{"id":"https://openalex.org/W1975463767","doi":"https://doi.org/10.1097/00004424-200108000-00002","title":"Physicochemical and Biological Evaluation of P792, a Rapid-Clearance Blood-Pool Agent for Magnetic Resonance Imaging","display_name":"Physicochemical and Biological Evaluation of P792, a Rapid-Clearance Blood-Pool Agent for Magnetic Resonance Imaging","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W1975463767","doi":"https://doi.org/10.1097/00004424-200108000-00002","mag":"1975463767","pmid":"https://pubmed.ncbi.nlm.nih.gov/11500594"},"language":"en","primary_location":{"id":"doi:10.1097/00004424-200108000-00002","doi":"https://doi.org/10.1097/00004424-200108000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004424-200108000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S136338150","display_name":"Investigative Radiology","issn_l":"0020-9996","issn":["0020-9996","1536-0210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Radiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003655871","display_name":"Marc Port","orcid":"https://orcid.org/0000-0001-9870-859X","observed_orcids":["https://orcid.org/0000-0001-9870-859X"]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"MARC PORT","raw_affiliation_strings":["MRI Contrast Agent Research, Guerbet, Roissy, France. portm@guerbet-group.com","From Guerbet, Roissy, France","Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRI Contrast Agent Research, Guerbet, Roissy, France. portm@guerbet-group.com","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"From Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","institution_ids":[]},{"raw_affiliation_string":"Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016040044","display_name":"Claire Corot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"CLAIRE COROT","raw_affiliation_strings":["Guerbet, Roissy, France","From Guerbet, Roissy, France","Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"From Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","institution_ids":[]},{"raw_affiliation_string":"Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033412323","display_name":"Isabelle Raynal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"ISABELLE RAYNAL","raw_affiliation_strings":["Guerbet, Roissy, France","From Guerbet, Roissy, France","Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"From Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","institution_ids":[]},{"raw_affiliation_string":"Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034484376","display_name":"Jean\u2010Marc Id\u00e9e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"JEAN-MARC IDEE","raw_affiliation_strings":["Guerbet, Roissy, France","From Guerbet, Roissy, France","Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"From Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","institution_ids":[]},{"raw_affiliation_string":"Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014787055","display_name":"Anne Dencausse","orcid":"https://orcid.org/0000-0003-4665-0837","observed_orcids":["https://orcid.org/0000-0003-4665-0837"]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"ANNE DENCAUSSE","raw_affiliation_strings":["Guerbet, Roissy, France","From Guerbet, Roissy, France","Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"From Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","institution_ids":[]},{"raw_affiliation_string":"Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076364603","display_name":"Eric Lancelot","orcid":"https://orcid.org/0000-0003-2751-9147","observed_orcids":["https://orcid.org/0000-0003-2751-9147"]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"ERIC LANCELOT","raw_affiliation_strings":["Guerbet, Roissy, France","From Guerbet, Roissy, France","Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"From Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","institution_ids":[]},{"raw_affiliation_string":"Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055760021","display_name":"Dominique S. Meyer","orcid":"https://orcid.org/0000-0001-8673-0511","observed_orcids":["https://orcid.org/0000-0001-8673-0511"]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"DOMINIQUE MEYER","raw_affiliation_strings":["Guerbet, Roissy, France","From Guerbet, Roissy, France","Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"From Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","institution_ids":[]},{"raw_affiliation_string":"Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042176427","display_name":"Bruno Bonnemain","orcid":"https://orcid.org/0000-0002-4383-7826","observed_orcids":["https://orcid.org/0000-0002-4383-7826"]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"BRUNO BONNEMAIN","raw_affiliation_strings":["Guerbet, Roissy, France","From Guerbet, Roissy, France","Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"From Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","institution_ids":[]},{"raw_affiliation_string":"Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045184705","display_name":"JEAN LAUTROU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"JEAN LAUTROU","raw_affiliation_strings":["Guerbet, Roissy, France","From Guerbet, Roissy, France","Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"From Guerbet, Roissy, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"Received February 21, 2001, and accepted for publication, after revision, May 2, 2001","institution_ids":[]},{"raw_affiliation_string":"Reprint requests: Marc Port, MRI Contrast Agent Research, Guerbet, BP 50400, 95943 Roissy CDG Cedex, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003655871"],"corresponding_institution_ids":["https://openalex.org/I120615911"],"apc_list":null,"apc_paid":null,"fwci":4.7962,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.95710705,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"8","first_page":"445","last_page":"454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadolinium-based-contrast-agents","display_name":"gadolinium-based contrast agents","score":0.7059999704360962},{"id":"https://openalex.org/keywords/blood-pool-contrast-agent","display_name":"blood pool contrast agent","score":0.7789999842643738},{"id":"https://openalex.org/keywords/r1-relaxivity","display_name":"T1 relaxivity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9819999933242798},{"id":"https://openalex.org/keywords/glomerular-filtration","display_name":"glomerular filtration","score":0.8690000176429749},{"id":"https://openalex.org/keywords/renal-safety","display_name":"renal safety","score":0.722000002861023},{"id":"https://openalex.org/keywords/hemodynamic-safety","display_name":"hemodynamic safety","score":0.9539999961853027},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.8989999890327454},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.546999990940094},{"id":"https://openalex.org/keywords/gd-dota","display_name":"Gd-DOTA","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.9240899085998535},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8235876560211182},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6582962870597839},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.5845465660095215},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5398942232131958},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5213688015937805},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.46446579694747925},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.43644657731056213},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.43406862020492554},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28099408745765686},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2222723662853241},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.21505260467529297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1443043053150177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11453059315681458},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007975","descriptor_name":"Leukotriene B4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004424-200108000-00002","doi":"https://doi.org/10.1097/00004424-200108000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004424-200108000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S136338150","display_name":"Investigative Radiology","issn_l":"0020-9996","issn":["0020-9996","1536-0210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Radiology","raw_type":"journal-article"},{"id":"pmid:11500594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11500594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative radiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1965759929","https://openalex.org/W1978673416","https://openalex.org/W1991214552","https://openalex.org/W1999902399","https://openalex.org/W2000718399","https://openalex.org/W2002972210","https://openalex.org/W2005444217","https://openalex.org/W2008517160","https://openalex.org/W2014147851","https://openalex.org/W2017814526","https://openalex.org/W2018760263","https://openalex.org/W2022309796","https://openalex.org/W2022977216","https://openalex.org/W2033503179","https://openalex.org/W2042127358","https://openalex.org/W2043638187","https://openalex.org/W2043715270","https://openalex.org/W2044957933","https://openalex.org/W2045243571","https://openalex.org/W2049432886","https://openalex.org/W2052825225","https://openalex.org/W2055876104","https://openalex.org/W2055892134","https://openalex.org/W2061334822","https://openalex.org/W2061493426","https://openalex.org/W2069882518","https://openalex.org/W2070881094","https://openalex.org/W2074507898","https://openalex.org/W2079256860","https://openalex.org/W2083366042","https://openalex.org/W2086188919","https://openalex.org/W2088746152","https://openalex.org/W2106194279","https://openalex.org/W2107108336","https://openalex.org/W2107474705","https://openalex.org/W2159207181","https://openalex.org/W2161239029","https://openalex.org/W2326402510","https://openalex.org/W2330618793","https://openalex.org/W2334412386","https://openalex.org/W4229568509","https://openalex.org/W4244327785"],"related_works":["https://openalex.org/W2327389288","https://openalex.org/W2049432886","https://openalex.org/W1973171895","https://openalex.org/W7133402606","https://openalex.org/W7074101818","https://openalex.org/W2161901238","https://openalex.org/W2327936862","https://openalex.org/W2334412386","https://openalex.org/W2107474705","https://openalex.org/W1999902399"],"abstract_inverted_index":{"RATIONALE":[0],"AND":[1],"OBJECTIVES:":[2],"To":[3],"summarize":[4],"the":[5,55,105,126,171,235],"physicochemical":[6],"characterization,":[7],"pharmacokinetic":[8,61,134,208],"behavior,":[9],"and":[10,39,62,84,88,104,135,154,163,209,228],"biological":[11],"evaluation":[12],"of":[13,25,33,54,99,108,125,142,170,192,216,237],"P792,":[14],"a":[15,143,201,217],"new":[16],"monogadolinated":[17],"MRI":[18],"blood-pool":[19,145,219],"agent.":[20,220],"METHODS:":[21],"The":[22,29,52,60,96,123,133,190,207],"molecular":[23],"modeling":[24],"P792":[26,34,100,147,193,238],"was":[27,58,78,183],"described.":[28],"r1":[30,106],"relaxivity":[31,107,191],"properties":[32],"were":[35,65,92],"measured":[36],"in":[37,67,71,82,85,129,185,239],"water":[38],"4%":[40],"human":[41],"serum":[42],"albumin":[43],"at":[44,120,194],"different":[45],"magnetic":[46],"fields":[47],"(20,":[48],"40,":[49],"60":[50,121],"MHz).":[51],"stability":[53,124],"gadolinium":[56,127],"complex":[57,128,203],"assessed.":[59],"biodistribution":[63,136,210],"profiles":[64,137,211],"studied":[66],"rabbits.":[68],"Renal":[69,162],"tolerance":[70],"dehydrated":[72],"rats":[73,83],"undergoing":[74],"selective":[75],"intrarenal":[76],"injection":[77],"evaluated.":[79],"Hemodynamic":[80],"safety":[81,165,223],"vitro":[86],"histamine":[87,178],"leukotriene":[89,180],"B4":[90,181],"release":[91,182],"also":[93],"tested.":[94],"RESULTS:":[95],"mean":[97],"diameter":[98],"is":[101,113,131,148,160,166,197,225],"50.5":[102],"A":[103],"this":[109],"monogadolinium":[110,202],"contrast":[111],"agent":[112,173],"29":[114],"L":[115],"x":[116,118],"mmol(-1)":[117],"s(-1)":[119],"MHz.":[122],"transmetallation":[130],"excellent.":[132],"are":[138,212,231],"consistent":[139,213],"with":[140,214],"that":[141,169],"rapid-clearance":[144,218],"agent:":[146],"mainly":[149],"excreted":[150],"by":[151],"glomerular":[152],"filtration,":[153],"its":[155],"diffusion":[156],"across":[157],"normal":[158],"endothelium":[159],"limited.":[161],"hemodynamic":[164],"comparable":[167],"to":[168,233],"nonspecific":[172],"gadolinium-tetraazacyclododecane":[174],"tetraacetic":[175],"acid.":[176],"No":[177],"or":[179],"found":[184],"RBL-2H3":[186],"isolated":[187],"mastocytes.":[188],"CONCLUSIONS:":[189],"clinical":[195,229],"field":[196],"very":[198],"high":[199],"for":[200],"without":[204],"protein":[205],"binding.":[206],"those":[215],"Its":[221],"initial":[222],"profile":[224],"satisfactory.":[226],"Experimental":[227],"studies":[230],"underway":[232],"confirm":[234],"potential":[236],"MRI.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}