150","https://openalex.org/W2084624382","https://openalex.org/W2087936588","https://openalex.org/W2088146922","https://openalex.org/W2091134090","https://openalex.org/W2099021510","https://openalex.org/W2103017931","https://openalex.org/W2105226990","https://openalex.org/W2107831205","https://openalex.org/W2113826561","https://openalex.org/W2130414223","https://openalex.org/W2138498116","https://openalex.org/W2154004234","https://openalex.org/W2154439612","https://openalex.org/W2154922304","https://openalex.org/W2165345529","https://openalex.org/W2166893697","https://openalex.org/W2412213799","https://openalex.org/W2473130196"],"related_works":["https://openalex.org/W2949552092","https://openalex.org/W2950321735","https://openalex.org/W2612077326","https://openalex.org/W1976219478","https://openalex.org/W2052398444","https://openalex.org/W1486211103","https://openalex.org/W7100797618","https://openalex.org/W1982879708","https://openalex.org/W2584225880","https://openalex.org/W1999183933"],"abstract_inverted_index":{"We":[0],"report":[1],"here":[2],"that":[3,93],"4-dibenzo[a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine":[4],"(AT-56)":[5],"is":[6],"an":[7,126],"orally":[8],"active":[9],"and":[10,23,44,46,139,187,189,196],"selective":[11],"inhibitor":[12],"of":[13,38,71,80,104,110,129,137,169,185,194,209],"lipocalin-type":[14],"prostaglandin":[15],"(PG)":[16],"D":[17],"synthase":[18,41],"(L-PGDS).":[19],"AT-56":[20,50,94,106,155],"inhibited":[21,51,107],"human":[22,114,151,210],"mouse":[24],"L-PGDSs":[25],"in":[26,55,166,177,198],"a":[27,56,68,83,173,178],"concentration":[28],"(3-250":[29],"microm)-dependent":[30],"manner":[31,58,180],"but":[32,74,99,141],"did":[33,75],"not":[34,76,100],"affect":[35],"the":[36,52,60,78,96,101,108,146,161,167,183,192,199,204],"activities":[37],"hematopoietic":[39],"PGD":[40],"(H-PGDS),":[42],"cyclooxygenase-1":[43],"-2,":[45],"microsomal":[47],"PGE":[48],"synthase-1.":[49],"L-PGDS":[53],"activity":[54],"competitive":[57],"against":[59],"substrate":[61],"PGH(2)":[62],"(K(m)":[63],"=":[64],"14":[65],"microm)":[66],"with":[67,119,125],"K(i)":[69],"value":[70,128],"75":[72],"microm":[73,123,132],"inhibit":[77],"binding":[79],"13-cis-retinoic":[81],"acid,":[82],"nonsubstrate":[84],"lipophilic":[85],"ligand,":[86],"to":[87,164],"L-PGDS.":[88,105],"NMR":[89],"titration":[90],"analysis":[91],"revealed":[92],"occupied":[95],"catalytic":[97],"pocket,":[98,103],"retinoid-binding":[102],"production":[109,136,148,163,184],"PGD(2)":[111,147,162],"by":[112,149],"L-PGDS-expressing":[113],"TE-671":[115],"cells":[116],"after":[117,172],"stimulation":[118],"Ca(2+)":[120],"ionophore":[121],"(5":[122],"A23187)":[124],"IC(50)":[127],"about":[130],"3":[131],"without":[133,181],"affecting":[134,182],"their":[135],"PGE(2)":[138,186],"PGF(2alpha)":[140,188],"had":[142],"no":[143],"effect":[144],"on":[145],"H-PGDS-expressing":[150],"megakaryocytes.":[152],"Orally":[153],"administered":[154],"(<30":[156],"mg/kg":[157],"body":[158],"weight)":[159],"decreased":[160],"40%":[165],"brain":[168],"H-PGDS-deficient":[170],"mice":[171],"stab":[174],"wound":[175],"injury":[176],"dose-dependent":[179],"also":[190],"suppressed":[191],"accumulation":[193],"eosinophils":[195],"monocytes":[197],"bronco-alveolar":[200],"lavage":[201],"fluid":[202],"from":[203],"antigen-induced":[205],"lung":[206],"inflammation":[207],"model":[208],"L-PGDS-transgenic":[211],"mice.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
