{"id":"https://openalex.org/W1975809665","doi":"https://doi.org/10.1111/j.1532-5415.1977.tb00840.x","title":"Cyclandelate in the Treatment of Senile Mental Changes: A Double\u2010Blind Evaluation","display_name":"Cyclandelate in the Treatment of Senile Mental Changes: A Double\u2010Blind Evaluation","publication_year":1977,"publication_date":"1977-12-01","ids":{"openalex":"https://openalex.org/W1975809665","doi":"https://doi.org/10.1111/j.1532-5415.1977.tb00840.x","mag":"1975809665","pmid":"https://pubmed.ncbi.nlm.nih.gov/336670"},"language":"en","primary_location":{"id":"doi:10.1111/j.1532-5415.1977.tb00840.x","doi":"https://doi.org/10.1111/j.1532-5415.1977.tb00840.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1532-5415.1977.tb00840.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051216372","display_name":"DODDA B. RAO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"D. B. Rao","raw_affiliation_strings":["The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Hospital  Oak Forest Illinois","Oak Forest Hospital The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Hospital  Oak Forest Illinois","institution_ids":[]},{"raw_affiliation_string":"Oak Forest Hospital The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Illinois","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068871449","display_name":"E Georgiev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. L. Georgiev","raw_affiliation_strings":["The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Hospital  Oak Forest Illinois","Oak Forest Hospital The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Hospital  Oak Forest Illinois","institution_ids":[]},{"raw_affiliation_string":"Oak Forest Hospital The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Illinois","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. D. Paul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. D. Paul","raw_affiliation_strings":["The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Hospital  Oak Forest Illinois","Oak Forest Hospital The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Hospital  Oak Forest Illinois","institution_ids":[]},{"raw_affiliation_string":"Oak Forest Hospital The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Illinois","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"A. B. Guzman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. B. Guzman","raw_affiliation_strings":["The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Hospital  Oak Forest Illinois","Oak Forest Hospital The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Hospital  Oak Forest Illinois","institution_ids":[]},{"raw_affiliation_string":"Oak Forest Hospital The Department of Medicine in Geriatrics and Chronic Diseases Oak Forest Illinois","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051216372"],"corresponding_institution_ids":[],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":0.6619,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.69471333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"25","issue":"12","first_page":"548","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.2542000114917755,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.18469999730587006,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclandelate","display_name":"cyclandelate","score":1.0},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.4320000112056732},{"id":"https://openalex.org/keywords/cerebral-vasodilators","display_name":"cerebral vasodilators","score":0.925000011920929},{"id":"https://openalex.org/keywords/cerebrovascular-insufficiency","display_name":"cerebrovascular insufficiency","score":0.9670000076293945},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9309999942779541},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.824999988079071},{"id":"https://openalex.org/keywords/symptom-clusters","display_name":"symptom clusters","score":0.6759999990463257},{"id":"https://openalex.org/keywords/nosie","display_name":"NOSIE","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9350461959838867},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7520399689674377},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5453670620918274},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44728463888168335},{"id":"https://openalex.org/C2776890885","wikidata":"https://www.wikidata.org/wiki/Q1067560","display_name":"Vital signs","level":2,"score":0.4438711404800415},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.43469423055648804},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38472792506217957},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3352911174297333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23808246850967407},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.22275397181510925},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1313028335571289},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003495","descriptor_name":"Cyclandelate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008333","descriptor_name":"Mandelic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011581","descriptor_name":"Psychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1532-5415.1977.tb00840.x","doi":"https://doi.org/10.1111/j.1532-5415.1977.tb00840.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1532-5415.1977.tb00840.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},{"id":"pmid:336670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/336670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W51725516","https://openalex.org/W1983244882","https://openalex.org/W1994131284","https://openalex.org/W2010019255","https://openalex.org/W2013951467","https://openalex.org/W2064851098","https://openalex.org/W2069863209","https://openalex.org/W2071281966","https://openalex.org/W2099068053","https://openalex.org/W2164492784","https://openalex.org/W2460958007","https://openalex.org/W2461373008","https://openalex.org/W4251799572"],"related_works":["https://openalex.org/W2087558247","https://openalex.org/W2086315373","https://openalex.org/W2114591918","https://openalex.org/W2064851098","https://openalex.org/W2071281966","https://openalex.org/W1969848259","https://openalex.org/W2406655889","https://openalex.org/W2031945969","https://openalex.org/W2029216131","https://openalex.org/W2417627040"],"abstract_inverted_index":{"The":[0,65,159],"treatment":[1],"of":[2,13,17,33,35,45,55,79,90,114,161,179,210],"cerebrovascular":[3],"insufficiency":[4],"and":[5,67,71,97,111,124,164,172],"its":[6],"many":[7],"symptoms":[8,178],"in":[9,23,42,61,81,108,147,181],"the":[10,14,31,53,94,119,125,149,186,207],"ever-increasing":[11],"numbers":[12],"aged,":[15],"is":[16,39,169,188],"major":[18],"concern":[19],"to":[20,30,51,138,154],"physicians":[21],"engaged":[22],"such":[24],"care.":[25],"Despite":[26],"past":[27],"skepticism":[28],"as":[29],"degree":[32],"efficacy":[34],"cerebral":[36],"vasodilators,":[37],"there":[38],"renewed":[40],"interest":[41],"this":[43,211],"form":[44],"therapy.":[46],"Our":[47],"investigation":[48],"was":[49,145],"designed":[50],"assess":[52],"effectiveness":[54],"cyclandelate,":[56],"under":[57],"strict":[58],"double-blind":[59],"conditions,":[60],"58":[62],"geriatric":[63],"patients.":[64],"cyclandelate":[66,80,168],"placebo":[68,86],"groups":[69],"(32":[70],"26":[72],"patients":[73,102,152],"respectively)":[74],"received":[75],"either":[76],"1,600":[77],"mg/day":[78],"fractional":[82],"doses,":[83],"or":[84],"identical-appearing":[85],"capsules--over":[87],"a":[88,170,200],"period":[89],"12":[91],"weeks.":[92],"During":[93],"initial":[95],"examination":[96],"every":[98],"four":[99],"weeks":[100,195],"thereafter,":[101],"were":[103,133],"assessed":[104],"for":[105,112,129,175,191,199],"possible":[106],"changes":[107],"vital":[109],"signs":[110],"evidence":[113,204],"adverse":[115],"reactions.":[116],"In":[117],"addition,":[118],"Sandoz":[120],"Clinical":[121,203],"Assessment-Geriatric":[122],"(SCAG)":[123],"Nurses":[126],"Observation":[127],"Scale":[128],"Inpatient":[130],"Evaluation":[131],"(NOSIE)":[132],"completed,":[134],"with":[135],"particular":[136],"attention":[137],"symptom":[139],"clusters.":[140],"A":[141],"final":[142],"global":[143],"assessment":[144],"made":[146],"which":[148],"physician":[150],"rated":[151],"according":[153],"their":[155],"overall":[156],"clinical":[157],"condition.":[158],"results":[160],"our":[162],"study":[163],"analysis":[165],"indicate":[166],"that":[167,206],"safe":[171],"effective":[173],"agent":[174],"treating":[176],"certain":[177],"senility":[180],"properly":[182],"selected":[183],"patients,":[184],"provided":[185],"therapy":[187],"carried":[189],"on":[190],"at":[192],"least":[193],"eight":[194],"and,":[196],"if":[197],"indicated,":[198],"longer":[201],"period.":[202],"suggests":[205],"prudent":[208],"use":[209],"drug":[212],"may":[213],"definitely":[214],"delay":[215],"deterioration.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
