{"id":"https://openalex.org/W1976007948","doi":"https://doi.org/10.1016/s0304-3835(99)00121-4","title":"Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis","display_name":"Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W1976007948","doi":"https://doi.org/10.1016/s0304-3835(99)00121-4","mag":"1976007948","pmid":"https://pubmed.ncbi.nlm.nih.gov/10503900"},"language":"en","primary_location":{"id":"doi:10.1016/s0304-3835(99)00121-4","doi":"https://doi.org/10.1016/s0304-3835(99)00121-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3835(99)00121-4","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011183162","display_name":"Meirong Xu","orcid":"https://orcid.org/0000-0001-6573-1179","observed_orcids":["https://orcid.org/0000-0001-6573-1179"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meirong Xu","raw_affiliation_strings":["The Linus Pauling Institute, and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331-6512, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Linus Pauling Institute, and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331-6512, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082820494","display_name":"Roderick H. Dashwood","orcid":"https://orcid.org/0000-0003-0351-4034","observed_orcids":["https://orcid.org/0000-0003-0351-4034"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roderick H. Dashwood","raw_affiliation_strings":["The Linus Pauling Institute, and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Linus Pauling Institute, and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512, USA","institution_ids":["https://openalex.org/I131249849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082820494"],"corresponding_institution_ids":["https://openalex.org/I131249849"],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":null,"fwci":1.8453,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.85650756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"143","issue":"2","first_page":"179","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9100000262260437},{"id":"https://openalex.org/keywords/heterocyclic-amines","display_name":"heterocyclic amines","score":0.9549999833106995},{"id":"https://openalex.org/keywords/colon-carcinogenesis","display_name":"colon carcinogenesis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/phip","display_name":"PhIP","score":0.8149999976158142},{"id":"https://openalex.org/keywords/iq","display_name":"IQ","score":0.9580000042915344},{"id":"https://openalex.org/keywords/aberrant-crypt-foci","display_name":"aberrant crypt foci","score":0.9769999980926514},{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.8560000061988831},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.7860000133514404},{"id":"https://openalex.org/keywords/chlorophyllin","display_name":"chlorophyllin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/indole-3-carbinol","display_name":"indole-3-carbinol","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tea-catechins","display_name":"tea catechins","score":0.9010000228881836},{"id":"https://openalex.org/keywords/conjugated-linoleic-acid","display_name":"conjugated linoleic acid","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cytochrome-p450-inhibition","display_name":"cytochrome P450 inhibition","score":0.9139999747276306},{"id":"https://openalex.org/keywords/phase-ii-enzymes","display_name":"phase II enzymes","score":0.6830000281333923},{"id":"https://openalex.org/keywords/nadph-cytochrome-p450-reductase","display_name":"NADPH-cytochrome P450 reductase","score":0.9430000185966492},{"id":"https://openalex.org/keywords/molecular-complex-formation","display_name":"molecular complex formation","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2777278644","wikidata":"https://www.wikidata.org/wiki/Q2758348","display_name":"Heterocyclic amine","level":3,"score":0.7404818534851074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7331560254096985},{"id":"https://openalex.org/C2779107934","wikidata":"https://www.wikidata.org/wiki/Q4774590","display_name":"Anticarcinogen","level":4,"score":0.6431491374969482},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6391087174415588},{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.4985957145690918},{"id":"https://openalex.org/C2780669762","wikidata":"https://www.wikidata.org/wiki/Q4667164","display_name":"Aberrant crypt foci","level":5,"score":0.4905700087547302},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47283583879470825},{"id":"https://openalex.org/C2776309666","wikidata":"https://www.wikidata.org/wiki/Q408384","display_name":"Quinoline","level":2,"score":0.46850115060806274},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.4509359300136566},{"id":"https://openalex.org/C2781422964","wikidata":"https://www.wikidata.org/wiki/Q12529398","display_name":"Antimutagen","level":4,"score":0.44228360056877136},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.42261356115341187},{"id":"https://openalex.org/C2779043668","wikidata":"https://www.wikidata.org/wiki/Q584276","display_name":"Aromatic amine","level":2,"score":0.4139742851257324},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41057902574539185},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.4101375937461853},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.3381567597389221},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3250538110733032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23242616653442383},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2044779360294342},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.1945461928844452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16684672236442566},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1079215407371521},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002735","descriptor_name":"Chlorophyllides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002735","descriptor_name":"Chlorophyllides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004336","descriptor_name":"Drug Antagonism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0304-3835(99)00121-4","doi":"https://doi.org/10.1016/s0304-3835(99)00121-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3835(99)00121-4","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:10503900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10503900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2087987326","display_name":"Modulation of Colon Carcinogenesis by Chlorophyllin","funder_award_id":"R01CA065525","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G546173785","display_name":null,"funder_award_id":"CA-65525","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1967450542","https://openalex.org/W1967775878","https://openalex.org/W1970347740","https://openalex.org/W1981690818","https://openalex.org/W2005113788","https://openalex.org/W2016893223","https://openalex.org/W2047673253","https://openalex.org/W2051606213","https://openalex.org/W2069724423","https://openalex.org/W2083378088","https://openalex.org/W2084284247","https://openalex.org/W2085422374","https://openalex.org/W2099260856","https://openalex.org/W2101721166","https://openalex.org/W2106611194","https://openalex.org/W2123245217","https://openalex.org/W2152069967","https://openalex.org/W2168871131"],"related_works":["https://openalex.org/W2085422374","https://openalex.org/W2011787656","https://openalex.org/W2038815580","https://openalex.org/W2040704697","https://openalex.org/W1998761065","https://openalex.org/W2055995053","https://openalex.org/W1968297568","https://openalex.org/W2003996796","https://openalex.org/W4291598497","https://openalex.org/W2079183526"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
