{"id":"https://openalex.org/W1975340596","doi":"https://doi.org/10.1006/taap.2001.9192","title":"Mechanism of Urinary Tract Crystal Formation Following Biphenyl Treatment","display_name":"Mechanism of Urinary Tract Crystal Formation Following Biphenyl Treatment","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W1975340596","doi":"https://doi.org/10.1006/taap.2001.9192","mag":"1975340596","pmid":"https://pubmed.ncbi.nlm.nih.gov/11446827"},"language":"en","primary_location":{"id":"doi:10.1006/taap.2001.9192","doi":"https://doi.org/10.1006/taap.2001.9192","is_oa":false,"landing_page_url":"https://doi.org/10.1006/taap.2001.9192","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108759743","display_name":"Makoto Ohnishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I4210095161","display_name":"Japan Industrial Safety and Health Association","ror":"https://ror.org/00jtmm480","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210095161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Ohnishi","raw_affiliation_strings":["Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan. monishi@jisha.or.jp","Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, 1-3 Shinjuku-ku, Tokyo, 162-8601, Japan","Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan. monishi@jisha.or.jp","institution_ids":["https://openalex.org/I4210095161"]},{"raw_affiliation_string":"Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, 1-3 Shinjuku-ku, Tokyo, 162-8601, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan","institution_ids":["https://openalex.org/I4210095161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027197058","display_name":"Hirofumi Yajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Yajima","raw_affiliation_strings":["Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, 1-3 Shinjuku-ku, Tokyo, 162-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, 1-3 Shinjuku-ku, Tokyo, 162-8601, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088539065","display_name":"Tetsuya Takeuchi","orcid":"https://orcid.org/0000-0001-6683-1673","observed_orcids":["https://orcid.org/0000-0001-6683-1673","https://orcid.org/0000-0002-2378-2610"]},"institutions":[{"id":"https://openalex.org/I4210095161","display_name":"Japan Industrial Safety and Health Association","ror":"https://ror.org/00jtmm480","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210095161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Takeuchi","raw_affiliation_strings":["Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan","institution_ids":["https://openalex.org/I4210095161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088097075","display_name":"Misae Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095161","display_name":"Japan Industrial Safety and Health Association","ror":"https://ror.org/00jtmm480","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210095161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misae Saito","raw_affiliation_strings":["Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan","institution_ids":["https://openalex.org/I4210095161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071836414","display_name":"Kazunori Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095161","display_name":"Japan Industrial Safety and Health Association","ror":"https://ror.org/00jtmm480","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210095161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Yamazaki","raw_affiliation_strings":["Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan","institution_ids":["https://openalex.org/I4210095161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110758454","display_name":"Tatsuya Kasai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095161","display_name":"Japan Industrial Safety and Health Association","ror":"https://ror.org/00jtmm480","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210095161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Kasai","raw_affiliation_strings":["Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan","institution_ids":["https://openalex.org/I4210095161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066571069","display_name":"Kasuke Nagano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095161","display_name":"Japan Industrial Safety and Health Association","ror":"https://ror.org/00jtmm480","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210095161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kasuke Nagano","raw_affiliation_strings":["Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan","institution_ids":["https://openalex.org/I4210095161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110416754","display_name":"Seigo Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095161","display_name":"Japan Industrial Safety and Health Association","ror":"https://ror.org/00jtmm480","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210095161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seigo Yamamoto","raw_affiliation_strings":["Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan","institution_ids":["https://openalex.org/I4210095161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109163549","display_name":"Taijiro Matsushima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095161","display_name":"Japan Industrial Safety and Health Association","ror":"https://ror.org/00jtmm480","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210095161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taijiro Matsushima","raw_affiliation_strings":["Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano-shi, Kanagawa, 257-0015, Japan","institution_ids":["https://openalex.org/I4210095161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111898824","display_name":"Tadahiro Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadahiro Ishii","raw_affiliation_strings":["Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, 1-3 Shinjuku-ku, Tokyo, 162-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, 1-3 Shinjuku-ku, Tokyo, 162-8601, Japan","institution_ids":["https://openalex.org/I161296585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.3619,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.55470683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"174","issue":"2","first_page":"122","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5199999809265137,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5199999809265137,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.2442999929189682,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biphenyl","display_name":"biphenyl","score":0.9620000123977661},{"id":"https://openalex.org/keywords/potassium-salts","display_name":"potassium salts","score":0.5130000114440918},{"id":"https://openalex.org/keywords/potassium-bicarbonate","display_name":"potassium bicarbonate","score":0.6890000104904175},{"id":"https://openalex.org/keywords/urine-ph","display_name":"urine pH","score":0.4399999976158142},{"id":"https://openalex.org/keywords/crystal-solubility","display_name":"crystal solubility","score":0.7099999785423279},{"id":"https://openalex.org/keywords/ureteral-obstruction","display_name":"ureteral obstruction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydronephrosis","display_name":"hydronephrosis","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.8437137603759766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6615138649940491},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.6508292555809021},{"id":"https://openalex.org/C2780591471","wikidata":"https://www.wikidata.org/wiki/Q410915","display_name":"Biphenyl","level":2,"score":0.6172274351119995},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.59989994764328},{"id":"https://openalex.org/C2781040948","wikidata":"https://www.wikidata.org/wiki/Q730877","display_name":"Hydronephrosis","level":3,"score":0.4548344016075134},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.38461530208587646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35757410526275635},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.347310334444046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23817431926727295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16748389601707458},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09234863519668579}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014513","descriptor_name":"Ureter","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014513","descriptor_name":"Ureter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014551","descriptor_name":"Urinary Tract","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014551","descriptor_name":"Urinary Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/taap.2001.9192","doi":"https://doi.org/10.1006/taap.2001.9192","is_oa":false,"landing_page_url":"https://doi.org/10.1006/taap.2001.9192","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:11446827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11446827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1864560367","https://openalex.org/W1905622915","https://openalex.org/W1978837197","https://openalex.org/W1986837154","https://openalex.org/W1997184526","https://openalex.org/W1998030924","https://openalex.org/W1998600050","https://openalex.org/W2009497691","https://openalex.org/W2015086590","https://openalex.org/W2017009056","https://openalex.org/W2021103007","https://openalex.org/W2029770935","https://openalex.org/W2031036294","https://openalex.org/W2033497154","https://openalex.org/W2037140399","https://openalex.org/W2055383377","https://openalex.org/W2071826996","https://openalex.org/W2107736912","https://openalex.org/W2170834657","https://openalex.org/W2272757539","https://openalex.org/W2324816908","https://openalex.org/W2334294553","https://openalex.org/W6638903432"],"related_works":["https://openalex.org/W1998600050","https://openalex.org/W2170772961","https://openalex.org/W2042146101","https://openalex.org/W2031914805","https://openalex.org/W6988626233","https://openalex.org/W2011095435","https://openalex.org/W2039489294","https://openalex.org/W2007408599","https://openalex.org/W1973164609","https://openalex.org/W3046941463"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}