{"id":"https://openalex.org/W1976122011","doi":"https://doi.org/10.1021/tx8002998","title":"Interaction of Polycyclic Aromatic Hydrocarbons with Human Cytochrome P450 1B1 in Inhibiting Catalytic Activity","display_name":"Interaction of Polycyclic Aromatic Hydrocarbons with Human Cytochrome P450 1B1 in Inhibiting Catalytic Activity","publication_year":2008,"publication_date":"2008-10-23","ids":{"openalex":"https://openalex.org/W1976122011","doi":"https://doi.org/10.1021/tx8002998","mag":"1976122011","pmid":"https://pubmed.ncbi.nlm.nih.gov/19548353","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772130"},"language":"en","primary_location":{"id":"doi:10.1021/tx8002998","doi":"https://doi.org/10.1021/tx8002998","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx8002998","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2772130/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103063699","display_name":"Tsutomu Shimada","orcid":"https://orcid.org/0000-0003-2552-4348","observed_orcids":["https://orcid.org/0000-0003-2552-4348"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Tsutomu Shimada","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109999482","display_name":"Norie Murayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Norie Murayama","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032860273","display_name":"Katsuhiro Tanaka","orcid":"https://orcid.org/0000-0001-5363-1875","observed_orcids":["https://orcid.org/0000-0001-5363-1875"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Katsuhiro Tanaka","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068964571","display_name":"Shigeo Takenaka","orcid":"https://orcid.org/0009-0002-2519-9549","observed_orcids":["https://orcid.org/0009-0002-2519-9549"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shigeo Takenaka","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113651266","display_name":"Yoshio Imai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yoshio Imai","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111935151","display_name":"Nancy Eddy Hopkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Nancy E. Hopkins","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072993142","display_name":"Maryam K. Foroozesh","orcid":"https://orcid.org/0000-0001-9928-1815","observed_orcids":["https://orcid.org/0000-0001-9928-1815"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Maryam K. Foroozesh","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034961847","display_name":"Willam L. Alworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Willam L. Alworth","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078922881","display_name":"Hiroshi Yamazaki","orcid":"https://orcid.org/0000-0002-1068-4261","observed_orcids":["https://orcid.org/0000-0002-1068-4261"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroshi Yamazaki","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058389506","display_name":"Frederick Peter Guengerich","orcid":"https://orcid.org/0000-0002-7458-3048","observed_orcids":["https://orcid.org/0000-0002-7458-3048"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"F. Peter Guengerich","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111445714","display_name":"Masayuki Komori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I194120229","display_name":"Xavier University","ror":"https://ror.org/00f266q65","country_code":"US","type":"education","lineage":["https://openalex.org/I194120229"]},{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masayuki Komori","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan, Departments of Chemistry and Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, Chemistry Department, Xavier University, New Orleans, Louisiana 70125, and Department of Biochemistry and Center in","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103063699"],"corresponding_institution_ids":["https://openalex.org/I114832834","https://openalex.org/I15807432","https://openalex.org/I194120229","https://openalex.org/I8873088"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.082,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.83989671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"12","first_page":"2313","last_page":"2323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.10849999636411667,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cyp1b1","display_name":"CYP1B1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.7609999775886536},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.8889999985694885},{"id":"https://openalex.org/keywords/biphenyl","display_name":"biphenyl","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ethoxyresorufin-o-deethylation","display_name":"7-ethoxyresorufin O-deethylation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mechanism-based-inhibition","display_name":"mechanism-based inhibition","score":0.6570000052452087},{"id":"https://openalex.org/keywords/fluorescence-quenching","display_name":"fluorescence quenching","score":0.8899999856948853},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8614760637283325},{"id":"https://openalex.org/C2775982679","wikidata":"https://www.wikidata.org/wiki/Q422544","display_name":"Propynyl","level":2,"score":0.8240864276885986},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.8008229732513428},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6010663509368896},{"id":"https://openalex.org/C2780591471","wikidata":"https://www.wikidata.org/wiki/Q410915","display_name":"Biphenyl","level":2,"score":0.5371077656745911},{"id":"https://openalex.org/C2776891815","wikidata":"https://www.wikidata.org/wiki/Q422037","display_name":"Phenanthrene","level":2,"score":0.48711228370666504},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.44701069593429565},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3137975335121155},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20723241567611694}],"mesh":[{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011084","descriptor_name":"Polycyclic Aromatic Hydrocarbons","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065633","descriptor_name":"Cytochrome P-450 CYP1B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/tx8002998","doi":"https://doi.org/10.1021/tx8002998","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx8002998","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},{"id":"pmid:19548353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19548353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical research in toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2772130","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2772130/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Res Toxicol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.689.7691","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.689.7691","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772130/pdf/nihms91225.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2772130","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2772130/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Res Toxicol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1240861362","display_name":"Metabolism of Carcinogens and Drugs by Human P450s","funder_award_id":"R37CA090426","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4579577170","display_name":"Metabolism of Carcinogens and Drugs by Human P450s","funder_award_id":"R01CA090426","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5061398596","display_name":"Center in Molecular Toxicology","funder_award_id":"P30ES000267","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1519080989","https://openalex.org/W1542868541","https://openalex.org/W1775749144","https://openalex.org/W1793982695","https://openalex.org/W1802772100","https://openalex.org/W1848867726","https://openalex.org/W1871379037","https://openalex.org/W1884649498","https://openalex.org/W1951469402","https://openalex.org/W1964770503","https://openalex.org/W1968819739","https://openalex.org/W1998218758","https://openalex.org/W2002724493","https://openalex.org/W2006891717","https://openalex.org/W2007508562","https://openalex.org/W2008846594","https://openalex.org/W2016706696","https://openalex.org/W2021232512","https://openalex.org/W2026117122","https://openalex.org/W2030607204","https://openalex.org/W2032890964","https://openalex.org/W2036622715","https://openalex.org/W2039695749","https://openalex.org/W2046580571","https://openalex.org/W2050581983","https://openalex.org/W2055084808","https://openalex.org/W2060230074","https://openalex.org/W2062467703","https://openalex.org/W2067615424","https://openalex.org/W2068986290","https://openalex.org/W2071272081","https://openalex.org/W2087368546","https://openalex.org/W2108418459","https://openalex.org/W2114281295","https://openalex.org/W2124062352","https://openalex.org/W2132762752","https://openalex.org/W2158221547"],"related_works":["https://openalex.org/W2060230074","https://openalex.org/W2068986290","https://openalex.org/W1968819739","https://openalex.org/W1989553165","https://openalex.org/W2021447714","https://openalex.org/W2071272081","https://openalex.org/W1994649067","https://openalex.org/W1973848340","https://openalex.org/W2049341645","https://openalex.org/W1968749065"],"abstract_inverted_index":{"Eleven":[0],"polycyclic":[1,257],"aromatic":[2,258],"hydrocarbons":[3],"(PAHs)":[4],"and":[5,9,66,78,135,166,230,232,260,269],"14":[6],"acetylenic":[7,164],"PAHs":[8,167,261],"biphenyls":[10],"were":[11,38,86],"used":[12],"to":[13,192],"analyze":[14],"interactions":[15,191,274],"with":[16,74,88,99,132,160,170,173,186,199,227,255],"cytochrome":[17],"P450":[18,42,112,133,157,171,187,200,207,211,228,242,252,281],"(P450)":[19],"1B1":[20,43,188,201,229,253],"in":[21,147,221,262,273],"inhibiting":[22],"catalytic":[23,151],"activity,":[24],"using":[25],"7-ethoxyresorufin":[26],"O-deethylation":[27],"(EROD)":[28],"as":[29],"a":[30,47,142],"model":[31],"reaction.":[32],"Most":[33],"of":[34,41,53,56,60,69,94,150,154,156,181,183,206,224],"the":[35,51,70,104,108,117,123,136,148,222,267],"chemicals":[36,279],"examined":[37],"direct":[39,54],"inhibitors":[40,90,161,165,226,240],"except":[44],"for":[45,111,144],"4-(1-propynyl)biphenyl,":[46],"mechanism-based":[48],"inhibitor.":[49],"In":[50],"case":[52],"inhibition":[55,149],"EROD":[57,71,83,114],"activity":[58,72],"{15":[59],"24":[61],"chemicals,":[62,107,268],"e.g.,":[63],"benzo[a]pyrene,":[64],"1-(1-propynyl)pyrene,":[65],"3-(1-propynyl)phenanthrene},":[67],"restoration":[68],"occurred":[73],"increasing":[75,100],"incubation":[76,95,101],"time,":[77],"kinetic":[79],"analysis":[80],"showed":[81,189],"that":[82,163,195,216,233,251,270],"K(m)":[84,109],"values":[85,110,175],"higher":[87],"these":[89,190,234,271,278],"at":[91],"initial":[92],"stages":[93],"but":[96,121],"became":[97],"lower":[98],"time.":[102],"With":[103],"other":[105],"nine":[106],"1B1-mediated":[113],"increased":[115],"during":[116],"incubations.":[118],"Acetylenic":[119],"inhibitors,":[120],"not":[122],"11":[124],"PAHs,":[125],"induced":[126],"reverse":[127],"type":[128],"I":[129],"spectral":[130],"changes":[131],"1B1,":[134,172,208],"low":[137],"dissociation":[138],"constants":[139],"(K(s))":[140],"suggested":[141,215],"role":[143],"such":[145],"interaction":[146,223],"activity.":[152],"Studies":[153],"quenching":[155,182],"1B1-derived":[158],"fluorescence":[159,185],"demonstrated":[162],"interacted":[168,198],"rapidly":[169],"K(d)":[174],"<":[176],"10":[177],"microM.":[178],"However,":[179],"studies":[180],"inhibitor-derived":[184],"be":[193],"different,":[194],"is,":[196],"B[a]P":[197],"more":[202],"slowly.":[203],"Molecular":[204],"docking":[205],"based":[209],"on":[210,266],"1A2":[212,231],"crystal":[213],"structure,":[214],"there":[217],"are":[218],"clear":[219],"differences":[220,235,272],"PAH":[225,239],"may":[236,275],"explain":[237,276],"why":[238],"inhibit":[241,280],"1":[243],"enzymes":[244],"by":[245,283],"different":[246,263,284],"mechanisms.":[247,285],"The":[248],"results":[249],"suggest":[250],"interacts":[254],"synthetic":[256],"acetylenes":[259],"ways,":[264],"depending":[265],"how":[277],"activities":[282]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
