{"id":"https://openalex.org/W1975998928","doi":"https://doi.org/10.1001/archpsyc.1967.01730230001001","title":"Pituitary Adrenal Function and Depression","display_name":"Pituitary Adrenal Function and Depression","publication_year":1967,"publication_date":"1967-05-01","ids":{"openalex":"https://openalex.org/W1975998928","doi":"https://doi.org/10.1001/archpsyc.1967.01730230001001","mag":"1975998928","pmid":"https://pubmed.ncbi.nlm.nih.gov/5337615"},"language":"en","primary_location":{"id":"doi:10.1001/archpsyc.1967.01730230001001","doi":"https://doi.org/10.1001/archpsyc.1967.01730230001001","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archpsyc.1967.01730230001001","pdf_url":null,"source":{"id":"https://openalex.org/S126359496","display_name":"Archives of General Psychiatry","issn_l":"0003-990X","issn":["0003-990X","1538-3636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of General Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111659801","display_name":"JAN A. FAWCETT","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jan A. Fawcett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111659801"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.0357,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.98809524,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"5","first_page":"517","last_page":"517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pituitary-adrenal-axis","display_name":"pituitary-adrenal axis","score":0.871999979019165},{"id":"https://openalex.org/keywords/17-hydroxycorticosteroids","display_name":"17-hydroxycorticosteroids","score":0.8799999952316284},{"id":"https://openalex.org/keywords/plasma-cortisol","display_name":"plasma cortisol","score":0.4740000069141388},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.6669999957084656},{"id":"https://openalex.org/keywords/general-adaptation-syndrome","display_name":"general adaptation syndrome","score":0.9449999928474426},{"id":"https://openalex.org/keywords/steroid-metabolism","display_name":"steroid metabolism","score":0.8920000195503235},{"id":"https://openalex.org/keywords/psychoneuroendocrinology","display_name":"psychoneuroendocrinology","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7294676303863525},{"id":"https://openalex.org/C3017452174","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal function","level":2,"score":0.6243970990180969},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5936435461044312},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5393459796905518},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49105381965637207},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4358982443809509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4298322796821594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3295750617980957},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2554894983768463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12953051924705505},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archpsyc.1967.01730230001001","doi":"https://doi.org/10.1001/archpsyc.1967.01730230001001","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archpsyc.1967.01730230001001","pdf_url":null,"source":{"id":"https://openalex.org/S126359496","display_name":"Archives of General Psychiatry","issn_l":"0003-990X","issn":["0003-990X","1538-3636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of General Psychiatry","raw_type":"journal-article"},{"id":"pmid:5337615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5337615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of general psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W991319","https://openalex.org/W118003988","https://openalex.org/W177974980","https://openalex.org/W188614741","https://openalex.org/W596401249","https://openalex.org/W1562374320","https://openalex.org/W1604649689","https://openalex.org/W1963777445","https://openalex.org/W1964069789","https://openalex.org/W1971162866","https://openalex.org/W1978785029","https://openalex.org/W1981494247","https://openalex.org/W1982630078","https://openalex.org/W1982660038","https://openalex.org/W1982746127","https://openalex.org/W1988340287","https://openalex.org/W1999520838","https://openalex.org/W2006836052","https://openalex.org/W2012561247","https://openalex.org/W2016728296","https://openalex.org/W2018022290","https://openalex.org/W2019915165","https://openalex.org/W2023565092","https://openalex.org/W2024348244","https://openalex.org/W2024403375","https://openalex.org/W2026475842","https://openalex.org/W2031232949","https://openalex.org/W2031761393","https://openalex.org/W2032078477","https://openalex.org/W2032822876","https://openalex.org/W2040498292","https://openalex.org/W2040724077","https://openalex.org/W2044406485","https://openalex.org/W2045582164","https://openalex.org/W2046575894","https://openalex.org/W2049425824","https://openalex.org/W2057667850","https://openalex.org/W2059871568","https://openalex.org/W2060495357","https://openalex.org/W2060658266","https://openalex.org/W2062733248","https://openalex.org/W2064238441","https://openalex.org/W2065463514","https://openalex.org/W2065862208","https://openalex.org/W2078332746","https://openalex.org/W2078480031","https://openalex.org/W2084839325","https://openalex.org/W2085799988","https://openalex.org/W2086408248","https://openalex.org/W2088054956","https://openalex.org/W2088762521","https://openalex.org/W2090912992","https://openalex.org/W2092030882","https://openalex.org/W2093036934","https://openalex.org/W2094795590","https://openalex.org/W2096010556","https://openalex.org/W2102129880","https://openalex.org/W2108744210","https://openalex.org/W2118231667","https://openalex.org/W2120250070","https://openalex.org/W2123597383","https://openalex.org/W2126321494","https://openalex.org/W2126407832","https://openalex.org/W2129564365","https://openalex.org/W2135242928","https://openalex.org/W2138212707","https://openalex.org/W2146011569","https://openalex.org/W2152787669","https://openalex.org/W2158582141","https://openalex.org/W2159590276","https://openalex.org/W2159772775","https://openalex.org/W2162526960","https://openalex.org/W2165789416","https://openalex.org/W2218162643","https://openalex.org/W2292709442","https://openalex.org/W2295048407","https://openalex.org/W2309845681","https://openalex.org/W2312353356","https://openalex.org/W2313277819","https://openalex.org/W2319841297","https://openalex.org/W2320738289","https://openalex.org/W2320740027","https://openalex.org/W2325671998","https://openalex.org/W2328566737","https://openalex.org/W2335103045","https://openalex.org/W2341149966","https://openalex.org/W2341194388","https://openalex.org/W2341786823","https://openalex.org/W2344198924","https://openalex.org/W2397447557","https://openalex.org/W2398294218","https://openalex.org/W2401305255","https://openalex.org/W2401713156","https://openalex.org/W2408894819","https://openalex.org/W2410219444","https://openalex.org/W2410802411","https://openalex.org/W2413303295","https://openalex.org/W2415223279","https://openalex.org/W2416145602","https://openalex.org/W2416941416","https://openalex.org/W2418963363","https://openalex.org/W2500980413","https://openalex.org/W2997790741","https://openalex.org/W4234386942"],"related_works":["https://openalex.org/W2412125714","https://openalex.org/W2126321494","https://openalex.org/W2013048907","https://openalex.org/W2100152338","https://openalex.org/W1980232096","https://openalex.org/W2042169494","https://openalex.org/W1605125357","https://openalex.org/W2138632275","https://openalex.org/W2461197415","https://openalex.org/W2123597383"],"abstract_inverted_index":{"OVER":[0],"the":[1,7,10,78,119],"past":[2],"two":[3],"decades,":[4],"since":[5],"Selye1introduced":[6],"concept":[8],"of":[9,17,53,75,77,80,118,121],"\"general":[11],"adaptation":[12],"syndrome,\"":[13],"an":[14,108],"impressive":[15],"body":[16],"psychoendocrine":[18],"studies":[19],"has":[20],"described":[21],"increased":[22],"17-hydroxycorticosteroid":[23],"(17-OHCS)":[24],"excretion":[25],"and":[26,40,47,86,102,106],"elevated":[27],"plasma":[28],"17-OHCS":[29],"levels":[30],"in":[31,51,61,84,88,92,113],"association":[32],"with":[33],"psychological":[34],"responses":[35],"to":[36,70,124],"both":[37],"naturally":[38],"occurring":[39],"experimentally":[41],"contrived":[42],"stress":[43],"situations.":[44],"Relatively":[45],"greater":[46],"more":[48],"sustained":[49],"increases":[50],"indices":[52],"pituitary":[54,81,103],"adrenal":[55,82,104],"function":[56,83,105],"have":[57],"been":[58],"well":[59],"documented":[60],"some":[62],"severely":[63],"depressed":[64],"patients.":[65],"The":[66],"potential":[67],"now":[68],"exists":[69],"pursue":[71],"a":[72,89,135],"new":[73],"level":[74],"investigation":[76],"role":[79],"depression,":[85],"perhaps":[87],"broader":[90],"sense,":[91],"human":[93],"behavior.":[94],"This":[95],"paper":[96],"reviews":[97],"current":[98],"data":[99],"relating":[100],"depression":[101,125],"proposes":[107],"outline":[109],"for":[110],"future":[111],"research":[112],"this":[114],"field.":[115],"A":[116],"consideration":[117],"relationship":[120],"steroid":[122],"metabolism":[123],"suggests":[126],"three":[127],"overall":[128],"questions.":[129],"(1)":[130],"Is":[131],"there":[132],"evidence":[133],"that":[134],"consistent":[136],"significant":[137],"alteration":[138]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
