{"id":"https://openalex.org/W1976100975","doi":"https://doi.org/10.1007/bf00170660","title":"Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells","display_name":"Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W1976100975","doi":"https://doi.org/10.1007/bf00170660","mag":"1976100975","pmid":"https://pubmed.ncbi.nlm.nih.gov/1667331"},"language":"en","primary_location":{"id":"doi:10.1007/bf00170660","doi":"https://doi.org/10.1007/bf00170660","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00170660","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110652950","display_name":"Ingeborg van der Ploeg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ingeborg van der Ploeg","raw_affiliation_strings":["Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden","Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035066159","display_name":"Nedret Alt\u0131ok","orcid":"https://orcid.org/0000-0001-5989-8482","observed_orcids":["https://orcid.org/0000-0001-5989-8482"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Nedret Altiok","raw_affiliation_strings":["Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062354919","display_name":"Anders Kvanta","orcid":"https://orcid.org/0000-0003-2194-7490","observed_orcids":["https://orcid.org/0000-0003-2194-7490"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Kvanta","raw_affiliation_strings":["Department of Immunology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden","Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024790515","display_name":"Christer Nordstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christer Nordstedt","raw_affiliation_strings":["Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109316958","display_name":"Bertil B. Fredholm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bertil B. Fredholm","raw_affiliation_strings":["Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.2643,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.47235545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"344","issue":"5","first_page":"611","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.09950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pertussis-toxin-sensitive-g-proteins","display_name":"pertussis toxin-sensitive G proteins","score":0.9110000133514404},{"id":"https://openalex.org/keywords/gi2","display_name":"Gi2","score":0.6050000190734863},{"id":"https://openalex.org/keywords/gi3","display_name":"Gi3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/camp-accumulation","display_name":"cAMP accumulation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.9549999833106995},{"id":"https://openalex.org/keywords/phorbol-12-13-dibutyrate","display_name":"phorbol 12,13-dibutyrate","score":0.9319999814033508},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9089999794960022},{"id":"https://openalex.org/keywords/adenylyl-cyclase-inhibition","display_name":"adenylate cyclase inhibition","score":0.8289999961853027},{"id":"https://openalex.org/keywords/prostaglandin-e2-receptor","display_name":"prostaglandin E2 receptor","score":0.890999972820282},{"id":"https://openalex.org/keywords/adenosine-a2-receptor","display_name":"adenosine A2 receptor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.7960000038146973},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.6769999861717224},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.861907422542572},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.848047137260437},{"id":"https://openalex.org/C3017695315","wikidata":"https://www.wikidata.org/wiki/Q37713691","display_name":"Phorbol ester","level":4,"score":0.6435974836349487},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.59134441614151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5211208462715149},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4409908950328827},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.36830052733421326},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.35584506392478943},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.335299015045166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.286490797996521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20494866371154785},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.10646742582321167},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08928689360618591},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010566","descriptor_name":"Virulence Factors, Bordetella","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010703","descriptor_name":"Phorbol Esters","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011458","descriptor_name":"Prostaglandins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019830","descriptor_name":"Adenosine-5'-(N-ethylcarboxamide)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037342","descriptor_name":"Pertussis Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037361","descriptor_name":"Adenylate Cyclase Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00170660","doi":"https://doi.org/10.1007/bf00170660","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00170660","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},{"id":"pmid:1667331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1667331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's archives of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1489932031","https://openalex.org/W1497264238","https://openalex.org/W1528861635","https://openalex.org/W1530270875","https://openalex.org/W1535986268","https://openalex.org/W1543525864","https://openalex.org/W1562814705","https://openalex.org/W1858552878","https://openalex.org/W1965887760","https://openalex.org/W1968658549","https://openalex.org/W1975048596","https://openalex.org/W1983991788","https://openalex.org/W1991255999","https://openalex.org/W1996626314","https://openalex.org/W2001692359","https://openalex.org/W2012346665","https://openalex.org/W2015268213","https://openalex.org/W2016397692","https://openalex.org/W2018010943","https://openalex.org/W2018289835","https://openalex.org/W2029961988","https://openalex.org/W2029980242","https://openalex.org/W2032214352","https://openalex.org/W2032234708","https://openalex.org/W2032941398","https://openalex.org/W2042559451","https://openalex.org/W2043868434","https://openalex.org/W2046126244","https://openalex.org/W2052720758","https://openalex.org/W2055674941","https://openalex.org/W2058004531","https://openalex.org/W2076415696","https://openalex.org/W2078117339","https://openalex.org/W2080308076","https://openalex.org/W2080875376","https://openalex.org/W2090425905","https://openalex.org/W2095313312","https://openalex.org/W2100837269","https://openalex.org/W2102668827","https://openalex.org/W2117792349","https://openalex.org/W2128635872","https://openalex.org/W2160392761","https://openalex.org/W2416125126","https://openalex.org/W2443659675","https://openalex.org/W2467044267"],"related_works":["https://openalex.org/W2029980242","https://openalex.org/W2055674941","https://openalex.org/W2040692661","https://openalex.org/W1996470508","https://openalex.org/W2135278409","https://openalex.org/W1523098832","https://openalex.org/W1984731358","https://openalex.org/W1514664656","https://openalex.org/W2012346665","https://openalex.org/W2414716654"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}