{"id":"https://openalex.org/W197555802","doi":null,"title":"Safety and Efficacy of a Hepatitis E Virus Vaccine Conducted in Nepal","display_name":"Safety and Efficacy of a Hepatitis E Virus Vaccine Conducted in Nepal","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W197555802","mag":"197555802"},"language":"en","primary_location":{"id":"pmh:ADA481583","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA481583","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065178790","display_name":"Mrigendra Prasad Shrestha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mrigendra P. Shrestha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110660094","display_name":"Robert McN. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert McN. Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103233977","display_name":"Sanjaya Kumar Shrestha","orcid":"https://orcid.org/0000-0003-2860-6293","observed_orcids":["https://orcid.org/0000-0003-2860-6293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjaya Kumar Shrestha","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2860-6293","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038579685","display_name":"Khin Saw Aye Myint","orcid":"https://orcid.org/0000-0002-2087-7331","observed_orcids":["https://orcid.org/0000-0002-2087-7331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khin Saw Aye Myint","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2087-7331","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038317666","display_name":"M. P. Mammen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. P. Mammen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D Joshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Joshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006369287","display_name":"Gyan Bahadur Thapa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gyan Bahadur Thapa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101515619","display_name":"Narbada Thapa","orcid":"https://orcid.org/0000-0001-9527-4343","observed_orcids":["https://orcid.org/0000-0001-9527-4343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narbada Thapa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9527-4343","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070355025","display_name":"David M. Fourneau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M. Fourneau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004988182","display_name":"Assad Safary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Assad Safary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082800560","display_name":"Bruce L. Innis","orcid":"https://orcid.org/0000-0002-1753-7248","observed_orcids":["https://orcid.org/0000-0002-1753-7248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce L. Innis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1753-7248","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029126593","display_name":"Robert A. Kuschner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A. Kuschner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076643869","display_name":"JITVIMOL SERIWATANA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Seriwatana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107835530","display_name":"Timothy P. Endy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy P. Endy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079778326","display_name":"David W. Vaughn","orcid":"https://orcid.org/0000-0002-1396-1690","observed_orcids":["https://orcid.org/0000-0002-1396-1690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David W. Vaughn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1396-1690","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01684556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12025","display_name":"Hepatitis Viruses Studies and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12025","display_name":"Hepatitis Viruses Studies and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-e-virus","display_name":"hepatitis E virus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/recombinant-protein-vaccine","display_name":"recombinant protein vaccine","score":0.7929999828338623},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.9169999957084656},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/military-personnel","display_name":"military personnel","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nepal","display_name":"Nepal","score":0.39800000190734863},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5189999938011169},{"id":"https://openalex.org/keywords/hospital-based-surveillance","display_name":"hospital surveillance","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8470197916030884},{"id":"https://openalex.org/C2780799908","wikidata":"https://www.wikidata.org/wiki/Q3553093","display_name":"Hepatitis A vaccine","level":4,"score":0.843375563621521},{"id":"https://openalex.org/C2775876817","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis A","level":3,"score":0.6876469850540161},{"id":"https://openalex.org/C2780777367","wikidata":"https://www.wikidata.org/wiki/Q24757533","display_name":"Hepatitis E virus","level":4,"score":0.6821367740631104},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5924750566482544},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5032059550285339},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5019400119781494},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4935404062271118},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4793558716773987},{"id":"https://openalex.org/C2781096931","wikidata":"https://www.wikidata.org/wiki/Q326643","display_name":"Hepatitis E","level":4,"score":0.4459828734397888},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.4440488815307617},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.42433929443359375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3300662040710449},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3182697296142578},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07692417502403259},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.06610003113746643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0630873441696167},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06196275353431702},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:ADA481583","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA481583","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},{"id":"mag:197555802","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/sti/pdfs/ADA481583.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W33302803","https://openalex.org/W1515656514","https://openalex.org/W1569826234","https://openalex.org/W1982052231","https://openalex.org/W1983225666","https://openalex.org/W2012557023","https://openalex.org/W2018855888","https://openalex.org/W2021058340","https://openalex.org/W2063109692","https://openalex.org/W2083988338","https://openalex.org/W2094608386","https://openalex.org/W2109411415","https://openalex.org/W2116500812","https://openalex.org/W2142189511","https://openalex.org/W2143303971","https://openalex.org/W2149894749","https://openalex.org/W2151920748","https://openalex.org/W2398003483"],"related_works":["https://openalex.org/W7100898814","https://openalex.org/W2023136941","https://openalex.org/W1993001053","https://openalex.org/W2944011242","https://openalex.org/W2094735900","https://openalex.org/W2328333865","https://openalex.org/W2414899616","https://openalex.org/W4239435197","https://openalex.org/W2118232956","https://openalex.org/W2136175711"],"abstract_inverted_index":{"Hepatitis":[0],"E":[1,19,95],"virus":[2],"(HEV)":[3],"causes":[4],"hepatitis":[5,18,86,94],"E,":[6],"a":[7,33,40],"public":[8],"health":[9],"problem":[10],"in":[11,23,39],"many":[12],"developing":[13],"countries.":[14],"Several":[15],"outbreaks":[16],"of":[17,32,62],"have":[20],"been":[21],"reported":[22],"military":[24],"environments.":[25],"We":[26],"evaluated":[27],"the":[28,64],"safety":[29],"and":[30,75,78,87],"efficacy":[31],"HEV":[34,54],"recombinant":[35],"protein":[36],"(rHEV)":[37],"vaccine":[38,66,99],"randomized,":[41],"double-blinded,":[42],"placebo-controlled":[43],"trial.":[44],"In":[45],"Nepal,":[46],"we":[47],"studied":[48],"2,000":[49],"healthy":[50],"adults":[51],"susceptible":[52],"to":[53,58,83],"who":[55],"were":[56,81],"randomized":[57],"receive":[59],"3":[60,98],"doses":[61],"either":[63],"rHEV":[65],"(1,000)":[67,70],"or":[68],"placebo":[69],"at":[71],"months":[72],"0,":[73],"1":[74],"6.":[76],"Active":[77],"hospital":[79],"surveillance":[80],"used":[82],"identify":[84],"acute":[85],"adverse":[88],"events.":[89],"The":[90],"primary":[91],"endpoint":[92],"was":[93],"occurring":[96],"after":[97],"doses.":[100]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}