{"id":"https://openalex.org/W1975258397","doi":"https://doi.org/10.1172/jci114097","title":"Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries.","display_name":"Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries.","publication_year":1989,"publication_date":"1989-06-01","ids":{"openalex":"https://openalex.org/W1975258397","doi":"https://doi.org/10.1172/jci114097","mag":"1975258397","pmid":"https://pubmed.ncbi.nlm.nih.gov/2542376","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/303911"},"language":"en","primary_location":{"id":"doi:10.1172/jci114097","doi":"https://doi.org/10.1172/jci114097","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114097","pdf_url":"http://www.jci.org/articles/view/114097/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/114097/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113482932","display_name":"J\ufffdrgen Merke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Merke","raw_affiliation_strings":["Department of Internal Medicine, University of Heidelberg, Federal Republic of Germany","Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Heidelberg, Federal Republic of Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075649665","display_name":"Petra Milde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P Milde","raw_affiliation_strings":["Departments of*Internal Medicine, Immunology, and \u00a7Pharmacology , University ofHeidelberg , Federal Republic ofGermany; and I'Department ofBiochemistry ,","Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of*Internal Medicine, Immunology, and \u00a7Pharmacology , University ofHeidelberg , Federal Republic ofGermany; and I'Department ofBiochemistry ,","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107413067","display_name":"Sabina Lewicka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"S Lewicka","raw_affiliation_strings":["Dr. W. Sorg (German Cancer Research Center , Heidelberg , FRG)","University ofArizona , Tucson , Arizona 85724","Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. W. Sorg (German Cancer Research Center , Heidelberg , FRG)","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"University ofArizona , Tucson , Arizona 85724","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005850493","display_name":"Ulrike H\u00fcgel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U H\u00fcgel","raw_affiliation_strings":["Departments of*Internal Medicine, Immunology, and \u00a7Pharmacology , University ofHeidelberg , Federal Republic ofGermany; and I'Department ofBiochemistry ,","Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of*Internal Medicine, Immunology, and \u00a7Pharmacology , University ofHeidelberg , Federal Republic ofGermany; and I'Department ofBiochemistry ,","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008899290","display_name":"G\u00fcnter Klaus","orcid":"https://orcid.org/0000-0001-9453-4326","observed_orcids":["https://orcid.org/0000-0001-9453-4326"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Klaus","raw_affiliation_strings":["Departments of*Internal Medicine, Immunology, and \u00a7Pharmacology , University ofHeidelberg , Federal Republic ofGermany; and I'Department ofBiochemistry ,","Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of*Internal Medicine, Immunology, and \u00a7Pharmacology , University ofHeidelberg , Federal Republic ofGermany; and I'Department ofBiochemistry ,","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010352902","display_name":"David J. Mangelsdorf","orcid":"https://orcid.org/0000-0002-4355-0796","observed_orcids":["https://orcid.org/0000-0002-4355-0796"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"D J Mangelsdorf","raw_affiliation_strings":["University ofArizona , Tucson , Arizona 85724","Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University ofArizona , Tucson , Arizona 85724","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064286100","display_name":"Mark R. Haussler","orcid":"https://orcid.org/0000-0002-7097-1801","observed_orcids":["https://orcid.org/0000-0002-7097-1801"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"M R Haussler","raw_affiliation_strings":["University ofArizona , Tucson , Arizona 85724","Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University ofArizona , Tucson , Arizona 85724","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032733265","display_name":"Ernst Wilhard Rauterberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"E W Rauterberg","raw_affiliation_strings":["University ofArizona , Tucson , Arizona 85724","Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University ofArizona , Tucson , Arizona 85724","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111646516","display_name":"Eberhard Ritz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Ritz","raw_affiliation_strings":["Department of In- ternal Medicine , University of Heidelberg , Bergheimer Strasse 58 , D-6900 Heidelberg , Federal Republic of Germany","Departments of*Internal Medicine, Immunology, and \u00a7Pharmacology , University ofHeidelberg , Federal Republic ofGermany; and I'Department ofBiochemistry ,","Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of In- ternal Medicine , University of Heidelberg , Bergheimer Strasse 58 , D-6900 Heidelberg , Federal Republic of Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Departments of*Internal Medicine, Immunology, and \u00a7Pharmacology , University ofHeidelberg , Federal Republic ofGermany; and I'Department ofBiochemistry ,","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":4.9273,"has_fulltext":true,"cited_by_count":342,"citation_normalized_percentile":{"value":0.95419038,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"83","issue":"6","first_page":"1903","last_page":"1915"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cyp27b1","display_name":"CYP27B1","score":0.8519999980926514},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bovine-aortic-endothelial-cells","display_name":"bovine aortic endothelial cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8569999933242798},{"id":"https://openalex.org/keywords/sphingosine","display_name":"sphingosine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5619999766349792},{"id":"https://openalex.org/keywords/autocrine-loop","display_name":"autocrine loop","score":0.6949999928474426},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d3","display_name":"25-hydroxyvitamin D3","score":0.8519999980926514},{"id":"https://openalex.org/keywords/skin-capillaries","display_name":"skin capillaries","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.7806018590927124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.597509503364563},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5922244787216187},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.46541714668273926},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.450503408908844},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4187988042831421},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.41503986716270447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4053473472595215},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3897255063056946},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37600404024124146},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3694397211074829},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.32633036375045776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2975732088088989},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.08275073766708374},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002112","descriptor_name":"Calcifediol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002112","descriptor_name":"Calcifediol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018167","descriptor_name":"Receptors, Calcitriol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci114097","doi":"https://doi.org/10.1172/jci114097","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114097","pdf_url":"http://www.jci.org/articles/view/114097/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:2542376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2542376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:303911","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC303911/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci114097","doi":"https://doi.org/10.1172/jci114097","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114097","pdf_url":"http://www.jci.org/articles/view/114097/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6636000275611877,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975258397.pdf","grobid_xml":"https://content.openalex.org/works/W1975258397.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W103568847","https://openalex.org/W173401421","https://openalex.org/W1490687264","https://openalex.org/W1520833254","https://openalex.org/W1523493483","https://openalex.org/W1524495054","https://openalex.org/W1557149681","https://openalex.org/W1582284471","https://openalex.org/W1843713741","https://openalex.org/W1963730604","https://openalex.org/W1964839077","https://openalex.org/W1965142759","https://openalex.org/W1975173778","https://openalex.org/W1984489053","https://openalex.org/W1992847499","https://openalex.org/W1996475346","https://openalex.org/W1996572911","https://openalex.org/W1998446559","https://openalex.org/W2001926583","https://openalex.org/W2003575314","https://openalex.org/W2007331929","https://openalex.org/W2012963050","https://openalex.org/W2018108516","https://openalex.org/W2020719528","https://openalex.org/W2022196977","https://openalex.org/W2033431142","https://openalex.org/W2033553802","https://openalex.org/W2049661577","https://openalex.org/W2056503051","https://openalex.org/W2060129283","https://openalex.org/W2072108911","https://openalex.org/W2072840410","https://openalex.org/W2078509120","https://openalex.org/W2091631118","https://openalex.org/W2093280908","https://openalex.org/W2097390876","https://openalex.org/W2111740625","https://openalex.org/W2117498323","https://openalex.org/W2128252687","https://openalex.org/W2143169091","https://openalex.org/W2145066533","https://openalex.org/W2162804111","https://openalex.org/W2169027518","https://openalex.org/W2333294007","https://openalex.org/W3171742507"],"related_works":["https://openalex.org/W2128260029","https://openalex.org/W2007941090","https://openalex.org/W1993754429","https://openalex.org/W2054604495","https://openalex.org/W1513944579","https://openalex.org/W2330750147","https://openalex.org/W2090443943","https://openalex.org/W2018620644","https://openalex.org/W2465049460","https://openalex.org/W2033809293"],"abstract_inverted_index":{"Because":[0],"1,25-dihydroxyvitamin":[1],"D3":[2],"(1,25(OH)2D3)":[3],"has":[4],"been":[5],"shown":[6],"to":[7,219],"play":[8,240],"roles":[9],"in":[10,29,58,63,119,134,155,163,174,190,236,243],"both":[11,207],"proliferation":[12],"and":[13,90,121,136,157,197,215],"differentiation":[14],"of":[15,22,43,49,79,99,125,132,160,166,184,194,203,209,230,248],"novel":[16],"target":[17],"cells,":[18,192],"the":[19,130,138,148,164,182,195,220,228,244],"potential":[20],"expression":[21,131],"1,25(OH)2D3":[23,149,169,221],"receptor":[24],"(VDR)":[25],"activity":[26],"was":[27,93],"investigated":[28],"cultured":[30],"bovine":[31],"aortic":[32],"endothelial":[33,123,191],"cells":[34,124],"(BAEC).":[35],"Receptor":[36],"binding":[37,61],"assays":[38],"performed":[39],"on":[40],"nuclear":[41,116],"extracts":[42],"BAEC":[44,66,74,139,146,161,217],"revealed":[45],"a":[46,55,112,171,185,198,231,241],"single":[47],"class":[48],"specific,":[50],"high-affinity":[51],"VDR":[52,118,196],"that":[53,145,216,238],"displayed":[54],"4.5-fold":[56],"increase":[57],"maximal":[59],"ligand":[60],"(Nmax)":[62],"rapidly":[64],"proliferating":[65],"compared":[67],"with":[68,77],"confluent,":[69],"density-arrested":[70],"cells.":[71],"When":[72],"confluent":[73],"were":[75],"incubated":[76],"activators":[78],"protein":[80],"kinase":[81],"C":[82],"(PKC),":[83],"Nmax":[84],"increased":[85],"2.5-fold":[86],"within":[87],"6-24":[88],"h":[89],"this":[91,210,249],"upregulation":[92],"prevented":[94],"by":[95,104,223],"sphingosine,":[96],"an":[97],"inhibitor":[98],"PKC,":[100],"as":[101,103],"well":[102],"actinomycin":[105],"D":[106,187,233],"or":[107],"cycloheximide.":[108],"Immunohistochemical":[109],"visualization":[110],"using":[111],"specific":[113],"MAb":[114],"disclosed":[115],"localized":[117],"venular":[120],"capillary":[122],"human":[126],"skin":[127],"biopsies,":[128],"documenting":[129],"VDR,":[133],"vivo,":[135],"validating":[137],"model.":[140],"Finally,":[141],"additional":[142],"experiments":[143],"indicated":[144],"formed":[147],"hormonal":[150],"metabolite":[151],"from":[152],"25(OH)D3":[153],"substrate,":[154],"vitro,":[156],"growth":[158,225],"curves":[159],"maintained":[162],"presence":[165,183],"10(-8)":[167],"M":[168],"showed":[170],"36%":[172],"decrease":[173],"saturation":[175],"density.":[176],"These":[177],"data":[178],"provide":[179],"evidence":[180],"for":[181],"vitamin":[186,232],"microendocrine":[188],"system":[189,211],"consisting":[193],"1":[199],"alpha-hydroxylase":[200],"enzyme":[201],"capable":[202],"producing":[204],"1,25(OH)2D3.":[205],"That":[206],"components":[208],"are":[212],"coordinately":[213],"regulated,":[214],"respond":[218],"hormone":[222],"modulating":[224],"kinetics,":[226],"suggests":[227],"existence":[229],"autocrine":[234],"loop":[235],"endothelium":[237],"may":[239],"role":[242],"development":[245],"and/or":[246],"functions":[247],"pathophysiologically":[250],"significant":[251],"cell":[252],"population.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}