{"id":"https://openalex.org/W1975782018","doi":"https://doi.org/10.3109/00016489409126102","title":"Nitrogen Dioxide-induced Eosinophilia and Mucosal Injury in the Nose of the Guinea Pig","display_name":"Nitrogen Dioxide-induced Eosinophilia and Mucosal Injury in the Nose of the Guinea Pig","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W1975782018","doi":"https://doi.org/10.3109/00016489409126102","mag":"1975782018","pmid":"https://pubmed.ncbi.nlm.nih.gov/7825439"},"language":"en","primary_location":{"id":"doi:10.3109/00016489409126102","doi":"https://doi.org/10.3109/00016489409126102","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00016489409126102","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111648943","display_name":"Yoshihiro Ohashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Ohashi","raw_affiliation_strings":["Department of Otolaryngology, Osaka City, University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City, University Medical School, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110247553","display_name":"Yoshiaki Nakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Nakai","raw_affiliation_strings":["Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086536243","display_name":"Yoshikazu Sugiura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikazu Sugiura","raw_affiliation_strings":["Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056652401","display_name":"Yoshiharu Ohno","orcid":"https://orcid.org/0000-0002-4431-1084","observed_orcids":["https://orcid.org/0000-0002-4431-1084"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiharu Ohno","raw_affiliation_strings":["Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hideki Okamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Okamoto","raw_affiliation_strings":["Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081640615","display_name":"Ayaki Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayaki Tanaka","raw_affiliation_strings":["Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016525421","display_name":"Yasushi Kakinoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Kakinoki","raw_affiliation_strings":["Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039216949","display_name":"Motoyo Hayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoyo Hayashi","raw_affiliation_strings":["Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City Unviersity Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3889,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.62873844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"114","issue":"5","first_page":"547","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.16169999539852142,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0689999982714653,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrogen-dioxide","display_name":"nitrogen dioxide","score":0.996999979019165},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nasal-mucosa","display_name":"nasal mucosa","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ciliary-activity","display_name":"ciliary activity","score":0.6579999923706055},{"id":"https://openalex.org/keywords/eosinophil-activation","display_name":"eosinophil activation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/epithelial-injury","display_name":"epithelial damage","score":0.9440000057220459},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hyperresponsiveness","display_name":"hyperreactivity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/guinea-pig-model","display_name":"guinea pig model","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.7368656992912292},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.7160065174102783},{"id":"https://openalex.org/C530467964","wikidata":"https://www.wikidata.org/wiki/Q1997","display_name":"Carbon dioxide","level":2,"score":0.6222040057182312},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.41480207443237305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3526664674282074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3507861793041229},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2952791452407837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21498453617095947},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15106523036956787},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009585","descriptor_name":"Nitrogen Dioxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/00016489409126102","doi":"https://doi.org/10.3109/00016489409126102","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00016489409126102","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},{"id":"pmid:7825439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7825439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oto-laryngologica","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1657740120","https://openalex.org/W1741936210","https://openalex.org/W2008282176","https://openalex.org/W2018123076","https://openalex.org/W2056736726","https://openalex.org/W2073171529","https://openalex.org/W2086534130","https://openalex.org/W2108495849","https://openalex.org/W2125781079","https://openalex.org/W2161752363","https://openalex.org/W2215212915","https://openalex.org/W2341069630"],"related_works":["https://openalex.org/W2086514024","https://openalex.org/W2323602825","https://openalex.org/W2136091393","https://openalex.org/W2161434512","https://openalex.org/W2111343552","https://openalex.org/W2079207345","https://openalex.org/W2074571426","https://openalex.org/W2090154062","https://openalex.org/W1988619534","https://openalex.org/W2158346870"],"abstract_inverted_index":{"Nitrogen":[0],"dioxide":[1,24,50,106,125],"exposure-induced":[2],"mucosal":[3],"pathology":[4],"of":[5,22,48,74,81,99,138],"the":[6,41,61,72,91,135],"guinea":[7,75],"pig":[8],"nose":[9,73],"was":[10],"studied.":[11],"Guinea":[12],"pigs":[13,76],"were":[14,69],"exposed":[15,77],"to":[16,45,78,90,97,109,128],"3":[17,46],"ppm":[18,21,47,80],"or":[19],"9":[20,79],"nitrogen":[23,49,82,105,124],"for":[25,33],"6":[26,30],"h":[27,39],"a":[28,85,115],"day,":[29],"times":[31],"weekly":[32],"2":[34],"weeks,":[35],"and":[36,56,63,93,111,130],"sacrificed":[37],"24":[38],"after":[40],"final":[42],"exposure.":[43],"Exposure":[44],"resulted":[51],"in":[52,71,114,134],"decreased":[53],"ciliary":[54],"activity":[55],"slight":[57],"eosinophil":[58,88],"accumulation":[59],"on":[60],"epithelium":[62,92],"submucosal":[64],"layer.":[65],"More":[66],"serious":[67],"pathologies":[68],"observed":[70],"dioxide,":[83],"including":[84],"more":[86],"prominent":[87],"influx":[89],"epithelial":[94],"injury":[95],"due":[96],"activation":[98],"eosinophils.":[100],"Epithelial":[101],"damage":[102],"induced":[103],"by":[104],"could":[107],"lead":[108],"hyperresponsiveness":[110,129],"may":[112,126],"result":[113],"prolonged":[116],"allergic":[117,139],"inflammation.":[118],"Our":[119],"study":[120],"suggests":[121],"that":[122],"environmental":[123],"contribute":[127],"thus":[131],"be":[132],"involved":[133],"increased":[136],"morbidity":[137],"rhinitis.":[140]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
