{"id":"https://openalex.org/W1975544512","doi":"https://doi.org/10.1073/pnas.79.8.2654","title":"Mouse Lyt-2 antigen: evidence for two heterodimers with a common subunit.","display_name":"Mouse Lyt-2 antigen: evidence for two heterodimers with a common subunit.","publication_year":1982,"publication_date":"1982-04-01","ids":{"openalex":"https://openalex.org/W1975544512","doi":"https://doi.org/10.1073/pnas.79.8.2654","mag":"1975544512","pmid":"https://pubmed.ncbi.nlm.nih.gov/6178108","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/346259"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.79.8.2654","doi":"https://doi.org/10.1073/pnas.79.8.2654","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.79.8.2654","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC346259","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078086926","display_name":"Gregory D. Jay","orcid":"https://orcid.org/0000-0003-1517-8488","observed_orcids":["https://orcid.org/0000-0003-1517-8488"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Jay","raw_affiliation_strings":["Lboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; and","tMemorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"tMemorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000260833","display_name":"Michael A. Palladino","orcid":"https://orcid.org/0000-0002-4687-7612","observed_orcids":["https://orcid.org/0000-0002-4687-7612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Palladino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033280501","display_name":"George Khoury","orcid":"https://orcid.org/0000-0001-8845-9542","observed_orcids":["https://orcid.org/0000-0001-8845-9542"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Khoury","raw_affiliation_strings":["Lboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; and","tMemorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"tMemorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089344430","display_name":"Lloyd J. Old","orcid":"https://orcid.org/0000-0002-2333-7445","observed_orcids":["https://orcid.org/0000-0002-2333-7445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L J Old","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8791,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.90958109,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"8","first_page":"2654","last_page":"2657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-surface-antigens","display_name":"T cell surface antigens","score":0.5600000023841858},{"id":"https://openalex.org/keywords/disulfide-linked-subunits","display_name":"disulfide-linked subunits","score":0.8130000233650208},{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.5929999947547913},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.7490000128746033},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.800464391708374},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.770804762840271},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.6228980422019958},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5449127554893494},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.536111056804657},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.49434614181518555},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.4912671446800232},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.48350122570991516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4806005656719208},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45680636167526245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3684729337692261},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3542172908782959},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08591243624687195},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.059864580631256104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000950","descriptor_name":"Antigens, Ly","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.79.8.2654","doi":"https://doi.org/10.1073/pnas.79.8.2654","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.79.8.2654","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1460071","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC346259","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:346259","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/346259","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6178108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6178108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1982-3504","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1982/2505","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1982","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1460071","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC346259","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1484731058","https://openalex.org/W1565128007","https://openalex.org/W1611472493","https://openalex.org/W1612135387","https://openalex.org/W1632334415","https://openalex.org/W1976766530","https://openalex.org/W2004195826","https://openalex.org/W2012434010","https://openalex.org/W2018289835","https://openalex.org/W2036355264","https://openalex.org/W2040630935","https://openalex.org/W2057108942","https://openalex.org/W2058409289","https://openalex.org/W2070437307","https://openalex.org/W2086613600","https://openalex.org/W2088731565","https://openalex.org/W2092897619","https://openalex.org/W2094228017","https://openalex.org/W2099714459","https://openalex.org/W2101108802","https://openalex.org/W2104490932","https://openalex.org/W2117138187","https://openalex.org/W2139203324","https://openalex.org/W2149814404","https://openalex.org/W2161304120","https://openalex.org/W2421826808","https://openalex.org/W4299419320","https://openalex.org/W4313310568"],"related_works":["https://openalex.org/W1968382704","https://openalex.org/W2415426848","https://openalex.org/W2167744016","https://openalex.org/W2139203324","https://openalex.org/W1964658634","https://openalex.org/W1975801325","https://openalex.org/W2023708977","https://openalex.org/W2066134271","https://openalex.org/W78447580","https://openalex.org/W2104490932"],"abstract_inverted_index":{"Immunoprecipitation":[0],"of":[1,4,18,29,42,54,59,62,101,130,138,155,163,168,174,185,188],"[35S]methionine-labeled":[2],"extracts":[3,137],"BALB/c":[5],"thymocytes":[6],"with":[7,15,72],"mouse":[8],"Lyt-2.2":[9,114],"monoclonal":[10,119],"antibody":[11,120],"yielded":[12],"three":[13,47],"components":[14,158],"subunit":[16,66,77,129],"Mrs":[17,154],"37,000,":[19],"32,000,":[20],"and":[21],"28,000":[22,65,125],"on":[23,122],"NaDodSO4/polyacrylamide":[24,105],"gel":[25,35,106],"in":[26,39,51,89,93,171,182],"the":[27,40,46,52,94,113,118,123,127,151,156,164,172,183],"presence":[28],"a":[30,43,63,104,108],"reducing":[31,44],"agent.":[32],"Two-dimensional":[33],"polyacrylamide":[34],"analysis":[36,97],"revealed":[37],"that,":[38],"absence":[41],"agent,":[45],"polypeptide":[48],"chains":[49],"exist":[50],"form":[53],"two":[55,84],"heterodimers,":[56],"each":[57],"consisting":[58],"one":[60,74,79,186],"molecule":[61],"Mr":[64,75,80,124],"covalently":[67],"associated":[68],"through":[69],"disulfide":[70],"bonds":[71],"either":[73],"37,000":[76],"or":[78],"32,000":[81],"subunit.":[82],"These":[83],"molecular":[85],"structures":[86],"are":[87],"present":[88],"about":[90],"equimolar":[91],"ratios":[92],"immunoprecipitate.":[95],"Immunoautoradiographic":[96],"after":[98],"electrophoretic":[99],"transfer":[100],"proteins":[102],"from":[103,136],"to":[107],"nitrocellulose":[109],"membrane":[110],"indicated":[111],"that":[112,177],"determinant":[115],"detected":[116],"by":[117],"resides":[121],"component,":[126],"common":[128],"both":[131],"heterodimeric":[132],"structures.":[133],"Lyt-2":[134,165],"precipitated":[135],"different":[139],"T-cell":[140,144,189],"growth":[141],"factor-dependent":[142],"cloned":[143],"lines":[145],"also":[146],"showed":[147],"similar":[148],"structures,":[149],"although":[150],"exact":[152],"apparent":[153],"respective":[157],"varied":[159],"somewhat.":[160],"The":[161],"structure":[162],"antigen":[166],"is":[167],"importance,":[169],"particularly":[170],"light":[173],"recent":[175],"suggestions":[176],"it":[178],"may":[179],"be":[180],"involved":[181],"construction":[184],"class":[187],"receptors.":[190]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}