{"id":"https://openalex.org/W1975744882","doi":"https://doi.org/10.1242/dev.044826","title":"Modeling bistable cell-fate choices in theDrosophilaeye: qualitative and quantitative perspectives","display_name":"Modeling bistable cell-fate choices in theDrosophilaeye: qualitative and quantitative perspectives","publication_year":2010,"publication_date":"2010-06-22","ids":{"openalex":"https://openalex.org/W1975744882","doi":"https://doi.org/10.1242/dev.044826","mag":"1975744882","pmid":"https://pubmed.ncbi.nlm.nih.gov/20570936","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2889600"},"language":"en","primary_location":{"id":"doi:10.1242/dev.044826","doi":"https://doi.org/10.1242/dev.044826","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.044826","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2889600","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029700405","display_name":"Thomas G.W. Graham","orcid":"https://orcid.org/0000-0001-5189-4313","observed_orcids":["https://orcid.org/0000-0001-5189-4313"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas G. W. Graham","raw_affiliation_strings":["Ben May Department for Cancer Research, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ben May Department for Cancer Research, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019696985","display_name":"S. M. Ali Tabei","orcid":"https://orcid.org/0000-0003-1472-8388","observed_orcids":["https://orcid.org/0000-0003-1472-8388"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. Ali Tabei","raw_affiliation_strings":["James Franck Institute, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James Franck Institute, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075498364","display_name":"Aaron R. Dinner","orcid":"https://orcid.org/0000-0001-8328-6427","observed_orcids":["https://orcid.org/0000-0001-8328-6427"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron R. Dinner","raw_affiliation_strings":["James Franck Institute, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James Franck Institute, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033906250","display_name":"Ilaria Rebay","orcid":"https://orcid.org/0000-0002-2444-3864","observed_orcids":["https://orcid.org/0000-0002-2444-3864"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ilaria Rebay","raw_affiliation_strings":["Ben May Department for Cancer Research, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ben May Department for Cancer Research, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033906250"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.5085,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.41952895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"137","issue":"14","first_page":"2265","last_page":"2278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.041099999099969864,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.8100000023841858},{"id":"https://openalex.org/keywords/bistability","display_name":"bistability","score":0.8479999899864197},{"id":"https://openalex.org/keywords/drosophila-eye-development","display_name":"Drosophila eye development","score":0.8270000219345093},{"id":"https://openalex.org/keywords/positive-feedback","display_name":"positive feedback","score":0.6510000228881836},{"id":"https://openalex.org/keywords/multistability","display_name":"multistability","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cell-type-specification","display_name":"cell specification","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8637285232543945},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.8490115404129028},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.7770531177520752},{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.7007298469543457},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6760071516036987},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.441854327917099},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4183207154273987},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37740063667297363},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37028855085372925},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.35064393281936646},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.32972151041030884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27505365014076233},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15014901757240295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1465373933315277},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.07136392593383789},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1242/dev.044826","doi":"https://doi.org/10.1242/dev.044826","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.044826","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2889600","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2889600","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:20570936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20570936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.332.402","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.332.402","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dinner-group.uchicago.edu/mypdf/2010/GrahamDevelopment2010.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2889600","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2889600","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":149,"referenced_works":["https://openalex.org/W642006941","https://openalex.org/W1508305548","https://openalex.org/W1510241967","https://openalex.org/W1571843306","https://openalex.org/W1585692887","https://openalex.org/W1591273617","https://openalex.org/W1591423336","https://openalex.org/W1639000772","https://openalex.org/W1803466717","https://openalex.org/W1939368982","https://openalex.org/W1946177469","https://openalex.org/W1956460257","https://openalex.org/W1963900996","https://openalex.org/W1967159767","https://openalex.org/W1969547738","https://openalex.org/W1969862105","https://openalex.org/W1970396586","https://openalex.org/W1970986954","https://openalex.org/W1973908442","https://openalex.org/W1974520977","https://openalex.org/W1975876445","https://openalex.org/W1976178226","https://openalex.org/W1976631050","https://openalex.org/W1976798072","https://openalex.org/W1978182054","https://openalex.org/W1979400866","https://openalex.org/W1980661496","https://openalex.org/W1981288139","https://openalex.org/W1985607197","https://openalex.org/W1986060151","https://openalex.org/W1990631690","https://openalex.org/W1991425207","https://openalex.org/W1991631964","https://openalex.org/W1996861281","https://openalex.org/W1997409151","https://openalex.org/W1997814909","https://openalex.org/W2003286575","https://openalex.org/W2004517721","https://openalex.org/W2004543481","https://openalex.org/W2004801113","https://openalex.org/W2004891263","https://openalex.org/W2009607823","https://openalex.org/W2012794478","https://openalex.org/W2013424580","https://openalex.org/W2015826089","https://openalex.org/W2016097409","https://openalex.org/W2016423968","https://openalex.org/W2016546231","https://openalex.org/W2016782673","https://openalex.org/W2017840637","https://openalex.org/W2022891974","https://openalex.org/W2023485590","https://openalex.org/W2027703497","https://openalex.org/W2028875328","https://openalex.org/W2029146318","https://openalex.org/W2029516652","https://openalex.org/W2031822229","https://openalex.org/W2032682319","https://openalex.org/W2032799661","https://openalex.org/W2033901847","https://openalex.org/W2035528013","https://openalex.org/W2039009882","https://openalex.org/W2039657602","https://openalex.org/W2040107912","https://openalex.org/W2043854809","https://openalex.org/W2044773122","https://openalex.org/W2045223401","https://openalex.org/W2047578520","https://openalex.org/W2053009960","https://openalex.org/W2053076831","https://openalex.org/W2056948143","https://openalex.org/W2057233281","https://openalex.org/W2059954649","https://openalex.org/W2063206483","https://openalex.org/W2068089675","https://openalex.org/W2070050569","https://openalex.org/W2070531819","https://openalex.org/W2073675468","https://openalex.org/W2076767381","https://openalex.org/W2077210071","https://openalex.org/W2077905496","https://openalex.org/W2081257553","https://openalex.org/W2081282343","https://openalex.org/W2081848717","https://openalex.org/W2087234479","https://openalex.org/W2087752456","https://openalex.org/W2088305049","https://openalex.org/W2088510647","https://openalex.org/W2089559354","https://openalex.org/W2090698995","https://openalex.org/W2091643574","https://openalex.org/W2092353871","https://openalex.org/W2092502264","https://openalex.org/W2094643072","https://openalex.org/W2099521105","https://openalex.org/W2099530148","https://openalex.org/W2101713686","https://openalex.org/W2102086569","https://openalex.org/W2102171053","https://openalex.org/W2102496594","https://openalex.org/W2103902945","https://openalex.org/W2104499325","https://openalex.org/W2105057212","https://openalex.org/W2110823478","https://openalex.org/W2111760008","https://openalex.org/W2114418253","https://openalex.org/W2121216331","https://openalex.org/W2122054690","https://openalex.org/W2123880844","https://openalex.org/W2123911104","https://openalex.org/W2127992319","https://openalex.org/W2128313698","https://openalex.org/W2130746708","https://openalex.org/W2133883628","https://openalex.org/W2134160463","https://openalex.org/W2134759932","https://openalex.org/W2137031731","https://openalex.org/W2141545875","https://openalex.org/W2142691347","https://openalex.org/W2144804667","https://openalex.org/W2145641640","https://openalex.org/W2145655469","https://openalex.org/W2146826296","https://openalex.org/W2150671475","https://openalex.org/W2151874656","https://openalex.org/W2152611630","https://openalex.org/W2155394790","https://openalex.org/W2155408323","https://openalex.org/W2157479465","https://openalex.org/W2159205683","https://openalex.org/W2161224111","https://openalex.org/W2161251399","https://openalex.org/W2161304688","https://openalex.org/W2162669522","https://openalex.org/W2163049149","https://openalex.org/W2165625463","https://openalex.org/W2167889770","https://openalex.org/W2168221215","https://openalex.org/W2168364602","https://openalex.org/W2181885838","https://openalex.org/W2186225761","https://openalex.org/W2187785265","https://openalex.org/W2188222617","https://openalex.org/W2327883350","https://openalex.org/W2343326981","https://openalex.org/W2361838659","https://openalex.org/W2428846903","https://openalex.org/W4232042630","https://openalex.org/W4239457632"],"related_works":["https://openalex.org/W7099651910","https://openalex.org/W2038120653","https://openalex.org/W2286997991","https://openalex.org/W2783380135","https://openalex.org/W4409109044","https://openalex.org/W1759354465","https://openalex.org/W41869362","https://openalex.org/W2087563358","https://openalex.org/W2479053914","https://openalex.org/W2950519240"],"abstract_inverted_index":{"A":[0],"major":[1],"goal":[2],"of":[3,34,46,86],"developmental":[4],"biology":[5],"is":[6],"to":[7,77],"understand":[8,78],"the":[9,31,38,44,47,81],"molecular":[10],"mechanisms":[11],"whereby":[12],"genetic":[13],"signaling":[14,49],"networks":[15],"establish":[16],"and":[17,37,69,79],"maintain":[18],"distinct":[19],"cell":[20],"types":[21],"within":[22],"multicellular":[23],"organisms.":[24],"Here,":[25],"we":[26],"review":[27],"cell-fate":[28,67],"decisions":[29],"in":[30,66],"developing":[32],"eye":[33],"Drosophila":[35],"melanogaster":[36],"experimental":[39],"results":[40],"that":[41,54],"have":[42],"revealed":[43],"topology":[45],"underlying":[48],"circuitries.":[50],"We":[51],"then":[52],"propose":[53],"switch-like":[55],"network":[56],"motifs":[57],"based":[58],"on":[59],"positive":[60],"feedback":[61],"play":[62],"a":[63],"central":[64],"role":[65],"choice,":[68],"discuss":[70],"how":[71],"mathematical":[72],"modeling":[73],"can":[74],"be":[75],"used":[76],"predict":[80],"bistable":[82],"or":[83],"multistable":[84],"behavior":[85],"such":[87],"networks.":[88]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
