{"id":"https://openalex.org/W1975711024","doi":"https://doi.org/10.3810/psm.2010.06.1781","title":"Hylan G-F 20 Improves Hip Osteoarthritis: A Prospective, Randomized Study","display_name":"Hylan G-F 20 Improves Hip Osteoarthritis: A Prospective, Randomized Study","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W1975711024","doi":"https://doi.org/10.3810/psm.2010.06.1781","mag":"1975711024","pmid":"https://pubmed.ncbi.nlm.nih.gov/20631462"},"language":"en","primary_location":{"id":"doi:10.3810/psm.2010.06.1781","doi":"https://doi.org/10.3810/psm.2010.06.1781","is_oa":false,"landing_page_url":"https://doi.org/10.3810/psm.2010.06.1781","pdf_url":null,"source":{"id":"https://openalex.org/S136800548","display_name":"The Physician and Sportsmedicine","issn_l":"0091-3847","issn":["0091-3847","2326-3660"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Physician and Sportsmedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026212864","display_name":"Andrew I. Spitzer","orcid":"https://orcid.org/0000-0002-5263-6540","observed_orcids":["https://orcid.org/0000-0002-5263-6540"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew I. Spitzer","raw_affiliation_strings":[", , , , ","Cedars-Sinai Orthopedic Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", , , , ","institution_ids":[]},{"raw_affiliation_string":"Cedars-Sinai Orthopedic Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062298769","display_name":"Barry I. Bockow","orcid":"https://orcid.org/0000-0002-3984-2024","observed_orcids":["https://orcid.org/0000-0002-3984-2024"]},"institutions":[{"id":"https://openalex.org/I4210150792","display_name":"Arthritis Northwest","ror":"https://ror.org/05vctz765","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry I. Bockow","raw_affiliation_strings":["Arthritis Northwest, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Northwest, Seattle, WA","institution_ids":["https://openalex.org/I4210150792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090739352","display_name":"Victoria Anne Brander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria A. Brander","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Northwestern Orthopedic Institute, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Northwestern Orthopedic Institute, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James W. Yates","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100184","display_name":"Conway Regional Health System","ror":"https://ror.org/019n7yz73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James W. Yates","raw_affiliation_strings":["Conway Medical Center, Conway, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conway Medical Center, Conway, SC","institution_ids":["https://openalex.org/I4210100184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009994688","display_name":"Daryl K. MacCarter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daryl K. MacCarter","raw_affiliation_strings":["Idaho Arthritis and Osteoporosis Center, Meridian, ID"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Idaho Arthritis and Osteoporosis Center, Meridian, ID","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008651329","display_name":"Garland K. Gudger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092440","display_name":"Hughston Clinic","ror":"https://ror.org/00g4tw789","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210092440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garland K. Gudger","raw_affiliation_strings":["The Hughston Foundation, Columbus, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hughston Foundation, Columbus, GA","institution_ids":["https://openalex.org/I4210092440"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephanie Haller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie Haller","raw_affiliation_strings":["Genzyme Biosurgery, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Biosurgery, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109202089","display_name":"Stephen L. Lake","orcid":"https://orcid.org/0009-0001-8154-8515","observed_orcids":["https://orcid.org/0009-0001-8154-8515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen L. Lake","raw_affiliation_strings":["Genzyme Biosurgery, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Biosurgery, Cambridge, MA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048294886","display_name":"Daniel B. Magilavy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel B. Magilavy","raw_affiliation_strings":["Genzyme Biosurgery, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Biosurgery, Cambridge, MA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5026212864"],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":null,"apc_paid":null,"fwci":0.739,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.71782986,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"2","first_page":"35","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11218","display_name":"Hip disorders and treatments","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hip-osteoarthritis","display_name":"hip osteoarthritis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hylan-g-f-20","display_name":"hylan G-F 20","score":0.9929999709129333},{"id":"https://openalex.org/keywords/methylprednisolone-acetate","display_name":"methylprednisolone acetate","score":0.8999999761581421},{"id":"https://openalex.org/keywords/intra-articular-injection","display_name":"intra-articular injection","score":0.984000027179718},{"id":"https://openalex.org/keywords/kellgren-lawrence-grade","display_name":"Kellgren-Lawrence grade","score":0.9290000200271606},{"id":"https://openalex.org/keywords/womac","display_name":"WOMAC","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pain-and-function","display_name":"pain and function","score":0.6600000262260437},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.5299999713897705},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.7940000295639038},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.87615966796875},{"id":"https://openalex.org/C2779286237","wikidata":"https://www.wikidata.org/wiki/Q3569749","display_name":"WOMAC","level":4,"score":0.8591419458389282},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8546914458274841},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.6509436964988708},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.561999499797821},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5384935736656189},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5250758528709412},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5219956636428833},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4346836805343628},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3551748991012573},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.06890633702278137},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05686897039413452}],"mesh":[{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007270","descriptor_name":"Injections, Intra-Articular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015207","descriptor_name":"Osteoarthritis, Hip","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3810/psm.2010.06.1781","doi":"https://doi.org/10.3810/psm.2010.06.1781","is_oa":false,"landing_page_url":"https://doi.org/10.3810/psm.2010.06.1781","pdf_url":null,"source":{"id":"https://openalex.org/S136800548","display_name":"The Physician and Sportsmedicine","issn_l":"0091-3847","issn":["0091-3847","2326-3660"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Physician and Sportsmedicine","raw_type":"journal-article"},{"id":"pmid:20631462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20631462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Physician and sportsmedicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1508800778","https://openalex.org/W1947407367","https://openalex.org/W1951915552","https://openalex.org/W1955303227","https://openalex.org/W1967057044","https://openalex.org/W1979403242","https://openalex.org/W1982778775","https://openalex.org/W1987520739","https://openalex.org/W1990430550","https://openalex.org/W1995574208","https://openalex.org/W2021143537","https://openalex.org/W2042174179","https://openalex.org/W2047734268","https://openalex.org/W2054036955","https://openalex.org/W2056132177","https://openalex.org/W2057647525","https://openalex.org/W2091065691","https://openalex.org/W2091455703","https://openalex.org/W2093449713","https://openalex.org/W2096018352","https://openalex.org/W2096388167","https://openalex.org/W2100161403","https://openalex.org/W2108365470","https://openalex.org/W2113709332","https://openalex.org/W2113737049","https://openalex.org/W2118502261","https://openalex.org/W2120377396","https://openalex.org/W2129152730","https://openalex.org/W2141363952","https://openalex.org/W2142660126","https://openalex.org/W2147251490","https://openalex.org/W2153035837","https://openalex.org/W2161311893","https://openalex.org/W2161344815","https://openalex.org/W2167792025","https://openalex.org/W2188180894","https://openalex.org/W2189291174","https://openalex.org/W2274722622","https://openalex.org/W2413800735","https://openalex.org/W2416800792","https://openalex.org/W4248226706"],"related_works":["https://openalex.org/W1995574208","https://openalex.org/W1990430550","https://openalex.org/W2584035070","https://openalex.org/W3204867267","https://openalex.org/W2528410128","https://openalex.org/W2108365470","https://openalex.org/W2081476534","https://openalex.org/W7025045793","https://openalex.org/W2413800735","https://openalex.org/W2889766544"],"abstract_inverted_index":{"We":[0],"compared":[1],"the":[2,119],"efficacy":[3],"and":[4,57,70,77,81,89,97,114,166,173,189,206,216],"safety":[5,215],"of":[6,38,53,211],"intra-articular":[7],"hylan":[8,39,140,153,170],"G-F":[9,40,141,154,171,198],"20":[10,41,142,155,172,199],"with":[11,152,160,177,192,209,213],"methylprednisolone":[12],"acetate":[13],"(MPA)":[14],"for":[15,139,146,226],"treating":[16,227],"symptomatic":[17],"Kellgren-Lawrence":[18],"grade":[19],"(KLG)":[20],"2":[21,44,61,194],"or":[22,50,195],"3":[23],"hip":[24,228],"osteoarthritis":[25],"in":[26,122,158,175,204],"a":[27],"prospective,":[28],"randomized,":[29],"multicenter,":[30],"double-blind":[31],"trial":[32],"(N":[33],"=":[34,48,65,104],"313).":[35],"Two":[36],"injections":[37],"were":[42,85,108,116,150,167,185],"administered":[43],"weeks":[45,62,91],"apart":[46],"(n":[47,64],"150),":[49],"1":[51,58],"injection":[52,60],"40":[54],"mg":[55],"MPA":[56,157,174],"sham":[59],"later":[63],"155).":[66],"The":[67],"Western":[68],"Ontario":[69],"McMaster":[71],"Universities":[72],"Arthritis":[73],"Index":[74],"(WOMAC)":[75],"(total":[76],"subscale),":[78],"clinician":[79],"observations,":[80],"patient":[82],"global":[83],"assessments":[84],"collected":[86],"at":[87,90],"baseline":[88],"4,":[92],"8,":[93],"12,":[94],"16,":[95],"20,":[96],"26":[98],"(intent-to-treat":[99],"population":[100],"was":[101],"analyzed;":[102],"n":[103],"305).":[105],"Responder":[106],"rates":[107,149],"assessed":[109],"by":[110,118,136],"WOMAC":[111,133],"domain":[112],"A,":[113],"criteria":[115],"established":[117],"Outcome":[120],"Measures":[121],"Rheumatology":[123],"Clinical":[124],"Trials-Osteoarthritis":[125],"Research":[126],"Society":[127],"International":[128],"(OMERACT-OARSI).":[129],"At":[130],"week":[131],"26,":[132],"A":[134],"improved":[135],"16.6":[137],"mm":[138,145],"versus":[143,156],"13.6":[144],"MPA.":[147],"Response":[148],"higher":[151],"patients":[159,176,191],"more":[161],"advanced":[162,179],"disease":[163,180],"(KLG":[164,181],"3)":[165],"similar":[168,186],"between":[169,187,190],"less":[178],"2).":[182],"Adverse":[183],"events":[184],"groups":[188],"KLG":[193],"3.":[196],"Hylan":[197],"provided":[200],"clinically":[201],"meaningful":[202],"improvements":[203],"pain":[205],"function,":[207],"comparable":[208],"those":[210],"MPA,":[212],"good":[214],"tolerability.":[217],"Thus,":[218],"we":[219],"conclude":[220],"it":[221],"is":[222],"an":[223],"appropriate":[224],"option":[225],"osteoarthritis.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}