{"id":"https://openalex.org/W1976002178","doi":"https://doi.org/10.1111/j.1365-2559.1982.tb02738.x","title":"Lysozyme in human gastric carcinoma: a retrospective immunohistochemical study","display_name":"Lysozyme in human gastric carcinoma: a retrospective immunohistochemical study","publication_year":1982,"publication_date":"1982-07-01","ids":{"openalex":"https://openalex.org/W1976002178","doi":"https://doi.org/10.1111/j.1365-2559.1982.tb02738.x","mag":"1976002178","pmid":"https://pubmed.ncbi.nlm.nih.gov/6749639"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2559.1982.tb02738.x","doi":"https://doi.org/10.1111/j.1365-2559.1982.tb02738.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2559.1982.tb02738.x","pdf_url":null,"source":{"id":"https://openalex.org/S14376486","display_name":"Histopathology","issn_l":"0309-0167","issn":["0309-0167","1365-2559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109208046","display_name":"E Tahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"E. TAHARA","raw_affiliation_strings":["Department of Pathology, Hiroshima University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hiroshima University School of Medicine","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103275712","display_name":"Hisao Ito","orcid":"https://orcid.org/0009-0003-0326-903X","observed_orcids":["https://orcid.org/0009-0003-0326-903X"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. ITO","raw_affiliation_strings":["Department of Pathology, Hiroshima University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hiroshima University School of Medicine","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027785421","display_name":"Fumio Shimamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"F. SHIMAMOTO","raw_affiliation_strings":["Department of Pathology, Hiroshima University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hiroshima University School of Medicine","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034629153","display_name":"Toshiyuki Iwamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. IWAMOTO","raw_affiliation_strings":["Department of Pathology, Hiroshima University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hiroshima University School of Medicine","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034744290","display_name":"Kazuhiko Nakagami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. NAKAGAMI","raw_affiliation_strings":["Department of Pathology, Hiroshima University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hiroshima University School of Medicine","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038049433","display_name":"H. NIIMOTO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. NIIMOTO","raw_affiliation_strings":["Department of Surgery, Research Institute for Nuclear Medicine and Biology, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Research Institute for Nuclear Medicine and Biology, Hiroshima University","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109208046"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":2.5977,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.89470399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"4","first_page":"409","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/early-gastric-cancer","display_name":"early gastric cancer","score":0.7490000128746033},{"id":"https://openalex.org/keywords/advanced-gastric-cancer","display_name":"advanced gastric cancer","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mucin","display_name":"mucin","score":0.7149999737739563},{"id":"https://openalex.org/keywords/argentaffin-cells","display_name":"argentaffin cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/signet-ring-cell-carcinoma","display_name":"signet ring cell carcinoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-cell-differentiation","display_name":"tumor cell differentiation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6029999852180481},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.9647213220596313},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.7050213813781738},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7005478143692017},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6002121567726135},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5313236117362976},{"id":"https://openalex.org/C2993220764","wikidata":"https://www.wikidata.org/wiki/Q189588","display_name":"Gastric carcinoma","level":3,"score":0.5169245600700378},{"id":"https://openalex.org/C2911142149","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colonic Carcinoma","level":3,"score":0.49109816551208496},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48308876156806946},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.465238481760025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4564951956272125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3106305003166199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2615017890930176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06819209456443787},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2559.1982.tb02738.x","doi":"https://doi.org/10.1111/j.1365-2559.1982.tb02738.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2559.1982.tb02738.x","pdf_url":null,"source":{"id":"https://openalex.org/S14376486","display_name":"Histopathology","issn_l":"0309-0167","issn":["0309-0167","1365-2559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"journal-article"},{"id":"pmid:6749639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6749639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1965814874","https://openalex.org/W1973143728","https://openalex.org/W1977802642","https://openalex.org/W1979191897","https://openalex.org/W1988893375","https://openalex.org/W2014209146","https://openalex.org/W2041497034","https://openalex.org/W2049936320","https://openalex.org/W2058046724","https://openalex.org/W2088821093","https://openalex.org/W2090758167","https://openalex.org/W2091014212","https://openalex.org/W2121279588","https://openalex.org/W2137108435","https://openalex.org/W2143400557","https://openalex.org/W2164821085","https://openalex.org/W2410876903","https://openalex.org/W4243390175"],"related_works":["https://openalex.org/W2170130696","https://openalex.org/W2381118540","https://openalex.org/W1979074523","https://openalex.org/W2032016789","https://openalex.org/W2005210563","https://openalex.org/W1979191897","https://openalex.org/W2090572837","https://openalex.org/W2885343790","https://openalex.org/W2019014461","https://openalex.org/W2122358200"],"abstract_inverted_index":{"A":[0],"total":[1],"of":[2,30,38,51,85,88,117],"171":[3,32],"gastric":[4,33,52,143],"carcinomas":[5,67],"comprising":[6],"69":[7],"advanced":[8,142],"cancers":[9,13,144],"and":[10,48,62,80,97,114],"102":[11],"early":[12],"were":[14,23],"examined":[15],"immunohistochemically":[16],"for":[17,141],"lysozyme.":[18],"Tumour":[19],"cells":[20,40,93,113],"containing":[21,94,145],"lysozyme":[22,96,108,125,146],"detected":[24],"in":[25,110],"65":[26,57],"cases":[27],"or":[28,77,119],"38%":[29],"the":[31,55,111,122],"cancer":[34],"cases.":[35],"The":[36,124,133],"incidence":[37],"these":[39],"did":[41],"not":[42],"differ":[43],"remarkably":[44],"by":[45,130],"histological":[46],"type":[47],"infiltrative":[49],"growth":[50],"carcinoma.":[53],"Of":[54],"foregoing":[56],"cases,":[58],"two":[59,134],"well-differentiated":[60],"adenocarcinomas":[61],"three":[63],"signet":[64],"ring":[65],"cell":[66],"had":[68,74,82],"numerous":[69],"lysozyme-containing":[70],"tumour":[71,92,112,131],"cells,":[72,79],"13":[73],"many":[75],"argentaffin":[76],"argyrophil":[78],"40":[81],"various":[83],"amounts":[84],"several":[86],"types":[87],"mucin.":[89],"In":[90],"addition,":[91],"both":[95],"mucin":[98],"could":[99,104],"be":[100,105,128],"identified.":[101],"No":[102],"correlation":[103],"observed":[106],"between":[107],"immunoreactivity":[109],"cellular":[115],"infiltration":[116],"granulocytes":[118],"macrophages":[120],"around":[121],"tumour.":[123],"appeared":[126],"to":[127,147],"produced":[129],"cells.":[132],"year":[135],"survival":[136],"rates":[137],"indicate":[138],"a":[139,149],"tendency":[140],"have":[148],"poor":[150],"prognosis.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
