{"id":"https://openalex.org/W1976099593","doi":"https://doi.org/10.1371/journal.pone.0035351","title":"Novel Small-Molecule Inhibitors of Hepatitis C Virus Entry Block Viral Spread and Promote Viral Clearance in Cell Culture","display_name":"Novel Small-Molecule Inhibitors of Hepatitis C Virus Entry Block Viral Spread and Promote Viral Clearance in Cell Culture","publication_year":2012,"publication_date":"2012-04-24","ids":{"openalex":"https://openalex.org/W1976099593","doi":"https://doi.org/10.1371/journal.pone.0035351","mag":"1976099593","pmid":"https://pubmed.ncbi.nlm.nih.gov/22545104","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3335862"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0035351","doi":"https://doi.org/10.1371/journal.pone.0035351","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035351","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035351&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035351&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084433298","display_name":"Glen A. Coburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Glen A. Coburn","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America. gcoburn@progenics.com","Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America. gcoburn@progenics.com","institution_ids":["https://openalex.org/I4210116119"]},{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109959752","display_name":"Danielle N. Fisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle N. Fisch","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023795529","display_name":"Sameer M. Moorji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameer M. Moorji","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040987566","display_name":"Jean-Marc de Muys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Marc de Muys","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032705889","display_name":"Jose D. Murga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose D. Murga","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dorothy Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy Paul","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091091287","display_name":"Kathleen Provoncha","orcid":"https://orcid.org/0000-0001-8491-4333","observed_orcids":["https://orcid.org/0000-0001-8491-4333"]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen P. Provoncha","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082549377","display_name":"Yakov Rotshteyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yakov Rotshteyn","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058173427","display_name":"Amy Q. Han","orcid":"https://orcid.org/0000-0001-5012-8262","observed_orcids":["https://orcid.org/0000-0001-5012-8262"]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Q. Han","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110962196","display_name":"Dapeng Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dapeng Qian","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035255731","display_name":"Paul Jay Maddon","orcid":"https://orcid.org/0000-0002-2264-6270","observed_orcids":["https://orcid.org/0000-0002-2264-6270"]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Maddon","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017367178","display_name":"William C. Olson","orcid":"https://orcid.org/0000-0001-6254-0641","observed_orcids":["https://orcid.org/0000-0001-6254-0641"]},"institutions":[{"id":"https://openalex.org/I4210116119","display_name":"Progenics Pharmaceuticals (United States)","ror":"https://ror.org/023ka9926","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Olson","raw_affiliation_strings":["Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I4210116119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084433298"],"corresponding_institution_ids":["https://openalex.org/I4210116119"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.4261,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.88090231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"4","first_page":"e35351","last_page":"e35351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/viral-entry-inhibitors","display_name":"viral entry inhibitors","score":0.871999979019165},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-to-cell-viral-spread","display_name":"cell-to-cell viral spread","score":0.8100000023841858},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.7839999794960022},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.8209999799728394},{"id":"https://openalex.org/keywords/genotype-1b","display_name":"genotype 1b","score":0.7300000190734863},{"id":"https://openalex.org/keywords/genotype-2a","display_name":"genotype 2a","score":0.7509999871253967},{"id":"https://openalex.org/keywords/viral-fitness","display_name":"viral fitness","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6786181926727295},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6397397518157959},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5913552641868591},{"id":"https://openalex.org/C2776997796","wikidata":"https://www.wikidata.org/wiki/Q1345259","display_name":"Entry inhibitor","level":5,"score":0.5901253819465637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5802935361862183},{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.5603865385055542},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.44965457916259766},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4305707514286041},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4290228486061096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12111470103263855}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0035351","doi":"https://doi.org/10.1371/journal.pone.0035351","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035351","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035351&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3335862","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3335862","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22545104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22545104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.270.2462","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.270.2462","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4c/f7/PLoS_One_2012_Apr_24_7(4)_e35351.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a9586f6cd3614cdea54f6f4f8141f1da","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a9586f6cd3614cdea54f6f4f8141f1da","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 4, p e35351 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/125874","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Novel_Small_Molecule_Inhibitors_of_Hepatitis_C_Virus_Entry_Block_Viral_Spread_and_Promote_Viral_Clearance_in_Cell_Culture/125874","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0035351","doi":"https://doi.org/10.1371/journal.pone.0035351","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035351","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035351&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2326047450","display_name":"Development of Hepatitis C Virus Inhibitors","funder_award_id":"R44AI051134","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976099593.pdf","grobid_xml":"https://content.openalex.org/works/W1976099593.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1965899699","https://openalex.org/W1967080996","https://openalex.org/W1967244561","https://openalex.org/W1968376947","https://openalex.org/W1974593063","https://openalex.org/W1975564745","https://openalex.org/W1976569781","https://openalex.org/W1977036616","https://openalex.org/W1983951850","https://openalex.org/W1986505810","https://openalex.org/W1996064622","https://openalex.org/W2004817638","https://openalex.org/W2009108547","https://openalex.org/W2012420380","https://openalex.org/W2014954855","https://openalex.org/W2015489330","https://openalex.org/W2021082528","https://openalex.org/W2029323175","https://openalex.org/W2030371794","https://openalex.org/W2043519223","https://openalex.org/W2044193462","https://openalex.org/W2044689499","https://openalex.org/W2046658390","https://openalex.org/W2047352444","https://openalex.org/W2048974214","https://openalex.org/W2049107903","https://openalex.org/W2051481258","https://openalex.org/W2053536599","https://openalex.org/W2057756365","https://openalex.org/W2062741582","https://openalex.org/W2064526034","https://openalex.org/W2072897393","https://openalex.org/W2075147482","https://openalex.org/W2096328031","https://openalex.org/W2098816844","https://openalex.org/W2100675210","https://openalex.org/W2102264941","https://openalex.org/W2108463852","https://openalex.org/W2108571089","https://openalex.org/W2124547357","https://openalex.org/W2125963799","https://openalex.org/W2129810176","https://openalex.org/W2132046473","https://openalex.org/W2134181802","https://openalex.org/W2140369033","https://openalex.org/W2141214317","https://openalex.org/W2142385013","https://openalex.org/W2143559032","https://openalex.org/W2150162776","https://openalex.org/W2167714763","https://openalex.org/W2171178957","https://openalex.org/W2317554121"],"related_works":["https://openalex.org/W2021082528","https://openalex.org/W2064629470","https://openalex.org/W128637017","https://openalex.org/W2304592771","https://openalex.org/W2464135358","https://openalex.org/W2473408999","https://openalex.org/W1996999543","https://openalex.org/W4225144691","https://openalex.org/W4233014051","https://openalex.org/W2282705120"],"abstract_inverted_index":{"Combinations":[0],"of":[1,14,40,47,56,75,85,98,112,142,169,200,217,239,259,268,275],"direct-acting":[2],"anti-virals":[3],"offer":[4],"the":[5,9,15,105,139,153,163,177,214,224,240,248,257,262],"potential":[6,280],"to":[7,146,149,223,261],"improve":[8],"efficacy,":[10],"tolerability":[11],"and":[12,71,82,95,166,171,179],"duration":[13],"current":[16],"treatment":[17,111],"regimen":[18],"for":[19,37,104,283],"hepatitis":[20],"C":[21],"virus":[22,94],"(HCV)":[23],"infection.":[24,285],"Viral":[25],"entry":[26,120,276],"represents":[27,235],"a":[28,38,52,57,73,118,132,195,203,236,279],"distinct":[29],"therapeutic":[30],"target":[31],"that":[32,78,108,131,187],"has":[33],"been":[34],"validated":[35],"clinically":[36],"number":[39],"pathogenic":[41],"viruses.":[42],"To":[43],"discover":[44],"novel":[45,281],"inhibitors":[46,84,277],"HCV":[48,63,86,99,114,180,211,218,228,260,284],"entry,":[49],"we":[50],"conducted":[51],"high":[53],"throughput":[54],"screen":[55],"proprietary":[58],"small-molecule":[59],"compound":[60],"library":[61],"using":[62],"pseudoviral":[64],"particle":[65],"(HCVpp)":[66],"technology.":[67],"We":[68,102,128],"independently":[69],"discovered":[70],"optimized":[72],"series":[74],"1,3,5-triazine":[76],"compounds":[77,89,151,271],"are":[79],"potent,":[80],"selective":[81],"non-cytotoxic":[83],"entry.":[87],"Representative":[88],"fully":[90],"suppress":[91],"both":[92,162],"cell-free":[93],"cell-to-cell":[96],"spread":[97],"in":[100,126,138,176],"vitro.":[101,127],"demonstrate,":[103],"first":[106],"time,":[107],"long":[109],"term":[110],"an":[113],"cell":[115,181],"culture":[116,182],"with":[117,231],"potent":[119],"inhibitor":[121],"promotes":[122],"sustained":[123],"viral":[124],"clearance":[125],"have":[129],"confirmed":[130],"single":[133],"amino":[134,173,188],"acid":[135,174,189],"variant,":[136],"V719G,":[137],"transmembrane":[140],"domain":[141],"E2":[143],"is":[144],"sufficient":[145],"confer":[147],"resistance":[148],"multiple":[150],"from":[152],"triazine":[154,263,270],"series.":[155],"Resistance":[156],"studies":[157],"were":[158],"extended":[159],"by":[160],"evaluating":[161],"fusogenic":[164],"properties":[165,267],"growth":[167],"kinetics":[168],"drug-induced":[170],"natural":[172,251],"variants":[175],"HCVpp":[178],"assays.":[183],"Our":[184],"results":[185],"indicate":[186],"variations":[190],"at":[191],"position":[192],"719":[193],"incur":[194],"significant":[196,237],"fitness":[197],"penalty.":[198],"Introduction":[199],"I719":[201,234],"into":[202],"genotype":[204,226,243],"1b":[205,244],"envelope":[206],"sequence":[207],"did":[208,253],"not":[209,254],"affect":[210],"entry;":[212],"however,":[213],"overall":[215],"level":[216],"replication":[219],"was":[220],"reduced":[221],"compared":[222],"parental":[225],"1b/2a":[227],"strain.":[229],"Consistent":[230],"these":[232,269],"findings,":[233],"fraction":[238],"naturally":[241],"occurring":[242],"sequences.":[245],"Importantly,":[246],"I719,":[247],"most":[249],"relevant":[250],"polymorphism,":[252],"significantly":[255],"alter":[256],"susceptibility":[258],"compounds.":[264],"The":[265],"preclinical":[266],"support":[272],"further":[273],"investigation":[274],"as":[278],"therapy":[282]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
