{"id":"https://openalex.org/W1975247371","doi":"https://doi.org/10.1016/j.stem.2007.06.001","title":"Lack of Evidence that Hematopoietic Stem Cells Depend on N-Cadherin-Mediated Adhesion to Osteoblasts for Their Maintenance","display_name":"Lack of Evidence that Hematopoietic Stem Cells Depend on N-Cadherin-Mediated Adhesion to Osteoblasts for Their Maintenance","publication_year":2007,"publication_date":"2007-08-01","ids":{"openalex":"https://openalex.org/W1975247371","doi":"https://doi.org/10.1016/j.stem.2007.06.001","mag":"1975247371","pmid":"https://pubmed.ncbi.nlm.nih.gov/18371351"},"language":"en","primary_location":{"id":"doi:10.1016/j.stem.2007.06.001","doi":"https://doi.org/10.1016/j.stem.2007.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stem.2007.06.001","pdf_url":"http://www.cell.com/article/S1934590907000653/pdf","source":{"id":"https://openalex.org/S128124174","display_name":"Cell stem cell","issn_l":"1875-9777","issn":["1875-9777","1934-5909"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stem Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1934590907000653/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091289908","display_name":"Mark J. Kiel","orcid":"https://orcid.org/0000-0003-0931-1983","observed_orcids":["https://orcid.org/0000-0003-0931-1983"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Kiel","raw_affiliation_strings":["Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA","Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI\u00a048109-2216, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, MI\u00a048109-2216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI\u00a048109-2216, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, MI\u00a048109-2216, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008805727","display_name":"Glenn L. Radice","orcid":"https://orcid.org/0000-0002-2944-1059","observed_orcids":["https://orcid.org/0000-0002-2944-1059"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn L. Radice","raw_affiliation_strings":["Center for Research on Reproduction and Women's Health, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Reproduction and Women's Health, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079548260","display_name":"Sean J. Morrison","orcid":"https://orcid.org/0000-0003-1587-8329","observed_orcids":["https://orcid.org/0000-0003-1587-8329"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean J. Morrison","raw_affiliation_strings":["Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI\u00a048109-2216, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, MI\u00a048109-2216, USA","Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI\u00a048109-2216, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, MI\u00a048109-2216, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079548260"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":17.2067,"has_fulltext":false,"cited_by_count":342,"citation_normalized_percentile":{"value":0.99369523,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"1","issue":"2","first_page":"204","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.859000027179718},{"id":"https://openalex.org/keywords/homophilic-adhesion","display_name":"homophilic adhesion","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hsc-maintenance","display_name":"HSC maintenance","score":0.878000020980835},{"id":"https://openalex.org/keywords/biglycan","display_name":"biglycan","score":0.8629999756813049},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.7279999852180481},{"id":"https://openalex.org/keywords/endosteum","display_name":"endosteum","score":0.7120000123977661},{"id":"https://openalex.org/keywords/bone-marrow-sinusoids","display_name":"bone marrow sinusoids","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.7819557189941406},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7253696322441101},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7171590924263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6842190623283386},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6540312170982361},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6004897356033325},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.47207000851631165},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.44118085503578186},{"id":"https://openalex.org/C2908915366","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Bone Marrow Stem Cell","level":3,"score":0.41393446922302246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3707452118396759},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25788456201553345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1661779284477234},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10987821221351624},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058578","descriptor_name":"Biglycan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.stem.2007.06.001","doi":"https://doi.org/10.1016/j.stem.2007.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stem.2007.06.001","pdf_url":"http://www.cell.com/article/S1934590907000653/pdf","source":{"id":"https://openalex.org/S128124174","display_name":"Cell stem cell","issn_l":"1875-9777","issn":["1875-9777","1934-5909"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stem Cell","raw_type":"journal-article"},{"id":"pmid:18371351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18371351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell stem cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.stem.2007.06.001","doi":"https://doi.org/10.1016/j.stem.2007.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stem.2007.06.001","pdf_url":"http://www.cell.com/article/S1934590907000653/pdf","source":{"id":"https://openalex.org/S128124174","display_name":"Cell stem cell","issn_l":"1875-9777","issn":["1875-9777","1934-5909"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stem Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2517984267","display_name":"University of Michigan Rheumatic Diseases Research Core Center","funder_award_id":"P30AR048310","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000862605","display_name":"University of Michigan Rogel Cancer Center Support Grant 2023-2028","funder_award_id":"P30CA046592","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975247371.pdf"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1491950503","https://openalex.org/W1545381643","https://openalex.org/W1549257184","https://openalex.org/W1597035250","https://openalex.org/W1975025595","https://openalex.org/W1978122265","https://openalex.org/W2006754137","https://openalex.org/W2011174877","https://openalex.org/W2014208932","https://openalex.org/W2017509374","https://openalex.org/W2017625115","https://openalex.org/W2017802236","https://openalex.org/W2017907565","https://openalex.org/W2017965105","https://openalex.org/W2021276131","https://openalex.org/W2027610354","https://openalex.org/W2027927113","https://openalex.org/W2029073164","https://openalex.org/W2036795046","https://openalex.org/W2038282968","https://openalex.org/W2039748263","https://openalex.org/W2041106449","https://openalex.org/W2060610551","https://openalex.org/W2062945727","https://openalex.org/W2068972073","https://openalex.org/W2070554668","https://openalex.org/W2070793750","https://openalex.org/W2077330278","https://openalex.org/W2080928766","https://openalex.org/W2086243699","https://openalex.org/W2088022688","https://openalex.org/W2093818708","https://openalex.org/W2100378064","https://openalex.org/W2113754447","https://openalex.org/W2119704135","https://openalex.org/W2119739306","https://openalex.org/W2120372000","https://openalex.org/W2125410884","https://openalex.org/W2140254135","https://openalex.org/W2141877739","https://openalex.org/W2344093195","https://openalex.org/W7027433782"],"related_works":["https://openalex.org/W2012326387","https://openalex.org/W2081561972","https://openalex.org/W2004856051","https://openalex.org/W648987066","https://openalex.org/W2013131199","https://openalex.org/W2979692772","https://openalex.org/W2555406655","https://openalex.org/W1851530012","https://openalex.org/W2078623934","https://openalex.org/W2014056119"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":37}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}