{"id":"https://openalex.org/W1975883602","doi":"https://doi.org/10.1016/0300-483x(94)90210-0","title":"In vivo and in vitro 4-amino-2,6-dichlorophenol nephrotoxicity and hepatotoxicity in the Fischer 344 rat","display_name":"In vivo and in vitro 4-amino-2,6-dichlorophenol nephrotoxicity and hepatotoxicity in the Fischer 344 rat","publication_year":1994,"publication_date":"1994-05-01","ids":{"openalex":"https://openalex.org/W1975883602","doi":"https://doi.org/10.1016/0300-483x(94)90210-0","mag":"1975883602","pmid":"https://pubmed.ncbi.nlm.nih.gov/8023337"},"language":"en","primary_location":{"id":"doi:10.1016/0300-483x(94)90210-0","doi":"https://doi.org/10.1016/0300-483x(94)90210-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0300-483x(94)90210-0","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026517567","display_name":"Gary O'Neal Rankin","orcid":"https://orcid.org/0000-0002-5385-3512","observed_orcids":["https://orcid.org/0000-0002-5385-3512"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary O. Rankin","raw_affiliation_strings":["Department of Pharmacology, Marshall University School of Medicine, Huntington, West Virginia 25755-9310"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Marshall University School of Medicine, Huntington, West Virginia 25755-9310","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018878943","display_name":"Monica A. Valentovic","orcid":"https://orcid.org/0000-0001-7065-5721","observed_orcids":["https://orcid.org/0000-0001-7065-5721"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica A. Valentovic","raw_affiliation_strings":["Department of Pharmacology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Derek W. Nicoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek W. Nicoll","raw_affiliation_strings":["Department of Pharmacology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088635150","display_name":"John G. Ball","orcid":"https://orcid.org/0000-0002-1874-8135","observed_orcids":["https://orcid.org/0000-0002-1874-8135"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G. Ball","raw_affiliation_strings":["Department of Pharmacology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108222937","display_name":"D Patrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dianne K. Patrick","raw_affiliation_strings":["Department of Pharmacology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA","Department of Anatomy, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA","institution_ids":["https://openalex.org/I88694374"]},{"raw_affiliation_string":"Department of Anatomy, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ruu-Tong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruu-Tong Wang","raw_affiliation_strings":["Department of Anatomy, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"last","author":{"id":null,"display_name":"Patrick I. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick I. Brown","raw_affiliation_strings":["Department of Anatomy, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, West Virginia 25755-9310, USA","institution_ids":["https://openalex.org/I88694374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026517567"],"corresponding_institution_ids":["https://openalex.org/I88694374"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":2.5318,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.88167179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"90","issue":"1-2","first_page":"115","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.36890000104904175,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.36890000104904175,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.16760000586509705,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.1046999990940094,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":1.0},{"id":"https://openalex.org/keywords/halogenated-anilines","display_name":"halogenated anilines","score":0.9269999861717224},{"id":"https://openalex.org/keywords/aminophenols","display_name":"aminophenols","score":0.9179999828338623},{"id":"https://openalex.org/keywords/proximal-tubular-necrosis","display_name":"proximal tubular necrosis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/organic-anion-transport","display_name":"organic anion transport","score":0.5490000247955322},{"id":"https://openalex.org/keywords/organic-cation-transport","display_name":"organic cation transport","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gluconeogenesis-inhibition","display_name":"gluconeogenesis inhibition","score":0.8410000205039978},{"id":"https://openalex.org/keywords/lactate-dehydrogenase-leakage","display_name":"lactate dehydrogenase leakage","score":0.9700000286102295},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.33899998664855957},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.7905362844467163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7176244854927063},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6478108167648315},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5551723837852478},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4935849905014038},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.49279335141181946},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.47100913524627686},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.45589426159858704},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45290476083755493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4477357268333435},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44760459661483765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3860667943954468},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19080880284309387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09936916828155518},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09348765015602112},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002733","descriptor_name":"Chlorophenols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002733","descriptor_name":"Chlorophenols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006029","descriptor_name":"Glycosuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006417","descriptor_name":"Hematuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010130","descriptor_name":"p-Aminohippuric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0300-483x(94)90210-0","doi":"https://doi.org/10.1016/0300-483x(94)90210-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0300-483x(94)90210-0","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:8023337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8023337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2520494722","display_name":"CHLOROANILINE-INDUCED NEPHROTOXICITY","funder_award_id":"R01ES004954","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1539302162","https://openalex.org/W1985893449","https://openalex.org/W1994475612","https://openalex.org/W2000966474","https://openalex.org/W2005078116","https://openalex.org/W2005749652","https://openalex.org/W2021416529","https://openalex.org/W2029388702","https://openalex.org/W2036069049","https://openalex.org/W2050184825","https://openalex.org/W2053919514","https://openalex.org/W2071299439","https://openalex.org/W2072349571","https://openalex.org/W2073289887","https://openalex.org/W2092249878","https://openalex.org/W2103915468","https://openalex.org/W2136544738","https://openalex.org/W2143542298","https://openalex.org/W2156407607","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2095498024","https://openalex.org/W2029893347","https://openalex.org/W3173616949","https://openalex.org/W2053919514","https://openalex.org/W2018316845","https://openalex.org/W2074036268","https://openalex.org/W2032631241","https://openalex.org/W2006248594","https://openalex.org/W1985893449","https://openalex.org/W4252411182"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}