{"id":"https://openalex.org/W1975550102","doi":"https://doi.org/10.1111/j.1471-4159.2009.05891.x","title":"Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: implications for multiple sclerosis","display_name":"Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: implications for multiple sclerosis","publication_year":2009,"publication_date":"2009-02-16","ids":{"openalex":"https://openalex.org/W1975550102","doi":"https://doi.org/10.1111/j.1471-4159.2009.05891.x","mag":"1975550102","pmid":"https://pubmed.ncbi.nlm.nih.gov/19226373","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2756289"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.2009.05891.x","doi":"https://doi.org/10.1111/j.1471-4159.2009.05891.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2009.05891.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2756289/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109512330","display_name":"Amy Bishop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amy Bishop","raw_affiliation_strings":["Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA. bishopa@uah.edu","Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama 35899 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA. bishopa@uah.edu","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama 35899 USA","institution_ids":["https://openalex.org/I82495205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053355978","display_name":"Kimberly Green Hobbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Green Hobbs","raw_affiliation_strings":["Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899","Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA","institution_ids":["https://openalex.org/I82495205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008048918","display_name":"Asuka Eguchi","orcid":"https://orcid.org/0000-0003-3010-0275","observed_orcids":["https://orcid.org/0000-0003-3010-0275"]},"institutions":[{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asuka Eguchi","raw_affiliation_strings":["Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899","Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA","institution_ids":["https://openalex.org/I82495205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028535568","display_name":"Stephanie Jeffrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Jeffrey","raw_affiliation_strings":["Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA","institution_ids":["https://openalex.org/I82495205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021934308","display_name":"Lorraine Smallwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorraine Smallwood","raw_affiliation_strings":["Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA","institution_ids":["https://openalex.org/I82495205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053506815","display_name":"Cedona Pennie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cedona Pennie","raw_affiliation_strings":["Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899","Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA","institution_ids":["https://openalex.org/I82495205"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Anderson","raw_affiliation_strings":["Cherokee Labsystems, Huntsville, AL 35899","Cherokee Labsystems, Huntsville, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cherokee Labsystems, Huntsville, AL 35899","institution_ids":[]},{"raw_affiliation_string":"Cherokee Labsystems, Huntsville, Alabama, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037134872","display_name":"\u00c1lvaro G. Est\u00e9vez","orcid":"https://orcid.org/0000-0003-2671-3773","observed_orcids":["https://orcid.org/0000-0003-2671-3773"]},"institutions":[{"id":"https://openalex.org/I4210117944","display_name":"Burke Medical Research Institute","ror":"https://ror.org/02sp1z620","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117944"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvaro G. Est\u00e9vez","raw_affiliation_strings":["Burke Medical Research Institute, Weill Cornell Medical College","Burke Medical Research Institute Weill Cornell Medical College, White Plains, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burke Medical Research Institute, Weill Cornell Medical College","institution_ids":["https://openalex.org/I4210117944","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Burke Medical Research Institute Weill Cornell Medical College, White Plains, New York, USA","institution_ids":["https://openalex.org/I4210117944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109512330"],"corresponding_institution_ids":["https://openalex.org/I82495205"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.3185,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.77248575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"109","issue":"1","first_page":"93","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.27730000019073486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.27730000019073486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.2728999853134155,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.2572999894618988,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8209999799728394},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.8690000176429749},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.8880000114440918},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.9700000286102295},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.7120000123977661},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.4410000145435333},{"id":"https://openalex.org/keywords/spermine-nonoate","display_name":"spermine NONOate","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.8396570682525635},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.7600641846656799},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.557249128818512},{"id":"https://openalex.org/C2779525624","wikidata":"https://www.wikidata.org/wiki/Q225595","display_name":"Reactive nitrogen species","level":3,"score":0.5361195802688599},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5262136459350586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5103134512901306},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.47771787643432617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40941011905670166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40556415915489197},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.3746510446071625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37356868386268616},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3049468994140625},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2584540843963623},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.25256654620170593},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21422243118286133},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15184399485588074},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14426004886627197}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026361","descriptor_name":"Reactive Nitrogen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030421","descriptor_name":"Peroxynitrous Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1471-4159.2009.05891.x","doi":"https://doi.org/10.1111/j.1471-4159.2009.05891.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2009.05891.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:19226373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19226373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:2756289","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2756289/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurochem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2756289","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2756289/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurochem","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1698327947","display_name":"Elucidation of nitric oxide resistance mechanisms in motor neurons","funder_award_id":"R15NS057803","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W24824111","https://openalex.org/W141722433","https://openalex.org/W1484194388","https://openalex.org/W1485043634","https://openalex.org/W1573593065","https://openalex.org/W1575731167","https://openalex.org/W1829813323","https://openalex.org/W1964493422","https://openalex.org/W1967207824","https://openalex.org/W1967505783","https://openalex.org/W1967836873","https://openalex.org/W1969109328","https://openalex.org/W1970046036","https://openalex.org/W1970380641","https://openalex.org/W1974366107","https://openalex.org/W1978098707","https://openalex.org/W1987215169","https://openalex.org/W1989638556","https://openalex.org/W1993835369","https://openalex.org/W1994937692","https://openalex.org/W1996200572","https://openalex.org/W1996350615","https://openalex.org/W2005596024","https://openalex.org/W2007354513","https://openalex.org/W2008419769","https://openalex.org/W2008560021","https://openalex.org/W2010233410","https://openalex.org/W2010546048","https://openalex.org/W2020355061","https://openalex.org/W2022473067","https://openalex.org/W2025723657","https://openalex.org/W2026943045","https://openalex.org/W2027291501","https://openalex.org/W2028812421","https://openalex.org/W2033240573","https://openalex.org/W2039709703","https://openalex.org/W2041397264","https://openalex.org/W2043836288","https://openalex.org/W2044196027","https://openalex.org/W2049565893","https://openalex.org/W2050348658","https://openalex.org/W2058214824","https://openalex.org/W2061969256","https://openalex.org/W2062329216","https://openalex.org/W2066097266","https://openalex.org/W2074683731","https://openalex.org/W2082363371","https://openalex.org/W2083472765","https://openalex.org/W2084076721","https://openalex.org/W2086643735","https://openalex.org/W2089713642","https://openalex.org/W2091294488","https://openalex.org/W2104685489","https://openalex.org/W2105057579","https://openalex.org/W2113341046","https://openalex.org/W2119021947","https://openalex.org/W2121358285","https://openalex.org/W2121792600","https://openalex.org/W2122347714","https://openalex.org/W2122386753","https://openalex.org/W2125650861","https://openalex.org/W2126224335","https://openalex.org/W2137890268","https://openalex.org/W2144475886","https://openalex.org/W2144847502","https://openalex.org/W2145530136","https://openalex.org/W2150722073","https://openalex.org/W2157051245","https://openalex.org/W2157515809","https://openalex.org/W2160413407","https://openalex.org/W2165471414","https://openalex.org/W2232686695","https://openalex.org/W2325735106","https://openalex.org/W2326282712","https://openalex.org/W4234012592","https://openalex.org/W4250620625"],"related_works":["https://openalex.org/W2084076721","https://openalex.org/W2097315772","https://openalex.org/W1979312185","https://openalex.org/W2009398056","https://openalex.org/W2084883948","https://openalex.org/W2746589792","https://openalex.org/W2029804751","https://openalex.org/W2041052826","https://openalex.org/W2157515809","https://openalex.org/W2044771132"],"abstract_inverted_index":{"Depending":[0],"on":[1],"its":[2],"concentration,":[3],"nitric":[4],"oxide":[5],"(NO)":[6],"has":[7],"beneficial":[8],"or":[9,163],"toxic":[10,101],"effects.":[11],"In":[12],"pathological":[13],"conditions,":[14],"NO":[15,58,73,112,138,145,169],"reacts":[16],"with":[17,79,95,129,161],"superoxide":[18],"to":[19,30,67,144,168],"form":[20],"peroxynitrite,":[21],"which":[22,85],"nitrates":[23],"proteins":[24],"forming":[25],"nitrotyrosine":[26],"residues":[27],"(3NY),":[28],"leading":[29],"loss":[31,117],"of":[32,36,83,118,151,195],"protein":[33],"function,":[34],"perturbation":[35],"signal":[37],"transduction,":[38],"and":[39,154],"cell":[40],"death.":[41],"3NY":[42],"immunoreactivity":[43],"is":[44,86,108,124,146],"present":[45,148],"in":[46,90,149],"many":[47],"CNS":[48],"diseases,":[49],"particularly":[50],"multiple":[51,196],"sclerosis.":[52],"Here,":[53],"using":[54],"the":[55,80,100,186,192],"high":[56],"flux":[57],"donor,":[59],"spermine-NONOate,":[60],"we":[61],"report":[62],"that":[63,179,189],"oligodendrocytes":[64,153,174,190],"are":[65,72,191],"resistant":[66,167],"NO,":[68],"while":[69],"motor":[70,91,155,158,181],"neurons":[71,92,159],"sensitive.":[74],"Motor":[75],"neuron":[76],"sensitivity":[77,143],"correlates":[78],"NO-dependent":[81],"formation":[82],"3NY,":[84],"significantly":[87],"more":[88],"pronounced":[89],"when":[93],"compared":[94],"oligodendrocytes,":[96,162],"suggesting":[97],"peroxynitrite":[98,127,134],"as":[99,114,135],"molecule.":[102],"The":[103],"heme-metabolizing":[104],"enzyme,":[105],"heme-oxygenase-1":[106],"(HO1),":[107],"necessary":[109],"for":[110,137],"oligodendrocyte":[111],"resistance,":[113],"demonstrated":[115],"by":[116,126],"resistance":[119],"after":[120],"HO1":[121],"inhibition.":[122],"Resistance":[123],"reinstated":[125],"scavenging":[128],"uric":[130],"acid":[131],"further":[132],"implicating":[133],"responsible":[136],"sensitivity.":[139],"Most":[140],"importantly,":[141],"differential":[142],"also":[147],"cultures":[150],"primary":[152],"neurons.":[156,182],"Finally,":[157],"cocultured":[160],"oligodendrocyte-conditioned":[164],"media,":[165],"become":[166],"toxicity.":[170],"Preliminary":[171],"studies":[172],"suggest":[173],"release":[175],"a":[176],"soluble":[177],"factor":[178],"protects":[180],"Our":[183],"findings":[184],"challenge":[185],"current":[187],"paradigm":[188],"exclusive":[193],"target":[194],"sclerosis":[197],"pathology.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
