{"id":"https://openalex.org/W1975752067","doi":"https://doi.org/10.1517/13543784.14.9.1099","title":"The therapeutic potential of agents that inactivate myostatin","display_name":"The therapeutic potential of agents that inactivate myostatin","publication_year":2005,"publication_date":"2005-08-22","ids":{"openalex":"https://openalex.org/W1975752067","doi":"https://doi.org/10.1517/13543784.14.9.1099","mag":"1975752067","pmid":"https://pubmed.ncbi.nlm.nih.gov/16144494"},"language":"en","primary_location":{"id":"doi:10.1517/13543784.14.9.1099","doi":"https://doi.org/10.1517/13543784.14.9.1099","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.14.9.1099","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Amy Bishop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41125697","display_name":"AgResearch","ror":"https://ror.org/0124gwh94","country_code":"NZ","type":"government","lineage":["https://openalex.org/I41125697","https://openalex.org/I4405260297"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Amy Bishop","raw_affiliation_strings":["AgResearch, East Street, Private Bag 3123, Hamilton, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AgResearch, East Street, Private Bag 3123, Hamilton, New Zealand","institution_ids":["https://openalex.org/I41125697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081375937","display_name":"Ravi Kambadur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41125697","display_name":"AgResearch","ror":"https://ror.org/0124gwh94","country_code":"NZ","type":"government","lineage":["https://openalex.org/I41125697","https://openalex.org/I4405260297"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Ravi Kambadur","raw_affiliation_strings":["AgResearch, East Street, Private Bag 3123, Hamilton, New Zealand. Mridula.Sharma@agresearch.co.nz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AgResearch, East Street, Private Bag 3123, Hamilton, New Zealand. Mridula.Sharma@agresearch.co.nz","institution_ids":["https://openalex.org/I41125697"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105778527","display_name":"Mridula Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41125697","display_name":"AgResearch","ror":"https://ror.org/0124gwh94","country_code":"NZ","type":"government","lineage":["https://openalex.org/I41125697","https://openalex.org/I4405260297"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Mridula Sharma","raw_affiliation_strings":["AgResearch, East Street, Private Bag 3123, Hamilton, New Zealand. Mridula.Sharma@agresearch.co.nz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AgResearch, East Street, Private Bag 3123, Hamilton, New Zealand. Mridula.Sharma@agresearch.co.nz","institution_ids":["https://openalex.org/I41125697"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I41125697"],"apc_list":null,"apc_paid":null,"fwci":0.0271,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0171539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"9","first_page":"1099","last_page":"1106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.9390000104904175},{"id":"https://openalex.org/keywords/skeletal-muscle-mass","display_name":"skeletal muscle mass","score":0.7059999704360962},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.7440000176429749},{"id":"https://openalex.org/keywords/myoblast-proliferation-and-differentiation","display_name":"myoblast proliferation and differentiation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/therapeutic-agents","display_name":"therapeutic agents","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.9957461357116699},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.7010715007781982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5710082054138184},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5455867052078247},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5335370302200317},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.48307397961616516},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4743719696998596},{"id":"https://openalex.org/C3017707949","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Negative regulator","level":3,"score":0.47292664647102356},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4101802706718445},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40038231015205383},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3959653079509735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.362196683883667},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3235577344894409},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20596995949745178},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13633868098258972},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05733877420425415}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/13543784.14.9.1099","doi":"https://doi.org/10.1517/13543784.14.9.1099","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.14.9.1099","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},{"id":"pmid:16144494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16144494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on investigational drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313655","display_name":"Foundation for Research, Science and Technology","ror":"https://ror.org/04xvyyy18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W137188978","https://openalex.org/W1538521820","https://openalex.org/W1558226015","https://openalex.org/W1793391779","https://openalex.org/W1963588710","https://openalex.org/W1964832022","https://openalex.org/W1970674526","https://openalex.org/W1976957743","https://openalex.org/W1977410508","https://openalex.org/W1977664297","https://openalex.org/W1980011657","https://openalex.org/W1980213297","https://openalex.org/W1982422465","https://openalex.org/W1982626985","https://openalex.org/W1982715073","https://openalex.org/W1988027093","https://openalex.org/W1988711802","https://openalex.org/W1996732521","https://openalex.org/W1996832276","https://openalex.org/W1999303011","https://openalex.org/W2008869575","https://openalex.org/W2011408286","https://openalex.org/W2025463260","https://openalex.org/W2034074403","https://openalex.org/W2038839376","https://openalex.org/W2039709752","https://openalex.org/W2044440492","https://openalex.org/W2047974970","https://openalex.org/W2048134135","https://openalex.org/W2051613367","https://openalex.org/W2052009804","https://openalex.org/W2052508302","https://openalex.org/W2053079324","https://openalex.org/W2054027756","https://openalex.org/W2054368198","https://openalex.org/W2064895186","https://openalex.org/W2066467380","https://openalex.org/W2066735808","https://openalex.org/W2083700023","https://openalex.org/W2084480543","https://openalex.org/W2092051076","https://openalex.org/W2092106259","https://openalex.org/W2100345592","https://openalex.org/W2102470568","https://openalex.org/W2105608476","https://openalex.org/W2116961946","https://openalex.org/W2122594291","https://openalex.org/W2128303661","https://openalex.org/W2130122556","https://openalex.org/W2131304500","https://openalex.org/W2141725752","https://openalex.org/W2146431980","https://openalex.org/W2149993139","https://openalex.org/W2151078631","https://openalex.org/W2152128819","https://openalex.org/W2153289066","https://openalex.org/W2158254766","https://openalex.org/W2160199212","https://openalex.org/W2165868509","https://openalex.org/W2166300250","https://openalex.org/W2166877291","https://openalex.org/W2166947475","https://openalex.org/W2213824304","https://openalex.org/W2312522445","https://openalex.org/W2406377981","https://openalex.org/W4239540302"],"related_works":["https://openalex.org/W2766098981","https://openalex.org/W2126809879","https://openalex.org/W2134539889","https://openalex.org/W2466056406","https://openalex.org/W115909589","https://openalex.org/W1024279183","https://openalex.org/W4211003966","https://openalex.org/W2027579570","https://openalex.org/W112160195","https://openalex.org/W2049057335"],"abstract_inverted_index":{"Myostatin":[0,54],"is":[1,43],"a":[2,47],"member":[3],"of":[4,8,14,19,35,50,66,110,116],"the":[5,20,32,62,106,114],"TGF-beta":[6],"superfamily":[7],"secreted":[9],"growth":[10],"factors.":[11],"A":[12],"lack":[13],"functional":[15],"myostatin":[16,22,36,42,85,111],"or":[17,88],"inhibition":[18],"normal":[21],"function":[23],"results":[24,37],"in":[25,38,113],"an":[26,102],"increased":[27],"muscling":[28],"phenotype":[29],"and,":[30],"conversely,":[31],"systemic":[33],"administration":[34],"muscle":[39,52],"wasting.":[40],"Thus,":[41,78],"well":[44],"established":[45],"as":[46,94],"negative":[48],"regulator":[49],"skeletal":[51],"mass.":[53],"binds":[55],"to":[56,59,71,81],"cell-surface":[57],"receptors":[58],"inhibit":[60],"both":[61,73],"proliferation":[63],"and":[64,75,108],"differentiation":[65],"myoblasts.":[67],"Moreover,":[68],"it":[69],"functions":[70],"regulate":[72],"embryonic":[74],"post-natal":[76],"musculature.":[77],"potential":[79,109],"antagonists":[80,112],"myostatin,":[82],"whether":[83],"targeting":[84],"synthesis,":[86],"secretion":[87],"receptor":[89],"binding,":[90],"show":[91],"great":[92],"promise":[93],"therapies":[95],"against":[96],"muscle-wasting":[97,117],"diseases.":[98],"This":[99],"review":[100],"provides":[101],"expert":[103],"opinion":[104],"on":[105],"biology":[107],"treatment":[115],"disorders.":[118]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
