{"id":"https://openalex.org/W197537679","doi":null,"title":"Atherosclerosis as disease of redox-sensitive genes.","display_name":"Atherosclerosis as disease of redox-sensitive genes.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W197537679","mag":"197537679","pmid":"https://pubmed.ncbi.nlm.nih.gov/9601133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2194335"},"language":"en","primary_location":{"id":"pmid:9601133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9601133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Clinical and Climatological Association","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2194335/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109723407","display_name":"RONALD W. ALEXANDER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R W Alexander","raw_affiliation_strings":["Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109723407"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":0.3286,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.4224924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"109","issue":null,"first_page":"129","last_page":"45; discussion 145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.29980000853538513,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9430000185966492},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8619999885559082},{"id":"https://openalex.org/keywords/proinflammatory-gene-expression","display_name":"pro-inflammatory gene expression","score":0.8389999866485596},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.878000020980835},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.996999979019165},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9950000047683716},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7806706428527832},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7654752135276794},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7184746265411377},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5845653414726257},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5553949475288391},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5068073868751526},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4565720856189728},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.44619306921958923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44364869594573975},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41605454683303833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3551102578639984},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2954891622066498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18615937232971191},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17293396592140198},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.146612286567688}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9601133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9601133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Clinical and Climatological Association","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2194335","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2194335/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Clin Climatol Assoc","raw_type":"Text"},{"id":"mag:197537679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9601133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2194335","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2194335/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Clin Climatol Assoc","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1506569093","https://openalex.org/W1535615765","https://openalex.org/W1568529372","https://openalex.org/W1572011530","https://openalex.org/W1857052429","https://openalex.org/W1902029503","https://openalex.org/W1976555160","https://openalex.org/W1994164919","https://openalex.org/W2032319088","https://openalex.org/W2050795431","https://openalex.org/W2054194475","https://openalex.org/W2080480505","https://openalex.org/W2083217753","https://openalex.org/W2093250775","https://openalex.org/W2093664978","https://openalex.org/W2096292525","https://openalex.org/W2099112973","https://openalex.org/W2104573407","https://openalex.org/W2106319388","https://openalex.org/W2107919301","https://openalex.org/W2113441121","https://openalex.org/W2114253742","https://openalex.org/W2126524259","https://openalex.org/W2135633069","https://openalex.org/W2137570167","https://openalex.org/W2138928713","https://openalex.org/W2140337240","https://openalex.org/W2145357314","https://openalex.org/W2159567970","https://openalex.org/W2162010936","https://openalex.org/W2169182236","https://openalex.org/W2265277925","https://openalex.org/W2335161036","https://openalex.org/W4244397698"],"related_works":["https://openalex.org/W135472607","https://openalex.org/W4250631417","https://openalex.org/W2755249976","https://openalex.org/W4233530848","https://openalex.org/W2590331075","https://openalex.org/W2145410445","https://openalex.org/W4251490776","https://openalex.org/W2952075434","https://openalex.org/W2029314163","https://openalex.org/W2418479876"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1,127],"provides":[2,107],"a":[3,38,67],"compelling":[4],"case":[5],"that":[6,24,43,86,128],"one":[7,63],"of":[8,17,29,37,40,59,66,71,105,113,119],"the":[9,15,25,35,57,72,80,103,108,111,117,120],"major":[10],"pathophysiologic":[11],"mechanisms":[12],"involved":[13],"in":[14,54,75],"pathogenesis":[16,104],"atherosclerosis":[18,76,106],"is":[19,34,61],"enhanced":[20],"oxidative":[21],"stress":[22],"and":[23,89],"most":[26],"important":[27,64],"manifestation":[28],"this":[30,55],"altered":[31],"redox":[32],"state":[33],"modulation":[36],"set(s)":[39],"proinflammatory":[41,99],"genes":[42,100],"are":[44],"regulated":[45],"directly":[46],"or":[47],"indirectly":[48],"by":[49],"reactive":[50],"oxygen":[51],"species.":[52],"Viewed":[53],"perspective":[56],"oxidation":[58],"LDL":[60],"but":[62],"consequence":[65],"generalized":[68],"metabolic":[69],"abnormality":[70],"arterial":[73],"wall":[74],"rather":[77],"than":[78],"being":[79],"core":[81],"pathophysiological":[82],"feature.":[83],"The":[84],"fact":[85],"hypercholesterolemia,":[87],"hypertension,":[88],"AGEs":[90],"related":[91],"to":[92],"diabetes":[93],"mellitus":[94],"all":[95],"activate":[96],"similar":[97],"redox-sensitive":[98],"associated":[101],"with":[102],"potential":[109],"for":[110],"development":[112],"unifying":[114],"concepts":[115,123],"concerning":[116],"etiology":[118],"disease.":[121],"These":[122],"also":[124],"provide":[125],"additional":[126],"antioxidants":[129],"may":[130],"be":[131],"potentially":[132],"attractive":[133],"therapeutic":[134],"agents.":[135]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}