{"id":"https://openalex.org/W1976127384","doi":"https://doi.org/10.1096/fj.10-154690","title":"Polylactide\u2010cyclosporin A nanoparticles for targeted immunosuppression","display_name":"Polylactide\u2010cyclosporin A nanoparticles for targeted immunosuppression","publication_year":2010,"publication_date":"2010-06-14","ids":{"openalex":"https://openalex.org/W1976127384","doi":"https://doi.org/10.1096/fj.10-154690","mag":"1976127384","pmid":"https://pubmed.ncbi.nlm.nih.gov/20547662","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2996919"},"language":"en","primary_location":{"id":"doi:10.1096/fj.10-154690","doi":"https://doi.org/10.1096/fj.10-154690","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.10-154690","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2996919","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043563275","display_name":"Jamil R. Azzi","orcid":"https://orcid.org/0000-0002-6909-4645","observed_orcids":["https://orcid.org/0000-0002-6909-4645"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamil Azzi","raw_affiliation_strings":["Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065125027","display_name":"Li Tang","orcid":"https://orcid.org/0000-0002-6393-982X","observed_orcids":["https://orcid.org/0000-0002-6393-982X","https://orcid.org/0000-0002-6776-1846"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Tang","raw_affiliation_strings":["Department of Materials Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois US","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103085563","display_name":"Robert F. Moore","orcid":"https://orcid.org/0000-0002-6884-9655","observed_orcids":["https://orcid.org/0000-0002-6884-9655"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Moore","raw_affiliation_strings":["Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047323439","display_name":"Rong Tong","orcid":"https://orcid.org/0000-0002-2034-9272","observed_orcids":["https://orcid.org/0000-0002-2034-9272"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Tong","raw_affiliation_strings":["Department of Materials Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois US","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110262743","display_name":"Najib El Haddad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Najib El Haddad","raw_affiliation_strings":["Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110382902","display_name":"Takurin Akiyoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takurin Akiyoshi","raw_affiliation_strings":["Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044250587","display_name":"Bechara G. Mfarrej","orcid":"https://orcid.org/0000-0002-8361-5240","observed_orcids":["https://orcid.org/0000-0002-8361-5240"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bechara Mfarrej","raw_affiliation_strings":["Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102079797","display_name":"Sunmi Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunmi Yang","raw_affiliation_strings":["Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017804129","display_name":"Mollie M. Jurewicz","orcid":"https://orcid.org/0000-0001-8482-3060","observed_orcids":["https://orcid.org/0000-0001-8482-3060"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mollie Jurewicz","raw_affiliation_strings":["Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080273574","display_name":"Takaharu Ichimura","orcid":"https://orcid.org/0000-0002-3106-5224","observed_orcids":["https://orcid.org/0000-0002-3106-5224"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takaharu Ichimura","raw_affiliation_strings":["Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035004148","display_name":"Neal Ian Lindeman","orcid":"https://orcid.org/0000-0002-7092-6859","observed_orcids":["https://orcid.org/0000-0002-7092-6859"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal Lindeman","raw_affiliation_strings":["Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010902410","display_name":"Jianjun Cheng","orcid":"https://orcid.org/0000-0003-2561-9291","observed_orcids":["https://orcid.org/0000-0003-2561-9291","https://orcid.org/0009-0000-5867-8015"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianjun Cheng","raw_affiliation_strings":["Department of Materials Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois US","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023494315","display_name":"Reza Abdi","orcid":"https://orcid.org/0000-0003-4789-5422","observed_orcids":["https://orcid.org/0000-0003-4789-5422"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza Abdi","raw_affiliation_strings":["Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Transplantation Research Center Renal Division Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":2.11,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.84752951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"24","issue":"10","first_page":"3927","last_page":"3938"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.11909999698400497,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polylactide-nanoparticles","display_name":"polylactide nanoparticles","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7919999957084656},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.7940000295639038},{"id":"https://openalex.org/keywords/nanoprecipitation","display_name":"nanoprecipitation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/lymph-node-targeting","display_name":"lymph node targeting","score":0.9089999794960022},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8730000257492065},{"id":"https://openalex.org/keywords/alloreactive-t-cells","display_name":"alloreactive T cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6759999990463257},{"id":"https://openalex.org/keywords/allogeneic-dendritic-cells","display_name":"allogeneic dendritic cells","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6285309791564941},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5729759335517883},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5724350214004517},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5361521244049072},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4805893898010254},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4754859209060669},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4498528242111206},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3153594732284546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2829643487930298},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24467292428016663},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08045947551727295},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1096/fj.10-154690","doi":"https://doi.org/10.1096/fj.10-154690","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.10-154690","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2996919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2996919","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},{"id":"pmid:20547662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20547662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"pmh:oai:infoscience.epfl.ch:220743","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/220743","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:220743","doi":null,"is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/128574","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2996919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2996919","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1982765690","display_name":"CAREER:  Development of Conjugated Polymer-Drug Nanoparticulate Delivery Vehicles","funder_award_id":"0748834","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2847997948","display_name":"Docetaxel Nanoparticles for Prostate Cancer Targeting","funder_award_id":"R21CA139329","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8518767632","display_name":"Development of Functional Poly(alpha-hydroxy acids) for Drug Delivery Application","funder_award_id":"R21EB009486","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306163","display_name":"Prostate Cancer Foundation","ror":"https://ror.org/01npwtv09"},{"id":"https://openalex.org/F4320306445","display_name":"National Kidney Foundation","ror":null},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320310820","display_name":"Juvenile Diabetes Research Foundation United States of America","ror":"https://ror.org/00vqxjy61"},{"id":"https://openalex.org/F4320320617","display_name":"Roche Organ Transplant Research Foundation","ror":"https://ror.org/03cgjk195"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1505099959","https://openalex.org/W1975995257","https://openalex.org/W1979584913","https://openalex.org/W1991300039","https://openalex.org/W1996998905","https://openalex.org/W2014081236","https://openalex.org/W2015776459","https://openalex.org/W2019555018","https://openalex.org/W2024389055","https://openalex.org/W2029623098","https://openalex.org/W2029749273","https://openalex.org/W2043232628","https://openalex.org/W2046851174","https://openalex.org/W2050739406","https://openalex.org/W2056347214","https://openalex.org/W2060860123","https://openalex.org/W2062308078","https://openalex.org/W2082264584","https://openalex.org/W2089773350","https://openalex.org/W2092072880","https://openalex.org/W2106084467","https://openalex.org/W2108459965","https://openalex.org/W2110482491","https://openalex.org/W2124935141","https://openalex.org/W2126121859","https://openalex.org/W2128699224","https://openalex.org/W2136865475","https://openalex.org/W2164526800","https://openalex.org/W2166590597","https://openalex.org/W2167924652","https://openalex.org/W2169969151","https://openalex.org/W2183141883","https://openalex.org/W4211245808"],"related_works":["https://openalex.org/W7100950414","https://openalex.org/W2107756640","https://openalex.org/W7098812925","https://openalex.org/W2069095949","https://openalex.org/W2146557046","https://openalex.org/W2013112364","https://openalex.org/W2092679595","https://openalex.org/W2149040701","https://openalex.org/W2148338281","https://openalex.org/W2328198828"],"abstract_inverted_index":{"Polymeric":[0],"nanoparticles":[1],"(NPs),":[2],"prepared":[3],"via":[4],"coprecipitation":[5],"of":[6,42,79,84,149,198],"drugs":[7,200],"and":[8,21,55,60,74,82,100,104,125,204],"polymers,":[9],"are":[10,111],"promising":[11],"drug":[12],"delivery":[13,188,197],"vehicles":[14],"for":[15,30,98,115,194],"treating":[16],"diseases":[17],"with":[18,123,145,162,201],"improved":[19,202],"efficacy":[20],"reduced":[22,179,205],"toxicity.":[23,206],"Here,":[24],"we":[25,118],"report":[26],"an":[27],"unprecedented":[28],"strategy":[29],"preparing":[31],"polylactide-cyclosporine":[32],"A":[33],"(PLA-CsA)":[34],"NPs":[35],"(termed":[36],"CsA-NPs)":[37],"through":[38],"CsA-initiated":[39],"ring-opening":[40],"polymerization":[41],"lactide":[43],"(LA)":[44],"followed":[45],"by":[46],"nanoprecipitation.":[47],"The":[48,95],"resulting":[49],"CsA-NPs":[50,75,101,124,138,163],"have":[51],"sub-100":[52],"nm":[53],"sizes":[54],"narrow":[56],"particle":[57],"size":[58],"distributions,":[59],"release":[61,148],"CsA":[62,73,99,128,150,187],"in":[63,87,91,142],"a":[64,68,92,146,191],"sustained":[65,147],"manner":[66],"without":[67,180],"\"burst\"-release":[69],"effect.":[70],"Both":[71],"free":[72],"displayed":[76],"comparable":[77],"suppression":[78],"T-cell":[80,89,116,157,175],"proliferation":[81],"production":[83],"inflammatory":[85],"cytokines":[86],"various":[88],"assays":[90],"dose-dependent":[93],"manner.":[94],"IC(50)":[96],"values":[97],"were":[102,164],"27.5":[103],"72.0":[105],"ng/ml,":[106],"respectively.":[107],"As":[108],"lymph":[109,132,171],"nodes":[110,172],"the":[112,131,143,152,169,174],"main":[113],"loci":[114],"activation,":[117],"coupled":[119],"dendritic":[120],"cells":[121],"(DCs)":[122],"successfully":[126],"delivered":[127],"selectively":[129],"to":[130,151,166,168],"nodes.":[133],"Our":[134],"studies":[135],"indicated":[136],"that":[137],"could":[139],"be":[140],"internalized":[141],"DCs":[144,160],"culture":[153],"medium,":[154],"suppressing":[155],"alloreactive":[156],"proliferation.":[158],"Allogeneic":[159],"loaded":[161],"able":[165],"migrate":[167],"draining":[170],"where":[173],"priming":[176],"was":[177],"significantly":[178],"any":[181],"systemic":[182],"release.":[183],"This":[184],"innovative":[185],"nanoparticulate":[186],"technology":[189],"constitutes":[190],"strong":[192],"basis":[193],"future":[195],"targeted":[196],"immunosuppressive":[199],"efficiency":[203]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}