{"id":"https://openalex.org/W1975244653","doi":"https://doi.org/10.1007/s10928-012-9262-4","title":"Mechanism-based PK\u2013PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans","display_name":"Mechanism-based PK\u2013PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans","publication_year":2012,"publication_date":"2012-07-12","ids":{"openalex":"https://openalex.org/W1975244653","doi":"https://doi.org/10.1007/s10928-012-9262-4","mag":"1975244653","pmid":"https://pubmed.ncbi.nlm.nih.gov/22791078"},"language":"en","primary_location":{"id":"doi:10.1007/s10928-012-9262-4","doi":"https://doi.org/10.1007/s10928-012-9262-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10928-012-9262-4","pdf_url":null,"source":{"id":"https://openalex.org/S161302385","display_name":"Journal of Pharmacokinetics and Pharmacodynamics","issn_l":"1567-567X","issn":["1567-567X","1573-8744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacokinetics and Pharmacodynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085591989","display_name":"Jasper Stevens","orcid":"https://orcid.org/0000-0003-1601-9008","observed_orcids":["https://orcid.org/0000-0003-1601-9008"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jasper Stevens","raw_affiliation_strings":["Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017280045","display_name":"Bart A. Ploeger","orcid":"https://orcid.org/0000-0003-1183-7458","observed_orcids":["https://orcid.org/0000-0003-1183-7458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bart A. Ploeger","raw_affiliation_strings":["LAP&P Consultants BV, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LAP&P Consultants BV, Leiden, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091428143","display_name":"Margareta Hammarlund\u2010Udenaes","orcid":"https://orcid.org/0000-0002-9181-1321","observed_orcids":["https://orcid.org/0000-0002-9181-1321"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Margareta Hammarlund-Udenaes","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091668634","display_name":"Gunilla Osswald","orcid":"https://orcid.org/0000-0003-3620-7161","observed_orcids":["https://orcid.org/0000-0003-3620-7161"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]},{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Gunilla Osswald","raw_affiliation_strings":["AstraZeneca R&D, S\u00f6dert\u00e4lje, Sweden","AstraZeneca R&D"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D, S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]},{"raw_affiliation_string":"AstraZeneca R&D","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077172862","display_name":"Piet H. van der Graaf","orcid":"https://orcid.org/0000-0003-1314-3484","observed_orcids":["https://orcid.org/0000-0003-1314-3484"]},"institutions":[{"id":"https://openalex.org/I189718659","display_name":"Pfizer (United Kingdom)","ror":"https://ror.org/04x4v8p40","country_code":"GB","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I189718659"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Piet H. van der Graaf","raw_affiliation_strings":["Pfizer, Sandwich, Kent, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer, Sandwich, Kent, UK","institution_ids":["https://openalex.org/I189718659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033133140","display_name":"Meindert Danhof","orcid":"https://orcid.org/0000-0002-2319-6830","observed_orcids":["https://orcid.org/0000-0002-2319-6830"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Meindert Danhof","raw_affiliation_strings":["Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands","LAP&P Consultants BV, Leiden, The Netherlands","Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"LAP&P Consultants BV, Leiden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017208135","display_name":"Elizabeth C. M. de Lange","orcid":"https://orcid.org/0000-0001-8303-1117","observed_orcids":["https://orcid.org/0000-0001-8303-1117"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Elizabeth C. M. de Lange","raw_affiliation_strings":["Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands","Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017208135"],"corresponding_institution_ids":["https://openalex.org/I121797337"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":3.0892,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.91007338,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"39","issue":"5","first_page":"463","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0828000009059906,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.06129999831318855,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/remoxipride","display_name":"remoxipride","score":0.925000011920929},{"id":"https://openalex.org/keywords/dopamine-antagonism","display_name":"dopamine antagonism","score":0.7379999756813049},{"id":"https://openalex.org/keywords/lactotrophs","display_name":"lactotrophs","score":0.7379999756813049},{"id":"https://openalex.org/keywords/prolactin-secretion","display_name":"prolactin secretion","score":0.7889999747276306},{"id":"https://openalex.org/keywords/allometric-scaling","display_name":"allometric scaling","score":0.7639999985694885},{"id":"https://openalex.org/keywords/intranasal-administration","display_name":"intranasal administration","score":0.7409999966621399},{"id":"https://openalex.org/keywords/homeostatic-mechanisms","display_name":"homeostatic mechanisms","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.9050588607788086},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6377312541007996},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6334902048110962},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5978472828865051},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5833936333656311},{"id":"https://openalex.org/C54799321","wikidata":"https://www.wikidata.org/wiki/Q3016161","display_name":"Prolactin cell","level":4,"score":0.5371459722518921},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.513911247253418},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46395865082740784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4436872899532318},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.41965004801750183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2206268310546875},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17065182328224182},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14857423305511475}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017330","descriptor_name":"Remoxipride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017330","descriptor_name":"Remoxipride","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10928-012-9262-4","doi":"https://doi.org/10.1007/s10928-012-9262-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10928-012-9262-4","pdf_url":null,"source":{"id":"https://openalex.org/S161302385","display_name":"Journal of Pharmacokinetics and Pharmacodynamics","issn_l":"1567-567X","issn":["1567-567X","1573-8744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacokinetics and Pharmacodynamics","raw_type":"journal-article"},{"id":"pmid:22791078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22791078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacokinetics and pharmacodynamics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W176436028","https://openalex.org/W1517281160","https://openalex.org/W1546950378","https://openalex.org/W1925492557","https://openalex.org/W1942398841","https://openalex.org/W1964214733","https://openalex.org/W1975058882","https://openalex.org/W1976139567","https://openalex.org/W1978885695","https://openalex.org/W1983245593","https://openalex.org/W1985936594","https://openalex.org/W1992534595","https://openalex.org/W2022934702","https://openalex.org/W2023309088","https://openalex.org/W2033910397","https://openalex.org/W2042099048","https://openalex.org/W2048485144","https://openalex.org/W2066034336","https://openalex.org/W2067770236","https://openalex.org/W2073356179","https://openalex.org/W2076472674","https://openalex.org/W2079659855","https://openalex.org/W2084428071","https://openalex.org/W2088206004","https://openalex.org/W2094852419","https://openalex.org/W2098666011","https://openalex.org/W2110344582","https://openalex.org/W2111470240","https://openalex.org/W2113103296","https://openalex.org/W2123232431","https://openalex.org/W2132114003","https://openalex.org/W2140458881","https://openalex.org/W2142846515","https://openalex.org/W2154180317","https://openalex.org/W2160534829","https://openalex.org/W2164875032","https://openalex.org/W2254981029","https://openalex.org/W2266970241","https://openalex.org/W2405887519","https://openalex.org/W2416546163"],"related_works":["https://openalex.org/W1494310108","https://openalex.org/W2266970241","https://openalex.org/W2481676815","https://openalex.org/W2769546281","https://openalex.org/W2898453126","https://openalex.org/W2470865468","https://openalex.org/W2545826513","https://openalex.org/W2549835700","https://openalex.org/W2504258805","https://openalex.org/W1546950378"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
