{"id":"https://openalex.org/W1975401441","doi":"https://doi.org/10.1523/jneurosci.6130-10.2011","title":"Multiplicative Dynamics Underlie the Emergence of the Log-Normal Distribution of Spine Sizes in the Neocortex In Vivo","display_name":"Multiplicative Dynamics Underlie the Emergence of the Log-Normal Distribution of Spine Sizes in the Neocortex In Vivo","publication_year":2011,"publication_date":"2011-06-29","ids":{"openalex":"https://openalex.org/W1975401441","doi":"https://doi.org/10.1523/jneurosci.6130-10.2011","mag":"1975401441","pmid":"https://pubmed.ncbi.nlm.nih.gov/21715613","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6623170"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.6130-10.2011","doi":"https://doi.org/10.1523/jneurosci.6130-10.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.6130-10.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/26/9481.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jneurosci.org/content/jneuro/31/26/9481.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074945649","display_name":"Yonatan Loewenstein","orcid":"https://orcid.org/0000-0003-2577-2317","observed_orcids":["https://orcid.org/0000-0003-2577-2317"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Y. Loewenstein","raw_affiliation_strings":["Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Interdisciplinary Center for Neural Computation and Center for Study of Rationality, Hebrew University, Jerusalem 91904, Israel. yonatan@huji.ac.il","Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Interdisciplinary Center for Neural Computation and Center for Study of Rationality, Hebrew University, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Interdisciplinary Center for Neural Computation and Center for Study of Rationality, Hebrew University, Jerusalem 91904, Israel. yonatan@huji.ac.il","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Interdisciplinary Center for Neural Computation and Center for Study of Rationality, Hebrew University, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080059007","display_name":"Antanas Kuras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195525897","display_name":"Research Institute of Molecular Pathology","ror":"https://ror.org/02c5jsm26","country_code":"AT","type":"facility","lineage":["https://openalex.org/I195525897"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Kuras","raw_affiliation_strings":["IMP-Research Institute of Molecular Pathology, Vienna 1030, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMP-Research Institute of Molecular Pathology, Vienna 1030, Austria","institution_ids":["https://openalex.org/I195525897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088926594","display_name":"Simon Rumpel","orcid":"https://orcid.org/0000-0001-7186-148X","observed_orcids":["https://orcid.org/0000-0001-7186-148X"]},"institutions":[{"id":"https://openalex.org/I195525897","display_name":"Research Institute of Molecular Pathology","ror":"https://ror.org/02c5jsm26","country_code":"AT","type":"facility","lineage":["https://openalex.org/I195525897"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"S. Rumpel","raw_affiliation_strings":["IMP-Research Institute of Molecular Pathology, Vienna 1030, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMP-Research Institute of Molecular Pathology, Vienna 1030, Austria","institution_ids":["https://openalex.org/I195525897"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9171,"has_fulltext":true,"cited_by_count":259,"citation_normalized_percentile":{"value":0.94530813,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"31","issue":"26","first_page":"9481","last_page":"9488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9290000200271606},{"id":"https://openalex.org/keywords/lognormal-distribution","display_name":"lognormal distribution","score":0.9120000004768372},{"id":"https://openalex.org/keywords/synaptic-strength","display_name":"synaptic efficacy","score":0.746999979019165},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/auditory-cortex","display_name":"auditory cortex","score":0.7059999704360962},{"id":"https://openalex.org/keywords/neocortex","display_name":"neocortex","score":0.8360000252723694},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.5860000252723694},{"id":"https://openalex.org/keywords/stationary-distribution","display_name":"stationary distribution","score":0.5389999747276306},{"id":"https://openalex.org/keywords/phenomenological-model","display_name":"phenomenological model","score":0.6809999942779541},{"id":"https://openalex.org/keywords/excitatory-synapses","display_name":"excitatory synapses","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.8691403269767761},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7417954802513123},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5573322176933289},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.48115074634552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4639195203781128},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.46128007769584656},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.08613058924674988},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0838521420955658},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001303","descriptor_name":"Auditory Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.6130-10.2011","doi":"https://doi.org/10.1523/jneurosci.6130-10.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.6130-10.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/26/9481.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6623170","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6623170","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:21715613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21715613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.6130-10.2011","doi":"https://doi.org/10.1523/jneurosci.6130-10.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.6130-10.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/26/9481.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6945803473","display_name":null,"funder_award_id":"868/08","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320320033","display_name":"Gatsby Charitable Foundation","ror":"https://ror.org/0290hax27"},{"id":"https://openalex.org/F4320320947","display_name":"German-Israeli Foundation for Scientific Research and Development","ror":"https://ror.org/00tntzp09"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975401441.pdf","grobid_xml":"https://content.openalex.org/works/W1975401441.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1486852018","https://openalex.org/W1512746852","https://openalex.org/W1514853588","https://openalex.org/W1798313689","https://openalex.org/W1966155655","https://openalex.org/W1976485053","https://openalex.org/W1976549989","https://openalex.org/W1976738367","https://openalex.org/W1976958941","https://openalex.org/W1977450749","https://openalex.org/W1979019425","https://openalex.org/W1983553517","https://openalex.org/W1984465702","https://openalex.org/W1985392528","https://openalex.org/W1992156523","https://openalex.org/W2000217522","https://openalex.org/W2001528712","https://openalex.org/W2008284899","https://openalex.org/W2038511109","https://openalex.org/W2042909152","https://openalex.org/W2058352914","https://openalex.org/W2063812162","https://openalex.org/W2074623278","https://openalex.org/W2080351494","https://openalex.org/W2083863715","https://openalex.org/W2087824537","https://openalex.org/W2088446997","https://openalex.org/W2088947792","https://openalex.org/W2090043895","https://openalex.org/W2102787760","https://openalex.org/W2103423972","https://openalex.org/W2113273079","https://openalex.org/W2117664079","https://openalex.org/W2118359066","https://openalex.org/W2121035876","https://openalex.org/W2123820663","https://openalex.org/W2127810309","https://openalex.org/W2128084896","https://openalex.org/W2128378732","https://openalex.org/W2136830964","https://openalex.org/W2139421798","https://openalex.org/W2145255740","https://openalex.org/W2151251384","https://openalex.org/W2153201079","https://openalex.org/W2153564253","https://openalex.org/W2160361560","https://openalex.org/W2162407586","https://openalex.org/W2170159961","https://openalex.org/W2171612971"],"related_works":["https://openalex.org/W4385476565","https://openalex.org/W2118359066","https://openalex.org/W2810212582","https://openalex.org/W7126236895","https://openalex.org/W2324125107","https://openalex.org/W7100318115","https://openalex.org/W6903495197","https://openalex.org/W6907750890","https://openalex.org/W2088947792","https://openalex.org/W2897319680"],"abstract_inverted_index":{"What":[0],"fundamental":[1],"properties":[2],"of":[3,14,30,44,46,52,66,71,83,86,120,130,142,160,176,197],"synaptic":[4,15,31,143,191,198],"connectivity":[5],"in":[6,33,48,54,74,106,122,137],"the":[7,11,24,27,34,49,64,68,75,80,118,128,131,157,188,194],"neocortex":[8],"stem":[9],"from":[10,113],"ongoing":[12,158],"dynamics":[13,65,135,159,192],"changes?":[16],"In":[17],"this":[18,38],"study,":[19],"we":[20,40,154],"seek":[21],"to":[22,61,115,127,183],"find":[23],"rules":[25],"shaping":[26],"stationary":[28,81,195],"distribution":[29,82,196],"efficacies":[32],"cortex.":[35],"To":[36],"address":[37],"question,":[39],"combined":[41],"chronic":[42],"imaging":[43],"hundreds":[45],"spines":[47,102],"auditory":[50],"cortex":[51],"mice":[53],"vivo":[55],"over":[56],"weeks":[57],"with":[58,139],"modeling":[59],"techniques":[60],"quantitatively":[62],"study":[63],"spines,":[67],"morphological":[69],"correlates":[70],"excitatory":[72],"synapses":[73],"neocortex.":[76],"We":[77,98],"found":[78],"that":[79,101,111,156,171],"spine":[84,123,161],"sizes":[85,108,124,162],"individual":[87],"neurons":[88],"can":[89,163],"be":[90,164],"exceptionally":[91],"well":[92],"described":[93],"by":[94,166],"a":[95,167,184],"log-normal":[96,185],"function.":[97],"furthermore":[99],"show":[100,155],"exhibit":[103],"substantial":[104],"volatility":[105],"their":[107],"at":[109,173],"timescales":[110,175],"range":[112],"days":[114,177],"months.":[116,179],"Interestingly,":[117],"magnitude":[119],"changes":[121],"is":[125],"proportional":[126],"size":[129],"spine.":[132],"Such":[133],"multiplicative":[134],"are":[136],"contrast":[138],"conventional":[140],"models":[141],"plasticity,":[144],"learning,":[145],"and":[146,178,193],"memory,":[147],"which":[148],"typically":[149],"assume":[150],"additive":[151],"dynamics.":[152],"Moreover,":[153],"captured":[165],"simple":[168],"phenomenological":[169],"model":[170,181],"operates":[172],"two":[174],"This":[180],"converges":[182],"distribution,":[186],"bridging":[187],"gap":[189],"between":[190],"efficacies.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
