{"id":"https://openalex.org/W1975829347","doi":"https://doi.org/10.1097/00006123-198501000-00005","title":"Treatment of Acute Focal Cerebral Ischemia and Recirculation with d-Propranolol","display_name":"Treatment of Acute Focal Cerebral Ischemia and Recirculation with d-Propranolol","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W1975829347","doi":"https://doi.org/10.1097/00006123-198501000-00005","mag":"1975829347","pmid":"https://pubmed.ncbi.nlm.nih.gov/3974810"},"language":"en","primary_location":{"id":"doi:10.1097/00006123-198501000-00005","doi":"https://doi.org/10.1097/00006123-198501000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-198501000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080069743","display_name":"John P. Latchaw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John P. Latchaw","raw_affiliation_strings":["Departments of Neurosurgery Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery Cleveland, Ohio","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091328673","display_name":"John R. Little","orcid":"https://orcid.org/0000-0003-2034-2684","observed_orcids":["https://orcid.org/0000-0003-2034-2684"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John R. Little","raw_affiliation_strings":["Departments of Neurosurgery Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery Cleveland, Ohio","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056598687","display_name":"Robert M. Slugg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M. Slugg","raw_affiliation_strings":["Departments of Neurosurgery Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery Cleveland, Ohio","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091678274","display_name":"Ronald Peter Lesser","orcid":"https://orcid.org/0000-0003-2232-7410","observed_orcids":["https://orcid.org/0000-0003-2232-7410"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald P. Lesser","raw_affiliation_strings":["Neurology, Cleveland Clinic Foundation. Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Cleveland Clinic Foundation. Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":null,"display_name":"Nicholas Stowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Stowe","raw_affiliation_strings":["Urology, Cleveland Clinic Foundation, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology, Cleveland Clinic Foundation, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091328673"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.964,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.85001023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"1","first_page":"1","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-propranolol","display_name":"D-propranolol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/beta-adrenergic-blockade","display_name":"beta-adrenergic blockade","score":0.8519999980926514},{"id":"https://openalex.org/keywords/focal-cerebral-ischemia","display_name":"focal cerebral ischemia","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cerebral-reperfusion","display_name":"cerebral reperfusion","score":0.7749999761581421},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.6480000019073486},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.746999979019165},{"id":"https://openalex.org/keywords/cerebral-embolism","display_name":"cerebral embolism","score":0.7409999966621399},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7900000214576721},{"id":"https://openalex.org/keywords/eeg-changes","display_name":"EEG changes","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9034031629562378},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.8978410363197327},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7426280975341797},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.610821008682251},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5797831416130066},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.5719867944717407},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.5624128580093384},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.5237584114074707},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5220584869384766},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.44699254631996155},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4146523177623749},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30154722929000854}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/00006123-198501000-00005","doi":"https://doi.org/10.1097/00006123-198501000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-198501000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"doi:10.1227/00006123-198501000-00005","doi":"https://doi.org/10.1227/00006123-198501000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1227/00006123-198501000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:3974810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3974810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2158325139","https://openalex.org/W2054707991","https://openalex.org/W195923487","https://openalex.org/W2085098755","https://openalex.org/W4242139652","https://openalex.org/W3149224426","https://openalex.org/W7095632983","https://openalex.org/W2006496556","https://openalex.org/W153236634","https://openalex.org/W7100209912"],"abstract_inverted_index":{"The":[0,72,223],"purpose":[1],"of":[2,10,20,43,53,68,84,132,176,184,191,225,238],"the":[3,8,64,78,124,129,144,153,162,180,192,226,241],"investigation":[4],"was":[5,74,112,120,148,173,196,210],"to":[6,27,229],"evaluate":[7],"effects":[9],"d-propranolol":[11,73,133,245],"upon":[12,252],"temporary":[13],"cerebral":[14,29,46,138,257],"ischemia":[15],"followed":[16],"by":[17,143],"a":[18,24,89,231,249],"period":[19],"reperfusion,":[21],"that":[22,244],"is,":[23],"situation":[25],"analogous":[26],"major":[28],"artery":[30,47,81],"embolization.":[31],"Twenty":[32],"adult":[33],"cats,":[34],"lightly":[35],"anesthesized":[36],"with":[37],"nitrous":[38],"oxide,":[39],"underwent":[40],"4":[41],"hours":[42,52,102],"right":[44,79,155,164,194],"middle":[45],"(MCA)":[48],"occlusion":[49],"and":[50,59,95,134,201,216],"2":[51,85],"recirculation.":[54],"Ten":[55],"cats":[56,61,186],"were":[57,166,220],"untreated":[58,185],"10":[60],"received":[62],"d-propranolol,":[63],"weak":[65],"beta-blocking":[66],"isomer":[67],"racemic":[69],"(d,l)":[70],"propranolol.":[71],"infused":[75],"directly":[76],"into":[77],"carotid":[80],"at":[82],"doses":[83],"mg/kg,":[86],"given":[87,98],"as":[88],"bolus":[90,130],"immediately":[91,104,127],"before":[92],"MCA":[93,106,135,188],"occlusion,":[94],"0.33":[96],"mg/kg/hour,":[97],"continuously":[99],"for":[100],"6":[101],"beginning":[103],"after":[105,128,187],"occlusion.":[107,136],"Systemic":[108],"arterial":[109],"blood":[110,139],"pressure":[111],"similar":[113,167,197],"in":[114,123,152,161,168,179,198,205,254],"both":[115,169,199],"groups,":[116,170],"but":[117,171],"heart":[118],"rate":[119],"transiently":[121],"reduced":[122],"treated":[125],"group":[126],"injection":[131],"Regional":[137],"flow":[140],"(rCBF),":[141],"measured":[142],"xenon-133":[145],"clearance":[146],"technique,":[147],"not":[149,247],"significantly":[150],"different":[151],"ischemic,":[154,163,193],"hemisphere.":[156],"Electroencephalographic":[157],"(EEG)":[158],"activity":[159,178],"changes":[160,219],"hemisphere":[165,183],"there":[172,209],"significant":[174],"deterioration":[175],"EEG":[177],"left,":[181],"nonischemic":[182],"reopening.":[189],"Swelling":[190],"hemispheres":[195],"groups":[200],"more":[202],"severe":[203],"than":[204],"previous":[206],"studies":[207],"wherein":[208],"no":[211],"recirculation":[212],"phase.":[213],"Carbon":[214],"perfusion":[215],"blood-brain":[217],"barrier":[218],"also":[221],"similar.":[222],"results":[224],"study":[227,242],"failed":[228],"show":[230],"protective":[232],"effect":[233,251],"despite":[234],"theoretical":[235],"beneficial":[236],"actions":[237],"d-propranolol.":[239],"Also,":[240],"demonstrated":[243],"does":[246],"have":[248],"detrimental":[250],"rCBF":[253],"acute":[255],"focal":[256],"ischemia.":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}