{"id":"https://openalex.org/W1975596553","doi":"https://doi.org/10.1038/nchembio850","title":"Structure of acid \u03b2-glucosidase with pharmacological chaperone provides insight into Gaucher disease","display_name":"Structure of acid \u03b2-glucosidase with pharmacological chaperone provides insight into Gaucher disease","publication_year":2006,"publication_date":"2006-12-24","ids":{"openalex":"https://openalex.org/W1975596553","doi":"https://doi.org/10.1038/nchembio850","mag":"1975596553","pmid":"https://pubmed.ncbi.nlm.nih.gov/17187079"},"language":"en","primary_location":{"id":"doi:10.1038/nchembio850","doi":"https://doi.org/10.1038/nchembio850","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nchembio850","pdf_url":null,"source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075604712","display_name":"Raquel L. Lieberman","orcid":"https://orcid.org/0000-0001-9345-3735","observed_orcids":["https://orcid.org/0000-0001-9345-3735"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raquel L Lieberman","raw_affiliation_strings":["Structural Neurology Lab, Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA","Structural Neurology Lab at the Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Neurology Lab, Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Structural Neurology Lab at the Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034612091","display_name":"Brandon A. Wustman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134439","display_name":"Amicus Therapeutics (United States)","ror":"https://ror.org/0328xw886","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon A Wustman","raw_affiliation_strings":["Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA","institution_ids":["https://openalex.org/I4210134439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054725058","display_name":"Pedro E. Huertas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092658","display_name":"Harvard\u2013MIT Division of Health Sciences and Technology","ror":"https://ror.org/00jjeh629","country_code":"US","type":"education","lineage":["https://openalex.org/I4210092658"]},{"id":"https://openalex.org/I4210134439","display_name":"Amicus Therapeutics (United States)","ror":"https://ror.org/0328xw886","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134439"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro Huertas","raw_affiliation_strings":["Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA","The Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Building E25-519, 71 Massachusetts Avenue, Cambridge, 02139, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA","institution_ids":["https://openalex.org/I4210134439"]},{"raw_affiliation_string":"The Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Building E25-519, 71 Massachusetts Avenue, Cambridge, 02139, Massachusetts, USA","institution_ids":["https://openalex.org/I4210092658","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029300594","display_name":"Allan C. Powe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134439","display_name":"Amicus Therapeutics (United States)","ror":"https://ror.org/0328xw886","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan C Powe","raw_affiliation_strings":["Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA","institution_ids":["https://openalex.org/I4210134439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030024227","display_name":"C.W. Pine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134439","display_name":"Amicus Therapeutics (United States)","ror":"https://ror.org/0328xw886","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corey W Pine","raw_affiliation_strings":["Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA","institution_ids":["https://openalex.org/I4210134439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104623070","display_name":"Richie Khanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134439","display_name":"Amicus Therapeutics (United States)","ror":"https://ror.org/0328xw886","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richie Khanna","raw_affiliation_strings":["Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amicus Therapeutics, 6 Cedar Brook Drive, Cranbury, 08512, New Jersey, USA","institution_ids":["https://openalex.org/I4210134439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000268173","display_name":"Michael G. Schlossmacher","orcid":"https://orcid.org/0000-0002-0394-0300","observed_orcids":["https://orcid.org/0000-0002-0394-0300","https://orcid.org/0000-0003-0912-0845"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G Schlossmacher","raw_affiliation_strings":["Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014900252","display_name":"Dagmar Ringe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dagmar Ringe","raw_affiliation_strings":["Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA","Rosenstiel Center for Basic Biomedical Sciences, Brandeis University, 415 South Street, Waltham, 02454, Massachusetts, USA","Structural Neurology Lab at the Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Rosenstiel Center for Basic Biomedical Sciences, Brandeis University, 415 South Street, Waltham, 02454, Massachusetts, USA","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Structural Neurology Lab at the Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007934367","display_name":"Gregory A. Petsko","orcid":"https://orcid.org/0000-0003-3668-3694","observed_orcids":["https://orcid.org/0000-0003-3668-3694"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory A Petsko","raw_affiliation_strings":["Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA","Rosenstiel Center for Basic Biomedical Sciences, Brandeis University, 415 South Street, Waltham, 02454, Massachusetts, USA","Structural Neurology Lab at the Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Rosenstiel Center for Basic Biomedical Sciences, Brandeis University, 415 South Street, Waltham, 02454, Massachusetts, USA","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Structural Neurology Lab at the Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5007934367"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I6902469"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":9.2043,"has_fulltext":false,"cited_by_count":248,"citation_normalized_percentile":{"value":0.98437048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"3","issue":"2","first_page":"101","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaucher-disease","display_name":"Gaucher disease","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glucocerebrosidase","display_name":"glucocerebrosidase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pharmacological-chaperones","display_name":"pharmacological chaperones","score":0.828000009059906},{"id":"https://openalex.org/keywords/isofagomine","display_name":"isofagomine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/n370s-mutation","display_name":"N370S mutation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lysosome-trafficking","display_name":"lysosomal trafficking","score":0.7940000295639038},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.8450000286102295},{"id":"https://openalex.org/keywords/lysosomal-storage-disorders","display_name":"lysosomal storage disease","score":0.6190000176429749},{"id":"https://openalex.org/keywords/enzyme-replacement-therapy","display_name":"enzyme replacement therapy","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.745036780834198},{"id":"https://openalex.org/C61397870","wikidata":"https://www.wikidata.org/wiki/Q1069458","display_name":"Chemical chaperone","level":4,"score":0.682963490486145},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6005244851112366},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5391234755516052},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.48043179512023926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4699777662754059},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4521194100379944},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.4439045786857605},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4429720342159271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41081029176712036},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41059035062789917},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18748590350151062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1642511785030365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005776","descriptor_name":"Gaucher Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005776","descriptor_name":"Gaucher Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005776","descriptor_name":"Gaucher Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050112","descriptor_name":"Imino Pyranoses","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050112","descriptor_name":"Imino Pyranoses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nchembio850","doi":"https://doi.org/10.1038/nchembio850","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nchembio850","pdf_url":null,"source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},{"id":"pmid:17187079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17187079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature chemical biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1483358522","https://openalex.org/W1525577371","https://openalex.org/W1539796472","https://openalex.org/W1940027108","https://openalex.org/W1965705234","https://openalex.org/W1978453396","https://openalex.org/W1983928893","https://openalex.org/W1990520168","https://openalex.org/W1994828324","https://openalex.org/W2001641653","https://openalex.org/W2007826813","https://openalex.org/W2010687395","https://openalex.org/W2011709758","https://openalex.org/W2015309952","https://openalex.org/W2019895460","https://openalex.org/W2034690243","https://openalex.org/W2039884825","https://openalex.org/W2049707254","https://openalex.org/W2054646490","https://openalex.org/W2055570767","https://openalex.org/W2109854496","https://openalex.org/W2114367386","https://openalex.org/W2124305857","https://openalex.org/W2125281037","https://openalex.org/W2126997204","https://openalex.org/W2127513771","https://openalex.org/W2142115754","https://openalex.org/W2144081223","https://openalex.org/W2144450046","https://openalex.org/W2144998676"],"related_works":["https://openalex.org/W1990841558","https://openalex.org/W1533651529","https://openalex.org/W2038961641","https://openalex.org/W2099739812","https://openalex.org/W2116563547","https://openalex.org/W2086597163","https://openalex.org/W1965705234","https://openalex.org/W2296031899","https://openalex.org/W2103458534","https://openalex.org/W1758125525"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}