{"id":"https://openalex.org/W1975911554","doi":"https://doi.org/10.1159/000110024","title":"Associations between Notch-2, Akt-1 and HER2/neu Expression in Invasive Human Breast Cancer: A Tissue Microarray Immunophenotypic Analysis on 98 Patients","display_name":"Associations between Notch-2, Akt-1 and HER2/neu Expression in Invasive Human Breast Cancer: A Tissue Microarray Immunophenotypic Analysis on 98 Patients","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1975911554","doi":"https://doi.org/10.1159/000110024","mag":"1975911554","pmid":"https://pubmed.ncbi.nlm.nih.gov/18087195"},"language":"en","primary_location":{"id":"doi:10.1159/000110024","doi":"https://doi.org/10.1159/000110024","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000110024","pdf_url":null,"source":{"id":"https://openalex.org/S18964055","display_name":"Pathobiology","issn_l":"1015-2008","issn":["1015-2008","1423-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10447/21500","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047903927","display_name":"Ada Maria Florena","orcid":"https://orcid.org/0000-0002-5450-0890","observed_orcids":["https://orcid.org/0000-0002-5450-0890"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ada Maria Florena","raw_affiliation_strings":["Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088581133","display_name":"Claudio Tripodo","orcid":"https://orcid.org/0000-0002-0821-6231","observed_orcids":["https://orcid.org/0000-0002-0821-6231"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Tripodo","raw_affiliation_strings":["Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079721906","display_name":"Carla Guarnotta","orcid":"https://orcid.org/0000-0002-5118-8563","observed_orcids":["https://orcid.org/0000-0002-5118-8563"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla Guarnotta","raw_affiliation_strings":["Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080744563","display_name":"Sabrina Ingrao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabrina Ingrao","raw_affiliation_strings":["Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016417850","display_name":"Rossana Porcasi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossana Porcasi","raw_affiliation_strings":["Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","Biomedico di Medicina Interna e Specialistica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Biomedico di Medicina Interna e Specialistica","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051515926","display_name":"Annamaria Martorana","orcid":"https://orcid.org/0000-0002-9560-1882","observed_orcids":["https://orcid.org/0000-0002-9560-1882"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Martorana","raw_affiliation_strings":["Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089392019","display_name":"Giosu\u00e8 Lo Bosco","orcid":"https://orcid.org/0000-0002-1602-0693","observed_orcids":["https://orcid.org/0000-0002-1602-0693"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giosu\u00e8 Lo Bosco","raw_affiliation_strings":["Matematica e Informatica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matematica e Informatica","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010187100","display_name":"Daniela Cabibi","orcid":"https://orcid.org/0000-0001-6571-6577","observed_orcids":["https://orcid.org/0000-0001-6571-6577"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Cabibi","raw_affiliation_strings":["Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090620646","display_name":"Vito Franco","orcid":"https://orcid.org/0000-0003-3231-1367","observed_orcids":["https://orcid.org/0000-0003-3231-1367"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vito Franco","raw_affiliation_strings":["Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Patologia Umana, Universit\u00e0 degli Studi di Palermo, Palermo, Italia","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Scienze per la Promozione della Salute e Materno Infantile G.D'Alessandro","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9248,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.74359948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"74","issue":"6","first_page":"317","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch2","display_name":"Notch2","score":0.843999981880188},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.996999979019165},{"id":"https://openalex.org/keywords/invasive-breast-cancer","display_name":"invasive breast cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7559999823570251},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6916765570640564},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.680044412612915},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.664726734161377},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5603048205375671},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5247079133987427},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48013660311698914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45817893743515015},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.45251229405403137},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4523032009601593},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.44244828820228577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43474578857421875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42898404598236084},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4200358986854553},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.4153357744216919},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38393133878707886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34366047382354736},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33197128772735596},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.11167904734611511},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051883","descriptor_name":"Receptor, Notch2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1159/000110024","doi":"https://doi.org/10.1159/000110024","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000110024","pdf_url":null,"source":{"id":"https://openalex.org/S18964055","display_name":"Pathobiology","issn_l":"1015-2008","issn":["1015-2008","1423-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology","raw_type":"journal-article"},{"id":"pmid:18087195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18087195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology : journal of immunopathology, molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unipa.it:10447/21500","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10447/21500","pdf_url":"http://hdl.handle.net/10447/21500","source":{"id":"https://openalex.org/S4377196289","display_name":"IRIS UniPA (University of Palermo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I900890020","host_organization_name":"University of Palermo","host_organization_lineage":["https://openalex.org/I900890020"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:iris.unipa.it:10447/21500","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10447/21500","pdf_url":"http://hdl.handle.net/10447/21500","source":{"id":"https://openalex.org/S4377196289","display_name":"IRIS UniPA (University of Palermo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I900890020","host_organization_name":"University of Palermo","host_organization_lineage":["https://openalex.org/I900890020"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975911554.pdf","grobid_xml":"https://content.openalex.org/works/W1975911554.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W116062262","https://openalex.org/W1509578301","https://openalex.org/W1515648506","https://openalex.org/W1827067753","https://openalex.org/W1833778497","https://openalex.org/W1964572508","https://openalex.org/W2000969116","https://openalex.org/W2001366190","https://openalex.org/W2007921174","https://openalex.org/W2009218955","https://openalex.org/W2010687252","https://openalex.org/W2010871781","https://openalex.org/W2033185779","https://openalex.org/W2046734019","https://openalex.org/W2057155919","https://openalex.org/W2057600556","https://openalex.org/W2071196711","https://openalex.org/W2078159546","https://openalex.org/W2087810003","https://openalex.org/W2100799873","https://openalex.org/W2118202495","https://openalex.org/W2123129045","https://openalex.org/W2142105072","https://openalex.org/W2159302075","https://openalex.org/W2168203442","https://openalex.org/W2231156824","https://openalex.org/W3198835821"],"related_works":["https://openalex.org/W2099445963","https://openalex.org/W2598686364","https://openalex.org/W2352744839","https://openalex.org/W2159302075","https://openalex.org/W3110093646","https://openalex.org/W2159950734","https://openalex.org/W1816419236","https://openalex.org/W2062711358","https://openalex.org/W2393343308","https://openalex.org/W2382633200"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1],"aimed":[2],"to":[3],"investigate":[4],"the":[5,37,51,75,88,146,169,179],"existence":[6,147],"of":[7,18,30,40,90,148,151,160,171,181],"associations":[8,80,94,120],"between":[9,81,97,123],"well-established":[10],"and":[11,15,25,42,48,63,72,99,104,109,112,115,117,126,131,134,137,139,162,183,189],"newly":[12],"recognized":[13],"biological":[14],"phenotypic":[16],"features":[17,85],"breast":[19,32,186],"cancer":[20,33,187],"involved":[21],"in":[22,74,185],"tumor":[23,57,61,102,107,127,135],"progression":[24,188],"prognosis.":[26],"METHODS:":[27],"Ninety-eight":[28],"cases":[29],"invasive":[31],"were":[34,67,95,121],"assessed":[35],"for":[36,69],"immunohistochemical":[38],"expression":[39],"estrogen":[41,98,113,152],"progesterone":[43,100],"receptors,":[44,101,114],"Ki-67,":[45],"HER2,":[46,110,132],"Akt-1,":[47],"Notch-2,":[49],"using":[50],"tissue":[52],"microarray":[53],"technique.":[54],"Data":[55],"regarding":[56],"histotype,":[58],"histological":[59,82],"grade,":[60,128,136],"size":[62],"lymph":[64,164],"node":[65,165],"status":[66],"collected":[68],"each":[70],"patient":[71],"included":[73],"analysis.":[76],"RESULTS:":[77],"Several":[78],"significant":[79],"and/or":[83],"immunophenotypic":[84],"came":[86],"from":[87],"analysis":[89],"our":[91],"data.":[92],"Positive":[93],"observed":[96],"grade":[103,108],"proliferation":[105],"index,":[106],"Akt-1":[111,133,138,156],"Notch-2":[116,176],"HER2.":[118],"Inverse":[119],"noted":[122],"hormone":[124,129],"receptors":[125,130],"nodal":[140],"invasion.":[141],"CONCLUSIONS:":[142],"Our":[143],"results,":[144],"showing":[145],"a":[149],"number":[150],"receptor-positive":[153],"tumors":[154,173],"with":[155,168,174],"expression,":[157,177],"better":[158],"degree":[159],"differentiation,":[161],"no":[163],"involvement,":[166],"along":[167],"presence":[170],"HER2-positive":[172],"strong":[175],"support":[178],"role":[180],"Notch":[182],"Akt":[184],"suggest":[190],"that":[191],"they":[192],"may":[193],"also":[194],"represent":[195],"new":[196],"appealing":[197],"therapeutic":[198],"targets.":[199]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}