{"id":"https://openalex.org/W1975463863","doi":"https://doi.org/10.1186/s12948-015-0016-x","title":"Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly","display_name":"Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly","publication_year":2015,"publication_date":"2015-04-20","ids":{"openalex":"https://openalex.org/W1975463863","doi":"https://doi.org/10.1186/s12948-015-0016-x","mag":"1975463863","pmid":"https://pubmed.ncbi.nlm.nih.gov/26101468","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4476207"},"language":"en","primary_location":{"id":"doi:10.1186/s12948-015-0016-x","doi":"https://doi.org/10.1186/s12948-015-0016-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12948-015-0016-x","pdf_url":"https://clinicalmolecularallergy.biomedcentral.com/counter/pdf/10.1186/s12948-015-0016-x","source":{"id":"https://openalex.org/S24861470","display_name":"Clinical and Molecular Allergy","issn_l":"1476-7961","issn":["1476-7961"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Molecular Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://clinicalmolecularallergy.biomedcentral.com/counter/pdf/10.1186/s12948-015-0016-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004648556","display_name":"Nicola Scichilone","orcid":"https://orcid.org/0000-0001-6400-6573","observed_orcids":["https://orcid.org/0000-0001-6400-6573"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Nicola Scichilone","raw_affiliation_strings":["Department of Medicine, University of Palermo, via Trabucco 180, 90146 Palermo, Italy","Department of Medicine, University of Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Palermo, via Trabucco 180, 90146 Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Department of Medicine, University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083725831","display_name":"Maria Teresa Ventura","orcid":"https://orcid.org/0000-0002-2637-4583","observed_orcids":["https://orcid.org/0000-0002-2637-4583"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria T Ventura","raw_affiliation_strings":["Interdisciplinary Department of Medicine, Unit of Geriatric Immunoallergology, University of Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Department of Medicine, Unit of Geriatric Immunoallergology, University of Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101502307","display_name":"Matteo Bonini","orcid":"https://orcid.org/0000-0002-3042-0765","observed_orcids":["https://orcid.org/0000-0002-3042-0765"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Bonini","raw_affiliation_strings":["Lung Function Unit, Department of Public Health and Infectious Diseases \"Sapienza\", University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Function Unit, Department of Public Health and Infectious Diseases \"Sapienza\", University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029463785","display_name":"Fulvio Braido","orcid":"https://orcid.org/0000-0003-2460-4709","observed_orcids":["https://orcid.org/0000-0003-2460-4709","https://orcid.org/0000-0002-9836-8959"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fulvio Braido","raw_affiliation_strings":["Respiratory Diseases & Allergy Clinic, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Diseases & Allergy Clinic, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069606284","display_name":"Caterina B. Bucca","orcid":"https://orcid.org/0000-0002-9941-9236","observed_orcids":["https://orcid.org/0000-0002-9941-9236"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Caterina Bucca","raw_affiliation_strings":["Pneumology Unit, Department of Medical Sciences, University of Turin, AOU San Giovanni Battista, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology Unit, Department of Medical Sciences, University of Turin, AOU San Giovanni Battista, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029867716","display_name":"Marco Caminati","orcid":"https://orcid.org/0000-0001-7383-1487","observed_orcids":["https://orcid.org/0000-0001-7383-1487","https://orcid.org/0009-0009-1134-059X"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Caminati","raw_affiliation_strings":["Allergy Unit, Verona University and General Hospital, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy Unit, Verona University and General Hospital, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111668026","display_name":"Stefano Del Giacco","orcid":"https://orcid.org/0000-0002-4517-1749","observed_orcids":["https://orcid.org/0000-0002-4517-1749"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Del Giacco","raw_affiliation_strings":["Department of Medical Sciences \"M. Aresu\", University of Cagliari, Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences \"M. Aresu\", University of Cagliari, Cagliari, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078033835","display_name":"Enrico Marco Heffler","orcid":"https://orcid.org/0000-0002-0492-5663","observed_orcids":["https://orcid.org/0000-0002-0492-5663"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Heffler","raw_affiliation_strings":["Department of Clinical and Experimental Medicine - Respiratory Medicine & Allergy, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine - Respiratory Medicine & Allergy, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021758804","display_name":"Carlo Lombardi","orcid":"https://orcid.org/0000-0002-7120-5877","observed_orcids":["https://orcid.org/0000-0002-7120-5877","https://orcid.org/0000-0002-9960-0510"]},"institutions":[{"id":"https://openalex.org/I4210148231","display_name":"Fondazione Poliambulanza Istituto Ospedaliero","ror":"https://ror.org/03kt3v622","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210148231"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Lombardi","raw_affiliation_strings":["Departmental Unit of Allergology-Clinical Immunology & Pneumology, Fondazione Poliambulanza, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmental Unit of Allergology-Clinical Immunology & Pneumology, Fondazione Poliambulanza, Brescia, Italy","institution_ids":["https://openalex.org/I4210148231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014039023","display_name":"Andrea Matucci","orcid":"https://orcid.org/0000-0002-8713-4161","observed_orcids":["https://orcid.org/0000-0002-8713-4161","https://orcid.org/0000-0002-3499-992X"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Matucci","raw_affiliation_strings":["Centre of Excellence DENOTHE, Dept. of Experimental and Clinical Medicine, Units of Immunoallergology Azienda Ospedaliero-Universitaria Careggi, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Excellence DENOTHE, Dept. of Experimental and Clinical Medicine, Units of Immunoallergology Azienda Ospedaliero-Universitaria Careggi, Florence, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034740825","display_name":"Manlio Milanese","orcid":"https://orcid.org/0000-0001-9626-6230","observed_orcids":["https://orcid.org/0000-0001-9626-6230"]},"institutions":[{"id":"https://openalex.org/I4210149359","display_name":"Azienda Sanitaria Locale N. 2 Savonese","ror":"https://ror.org/04kz5k469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149359"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Manlio Milanese","raw_affiliation_strings":["Struttura Complessa di Pneumologia, ASL2 Savonese, Savona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Struttura Complessa di Pneumologia, ASL2 Savonese, Savona, Italy","institution_ids":["https://openalex.org/I4210149359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054888070","display_name":"Roberto Paganelli","orcid":"https://orcid.org/0000-0003-3467-9317","observed_orcids":["https://orcid.org/0000-0003-3467-9317"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Paganelli","raw_affiliation_strings":["Laboratory of Immunology and Allergy, Department of Medicine and Sciences of Aging, University of G. d'Annunzio, Chieti Scalo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology and Allergy, Department of Medicine and Sciences of Aging, University of G. d'Annunzio, Chieti Scalo, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073839386","display_name":"Giovanni Passalacqua","orcid":"https://orcid.org/0000-0002-5139-3604","observed_orcids":["https://orcid.org/0000-0002-5139-3604"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Passalacqua","raw_affiliation_strings":["Respiratory Diseases & Allergy Clinic, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Diseases & Allergy Clinic, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044096444","display_name":"Vincenzo Patella","orcid":"https://orcid.org/0000-0001-5640-6446","observed_orcids":["https://orcid.org/0000-0001-5640-6446"]},"institutions":[{"id":"https://openalex.org/I4405255019","display_name":"Azienda Sanitaria Locale Salerno","ror":"https://ror.org/02gwsdp44","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405255019"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Patella","raw_affiliation_strings":["Division of Allergy and Clinical Immunology, ASL SALERNO, Hospital of Battipaglia, 84100 Salerno, Italy","Division of Allergy and Clinical Immunology, ASL SALERNO, Hospital of Battipaglia, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Clinical Immunology, ASL SALERNO, Hospital of Battipaglia, 84100 Salerno, Italy","institution_ids":["https://openalex.org/I4405255019"]},{"raw_affiliation_string":"Division of Allergy and Clinical Immunology, ASL SALERNO, Hospital of Battipaglia, Salerno, Italy","institution_ids":["https://openalex.org/I4405255019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009038084","display_name":"Erminia Ridolo","orcid":"https://orcid.org/0000-0003-1439-7902","observed_orcids":["https://orcid.org/0000-0003-1439-7902"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erminia Ridolo","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060292739","display_name":"Giovanni Rolla","orcid":"https://orcid.org/0000-0001-5997-7172","observed_orcids":["https://orcid.org/0000-0001-5997-7172"]},"institutions":[{"id":"https://openalex.org/I4210129188","display_name":"A. O. Ordine Mauriziano di Torino","ror":"https://ror.org/03efxpx82","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210129188"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Rolla","raw_affiliation_strings":["Allergologia e Immunologia Clinica, AO Ordine Mauriziano & University of Torino, Torino, Italy","Allergologia e Immunologia Clinica, AO Ordine Mauriziano and University of Torino, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergologia e Immunologia Clinica, AO Ordine Mauriziano & University of Torino, Torino, Italy","institution_ids":["https://openalex.org/I4210129188","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Allergologia e Immunologia Clinica, AO Ordine Mauriziano and University of Torino, Torino, Italy","institution_ids":["https://openalex.org/I4210129188","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103914063","display_name":"Oliviero Rossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Oliviero Rossi","raw_affiliation_strings":["Units of Immunoallergology Azienda Ospedaliero-Universitaria Careggi, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Units of Immunoallergology Azienda Ospedaliero-Universitaria Careggi, Florence, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078377242","display_name":"Domenico Schiavino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Schiavino","raw_affiliation_strings":["Universit\u00e0 Cattolica del Sacro Cuore, Policlinico A.Gemelli, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e0 Cattolica del Sacro Cuore, Policlinico A.Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037101918","display_name":"Gianenrico Senna","orcid":"https://orcid.org/0000-0003-4172-3216","observed_orcids":["https://orcid.org/0000-0003-4172-3216"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianenrico Senna","raw_affiliation_strings":["Allergy Unit, Verona University and General Hospital, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy Unit, Verona University and General Hospital, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049152611","display_name":"Gundi Steinhilber","orcid":"https://orcid.org/0000-0003-3532-8420","observed_orcids":["https://orcid.org/0000-0003-3532-8420"]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gundi Steinhilber","raw_affiliation_strings":["Division of Pneumology, Spedali Civili di Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pneumology, Spedali Civili di Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I4210103289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004318668","display_name":"Alessandra Vultaggio","orcid":"https://orcid.org/0000-0002-8775-9217","observed_orcids":["https://orcid.org/0000-0002-8775-9217"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Vultaggio","raw_affiliation_strings":["Centre of Excellence DENOTHE, Dept. of Experimental and Clinical Medicine, Units of Immunoallergology Azienda Ospedaliero-Universitaria Careggi, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Excellence DENOTHE, Dept. of Experimental and Clinical Medicine, Units of Immunoallergology Azienda Ospedaliero-Universitaria Careggi, Florence, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030629710","display_name":"Giorgio Walter Canonica","orcid":"https://orcid.org/0000-0001-8467-2557","observed_orcids":["https://orcid.org/0000-0001-8467-2557"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Canonica","raw_affiliation_strings":["Respiratory Diseases & Allergy Clinic, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Diseases & Allergy Clinic, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":19,"corresponding_author_ids":["https://openalex.org/A5004648556"],"corresponding_institution_ids":["https://openalex.org/I900890020"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":5.118,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.95981892,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"7","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/geriatric-asthma","display_name":"geriatric asthma","score":0.8820000290870667},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.7919999957084656},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7900000214576721},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6600000262260437},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9319999814033508},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.8309999704360962},{"id":"https://openalex.org/keywords/underdiagnosis","display_name":"underdiagnosis","score":0.6460000276565552},{"id":"https://openalex.org/keywords/copd-misdiagnosis","display_name":"COPD misdiagnosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.5099999904632568},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/non-pharmacological-treatment","display_name":"non-pharmacological treatment","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9000105857849121},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8655813932418823},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5712726712226868},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5287900567054749},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.528242290019989},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4313175082206726},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.37342411279678345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24822494387626648},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1398170292377472}],"mesh":[],"locations_count":12,"locations":[{"id":"doi:10.1186/s12948-015-0016-x","doi":"https://doi.org/10.1186/s12948-015-0016-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12948-015-0016-x","pdf_url":"https://clinicalmolecularallergy.biomedcentral.com/counter/pdf/10.1186/s12948-015-0016-x","source":{"id":"https://openalex.org/S24861470","display_name":"Clinical and Molecular Allergy","issn_l":"1476-7961","issn":["1476-7961"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Molecular Allergy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3436918","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4476207","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26101468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26101468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and molecular allergy : CMA","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4476207","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4476207/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Mol Allergy","raw_type":"Text"},{"id":"pmh:oai:iris.unito.it:2318/1567831","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1567831","pdf_url":"https://iris.unito.it/bitstream/2318/1567831/1/ELSA.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unica.it:11584/110806","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11584/110806","pdf_url":null,"source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unige.it:11567/844283","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/844283","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unipa.it:10447/209055","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10447/209055","pdf_url":null,"source":{"id":"https://openalex.org/S4377196289","display_name":"IRIS UniPA (University of Palermo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I900890020","host_organization_name":"University of Palermo","host_organization_lineage":["https://openalex.org/I900890020"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1707042","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1707042","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1707047","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1707047","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publicatt.unicatt.it:10807/70337","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10807/70337","pdf_url":null,"source":{"id":"https://openalex.org/S4306400564","display_name":"PubliCatt (Universit\u00e0 Cattolica del Sacro Cuore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.uniba.it:11586/139873","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11586/139873","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12948-015-0016-x","doi":"https://doi.org/10.1186/s12948-015-0016-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12948-015-0016-x","pdf_url":"https://clinicalmolecularallergy.biomedcentral.com/counter/pdf/10.1186/s12948-015-0016-x","source":{"id":"https://openalex.org/S24861470","display_name":"Clinical and Molecular Allergy","issn_l":"1476-7961","issn":["1476-7961"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Molecular Allergy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975463863.pdf","grobid_xml":"https://content.openalex.org/works/W1975463863.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W130169744","https://openalex.org/W387031605","https://openalex.org/W1860355391","https://openalex.org/W1974308284","https://openalex.org/W1976187808","https://openalex.org/W1977665773","https://openalex.org/W1980177766","https://openalex.org/W1981253636","https://openalex.org/W1982564755","https://openalex.org/W1991564084","https://openalex.org/W1994277369","https://openalex.org/W1995545445","https://openalex.org/W1997120806","https://openalex.org/W1998024345","https://openalex.org/W1998605629","https://openalex.org/W1999602107","https://openalex.org/W1999989192","https://openalex.org/W2000099703","https://openalex.org/W2001003469","https://openalex.org/W2005083342","https://openalex.org/W2005838858","https://openalex.org/W2006221229","https://openalex.org/W2008117123","https://openalex.org/W2008918292","https://openalex.org/W2008955505","https://openalex.org/W2009647013","https://openalex.org/W2011807924","https://openalex.org/W2012226794","https://openalex.org/W2016186233","https://openalex.org/W2017283998","https://openalex.org/W2022429437","https://openalex.org/W2023228660","https://openalex.org/W2025111901","https://openalex.org/W2028577578","https://openalex.org/W2030631438","https://openalex.org/W2031529000","https://openalex.org/W2032804627","https://openalex.org/W2034746950","https://openalex.org/W2040566096","https://openalex.org/W2047289094","https://openalex.org/W2049192788","https://openalex.org/W2051791830","https://openalex.org/W2057930810","https://openalex.org/W2059989269","https://openalex.org/W2060391095","https://openalex.org/W2061034377","https://openalex.org/W2062913649","https://openalex.org/W2063150059","https://openalex.org/W2064718369","https://openalex.org/W2065050446","https://openalex.org/W2067029676","https://openalex.org/W2067757232","https://openalex.org/W2073545745","https://openalex.org/W2073941331","https://openalex.org/W2078018113","https://openalex.org/W2079488373","https://openalex.org/W2079684859","https://openalex.org/W2080529320","https://openalex.org/W2081102456","https://openalex.org/W2082524151","https://openalex.org/W2087659881","https://openalex.org/W2090062215","https://openalex.org/W2092406987","https://openalex.org/W2092531447","https://openalex.org/W2094881772","https://openalex.org/W2096930280","https://openalex.org/W2099217132","https://openalex.org/W2105709822","https://openalex.org/W2105838797","https://openalex.org/W2107207387","https://openalex.org/W2108172159","https://openalex.org/W2108337616","https://openalex.org/W2109586110","https://openalex.org/W2112137992","https://openalex.org/W2112166111","https://openalex.org/W2116524083","https://openalex.org/W2118282955","https://openalex.org/W2118791757","https://openalex.org/W2119723202","https://openalex.org/W2120604664","https://openalex.org/W2121192844","https://openalex.org/W2123257822","https://openalex.org/W2125134101","https://openalex.org/W2128577459","https://openalex.org/W2130465252","https://openalex.org/W2132344228","https://openalex.org/W2132719084","https://openalex.org/W2135622170","https://openalex.org/W2137181740","https://openalex.org/W2141404616","https://openalex.org/W2142589482","https://openalex.org/W2143143001","https://openalex.org/W2152531312","https://openalex.org/W2154880808","https://openalex.org/W2155441883","https://openalex.org/W2155939226","https://openalex.org/W2161091193","https://openalex.org/W2162154826","https://openalex.org/W2162816584","https://openalex.org/W2164147349","https://openalex.org/W2164223786","https://openalex.org/W2164600165","https://openalex.org/W2165174834","https://openalex.org/W2182579100","https://openalex.org/W2185186195","https://openalex.org/W2277315718","https://openalex.org/W2325194845","https://openalex.org/W2328345995","https://openalex.org/W2399668678","https://openalex.org/W2412001083","https://openalex.org/W2418431792","https://openalex.org/W2418748824","https://openalex.org/W2467980325","https://openalex.org/W2613829742","https://openalex.org/W2746562707","https://openalex.org/W3035269803","https://openalex.org/W3148692937","https://openalex.org/W4250109354","https://openalex.org/W4291193084","https://openalex.org/W4301867525"],"related_works":["https://openalex.org/W2268089212","https://openalex.org/W2214184926","https://openalex.org/W2073545745","https://openalex.org/W2309809606","https://openalex.org/W7062450838","https://openalex.org/W2077359294","https://openalex.org/W2737288556","https://openalex.org/W2507457290","https://openalex.org/W2516206521","https://openalex.org/W2304195203"],"abstract_inverted_index":{"The":[0,98,130],"prevalence":[1],"of":[2,13,43,62,72,77,84,90,107,119,128,141,164,181,215],"asthma":[3,26,40,47,143,220],"in":[4,31,48,94,111,144,186,218,221],"the":[5,17,32,41,49,70,81,87,91,105,120,126,134,139,145,150,211,222],"most":[6,175],"advanced":[7,165],"ages":[8],"is":[9,51,66],"similar":[10],"to":[11,39,60,69,124,138,200],"that":[12,19],"younger":[14],"ages.":[15,188],"However,":[16],"concept":[18],"older":[20,99],"individuals":[21],"may":[22,122],"suffer":[23],"from":[24],"allergic":[25,92,142,162,219],"has":[27,183,192],"been":[28,184],"largely":[29],"denied":[30],"past,":[33],"and":[34,74,86,116,157,172,205,213],"a":[35],"common":[36],"belief":[37],"attributes":[38],"definition":[42],"\"rare\"":[44],"disease.":[45],"Indeed,":[46],"elderly":[50,223],"often":[52],"underdiagnosed":[53],"or":[54],"diagnosed":[55],"as":[56],"COPD,":[57],"thus":[58],"leading":[59],"undertreatment":[61],"improper":[63],"treatment.":[64],"This":[65],"also":[67,103],"due":[68],"heterogeneity":[71],"clinical":[73,201],"functional":[75,117],"presentations":[76],"geriatric":[78,146],"asthma,":[79],"including":[80],"partial":[82],"loss":[83],"reversibility":[85],"lower":[88],"occurrence":[89],"component":[93],"this":[95],"age":[96,191],"range.":[97],"asthmatic":[100],"patients":[101],"are":[102,177,224],"characterized":[104],"coexistence":[106],"comorbid":[108],"conditions":[109],"that,":[110],"conjunction":[112],"with":[113],"age-associated":[114],"structural":[115],"changes":[118],"lung,":[121],"contribute":[123],"complicate":[125],"management":[127,140],"asthma.":[129],"current":[131,155],"review":[132],"addresses":[133],"main":[135],"issues":[136],"related":[137],"age.":[147],"In":[148,189],"particular,":[149],"paper":[151],"aims":[152],"at":[153],"revising":[154],"pharmacological":[156,159],"non":[158],"treatments":[160],"for":[161,198],"asthmatics":[163],"ages,":[166],"primarily":[167],"focusing":[168],"on":[169],"their":[170],"safety":[171,214],"efficacy,":[173],"although":[174],"behaviors":[176],"an":[178,195],"arbitrary":[179],"extrapolation":[180],"what":[182],"tested":[185],"young":[187],"fact,":[190],"always":[193],"represented":[194],"exclusion":[196],"criterion":[197],"eligibility":[199],"trials.":[202],"Experimental":[203],"studies":[204],"real":[206],"life":[207],"observations":[208],"specifically":[209],"testing":[210],"efficacy":[212],"therapeutic":[216],"approaches":[217],"urgently":[225],"needed.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}