{"id":"https://openalex.org/W1975901451","doi":"https://doi.org/10.1089/hum.2005.16.1110","title":"Efficient Delivery of RNA Interference Effectors via In Vitro-Packaged SV40 Pseudovirions","display_name":"Efficient Delivery of RNA Interference Effectors via In Vitro-Packaged SV40 Pseudovirions","publication_year":2005,"publication_date":"2005-08-22","ids":{"openalex":"https://openalex.org/W1975901451","doi":"https://doi.org/10.1089/hum.2005.16.1110","mag":"1975901451","pmid":"https://pubmed.ncbi.nlm.nih.gov/16149909","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1618762"},"language":"en","primary_location":{"id":"doi:10.1089/hum.2005.16.1110","doi":"https://doi.org/10.1089/hum.2005.16.1110","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2005.16.1110","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035292060","display_name":"Chava Kimchi\u2010Sarfaty","orcid":"https://orcid.org/0000-0002-9355-8585","observed_orcids":["https://orcid.org/0000-0002-9355-8585"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chava Kimchi-Sarfaty","raw_affiliation_strings":["Current address: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892","Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060639680","display_name":"Scott M. Brittain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Brittain","raw_affiliation_strings":["Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048501263","display_name":"Susan H. Garfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Garfield","raw_affiliation_strings":["Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052362487","display_name":"Natasha J. Caplen","orcid":"https://orcid.org/0000-0002-0001-9460","observed_orcids":["https://orcid.org/0000-0002-0001-9460"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha J. Caplen","raw_affiliation_strings":["Gene Silencing Section, Office of Science and Technology Partnerships, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Silencing Section, Office of Science and Technology Partnerships, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110390767","display_name":"Qingquan Tang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingquan Tang","raw_affiliation_strings":["Genomics and Drug Discovery, Intradigm, Rockville, MD 20852"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Drug Discovery, Intradigm, Rockville, MD 20852","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030334751","display_name":"Michael M. Gottesman","orcid":"https://orcid.org/0000-0001-8908-2097","observed_orcids":["https://orcid.org/0000-0001-8908-2097"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Gottesman","raw_affiliation_strings":["Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1661,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.73809575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"0","issue":"0","first_page":"050822135735001","last_page":"050822135735001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.9459999799728394},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.7770000100135803},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7440000176429749},{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.7549999952316284},{"id":"https://openalex.org/keywords/lymphoblastoid-cell-lines","display_name":"lymphoblastoid cell lines","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.8098798990249634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.708234429359436},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.6649768352508545},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.6181435585021973},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5993227958679199},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5576552152633667},{"id":"https://openalex.org/C60723119","wikidata":"https://www.wikidata.org/wiki/Q7833577","display_name":"Trans-acting siRNA","level":5,"score":0.5499878525733948},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.5413988828659058},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5397845506668091},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5236494541168213},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5010426044464111},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.49168092012405396},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4772493839263916},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.4606930911540985},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3658342957496643},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27250412106513977},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19166594743728638},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.08928140997886658}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/hum.2005.16.1110","doi":"https://doi.org/10.1089/hum.2005.16.1110","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2005.16.1110","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"doi:10.1089/hum.2005.16.ft-110","doi":"https://doi.org/10.1089/hum.2005.16.ft-110","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2005.16.ft-110","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:16149909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16149909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310702","display_name":"National Cancer Research Institute","ror":"https://ror.org/02mp0vf47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1973641650","https://openalex.org/W1998513236","https://openalex.org/W2019387053","https://openalex.org/W2019411198","https://openalex.org/W2030276103","https://openalex.org/W2070564266","https://openalex.org/W2071113161","https://openalex.org/W2074641061","https://openalex.org/W2091238654","https://openalex.org/W2110310164","https://openalex.org/W2130083086","https://openalex.org/W2136447541","https://openalex.org/W2154861374","https://openalex.org/W2176875138","https://openalex.org/W2300839802","https://openalex.org/W4233808990"],"related_works":["https://openalex.org/W2328168694","https://openalex.org/W2300839802","https://openalex.org/W2162563824","https://openalex.org/W7098771099","https://openalex.org/W2030276103","https://openalex.org/W2176875138","https://openalex.org/W4246604545","https://openalex.org/W2074641061","https://openalex.org/W2039099279","https://openalex.org/W2051634046"],"abstract_inverted_index":{"Previously":[0],"we":[1],"have":[2],"shown":[3],"that":[4,170],"in":[5,140,157],"vitro-packaged":[6],"simian":[7],"virus":[8],"40":[9],"(SV40)":[10],"pseudovirions":[11,59,172],"(IVPs)":[12],"are":[13],"an":[14,109],"efficient":[15],"delivery":[16,180],"system":[17],"for":[18,185],"supercoiled":[19],"DNA":[20,101,118],"plasmids":[21],"of":[22,57,68,85,95,120,129,147,188],"up":[23],"to":[24,60,89,112,123,153,178],"17.7":[25],"kb,":[26],"with":[27,98,165],"or":[28],"without":[29],"SV40":[30,58,116,134,171],"sequences.":[31],"RNA":[32,45],"interference":[33],"(RNAi)":[34],"is":[35],"a":[36,162,175],"naturally":[37],"occurring":[38],"gene-silencing":[39],"mechanism":[40],"mediated":[41],"by":[42],"small":[43],"double-stranded":[44],"molecules":[46],"(small":[47],"interfering":[48],"RNAs,":[49],"siRNAs).":[50],"This":[51],"study":[52],"demonstrates":[53],"the":[54,83,103,113,124,179,186],"first":[55,81],"use":[56],"deliver":[61],"into":[62],"human":[63,86],"cells":[64,88,97,159],"both":[65,141],"principal":[66],"types":[67],"RNAi":[69,137,189],"effector":[70,190],"molecules:":[71],"plasmid-expressed":[72],"short":[73],"hairpin":[74],"RNAs":[75],"(shRNAs)":[76],"and":[77,108,149,156],"synthetic":[78],"siRNAs.":[79],"We":[80],"established":[82],"ability":[84],"lymphoblastoid":[87],"support":[90],"RNAi,":[91],"using":[92],"sequential":[93,145],"transduction":[94,146],".45":[96,142],"packaged":[99],"plasmid":[100],"expressing":[102,161],"green":[104],"fluorescent":[105],"protein":[106],"(IVP-GFP),":[107],"shRNA":[110],"corresponding":[111,152],"GFP":[114,154,163],"(IVP-shGFP).":[115],"mediates":[117],"transfer":[119,187],"nucleic":[121],"acid":[122],"cytoplasm,":[125],"where":[126],"RNAi-associated":[127],"cleavage":[128],"mRNA":[130],"principally":[131],"occurs.":[132],"Using":[133],"pseudovirions,":[135],"siRNA-mediated":[136],"was":[138],"observed":[139],"cells,":[143],"after":[144],"IVP-GFP":[148],"IVP-packaged":[150],"siRNAs":[151],"(IVP-siGFP),":[155],"HeLa":[158],"stably":[160],"transduced":[164],"IVP-siGFP.":[166],"Our":[167],"findings":[168],"indicate":[169],"may":[173],"be":[174],"useful":[176],"addition":[177],"systems":[181],"currently":[182],"being":[183],"used":[184],"molecules.":[191]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}