{"id":"https://openalex.org/W1975240682","doi":"https://doi.org/10.1248/bpb.21.1094","title":"Participation of Oligomerization through C-Terminal D Domain Region of Sp1 in DNA Binding.","display_name":"Participation of Oligomerization through C-Terminal D Domain Region of Sp1 in DNA Binding.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W1975240682","doi":"https://doi.org/10.1248/bpb.21.1094","mag":"1975240682","pmid":"https://pubmed.ncbi.nlm.nih.gov/9821817"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.21.1094","doi":"https://doi.org/10.1248/bpb.21.1094","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.21.1094","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1993/21/10/21_10_1094/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb1993/21/10/21_10_1094/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111651986","display_name":"Keizo Matsushita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keizo MATSUSHITA","raw_affiliation_strings":["Institute for Chemical Research, Kyoto University, Uji, Japan","Inst. for Chemical Research, Kyoto Univ., Uji (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Chemical Research, Kyoto University, Uji, Japan","institution_ids":["https://openalex.org/I4399598384"]},{"raw_affiliation_string":"Inst. for Chemical Research, Kyoto Univ., Uji (Japan)","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001688127","display_name":"Masaki Hagihara","orcid":"https://orcid.org/0000-0002-2678-825X","observed_orcids":["https://orcid.org/0000-0002-2678-825X"]},"institutions":[{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki HAGIHARA","raw_affiliation_strings":["Institute for Chemical Research Kyoto University, Institute for Chemical Research Kyoto University, Institute for Chemical Research Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Chemical Research Kyoto University, Institute for Chemical Research Kyoto University, Institute for Chemical Research Kyoto University","institution_ids":["https://openalex.org/I4399598384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109073164","display_name":"Yukio Sugiura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukio SUGIURA","raw_affiliation_strings":["Institute for Chemical Research Kyoto University, Institute for Chemical Research Kyoto University, Institute for Chemical Research Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Chemical Research Kyoto University, Institute for Chemical Research Kyoto University, Institute for Chemical Research Kyoto University","institution_ids":["https://openalex.org/I4399598384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0969,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.32715869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"10","first_page":"1094","last_page":"1097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/zinc-finger-proteins","display_name":"zinc finger proteins","score":0.6179999709129333},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.9110000133514404},{"id":"https://openalex.org/keywords/synergistic-transcriptional-activation","display_name":"synergistic transcriptional activation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/c2h2-zinc-finger","display_name":"C2H2 zinc finger","score":0.800000011920929},{"id":"https://openalex.org/keywords/dna-binding-mode","display_name":"DNA binding modes","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.9195876121520996},{"id":"https://openalex.org/C57467964","wikidata":"https://www.wikidata.org/wiki/Q14888082","display_name":"Sp1 transcription factor","level":5,"score":0.8514751195907593},{"id":"https://openalex.org/C35802184","wikidata":"https://www.wikidata.org/wiki/Q204773","display_name":"Zinc finger nuclease","level":5,"score":0.7072672843933105},{"id":"https://openalex.org/C186055190","wikidata":"https://www.wikidata.org/wiki/Q24788168","display_name":"RING finger domain","level":5,"score":0.6791367530822754},{"id":"https://openalex.org/C5432534","wikidata":"https://www.wikidata.org/wiki/Q24722007","display_name":"LIM domain","level":5,"score":0.57899409532547},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5699795484542847},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5608014464378357},{"id":"https://openalex.org/C33347731","wikidata":"https://www.wikidata.org/wiki/Q285210","display_name":"Stacking","level":2,"score":0.5527116060256958},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.539209246635437},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5314822196960449},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.47253870964050293},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.463178426027298},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.44210436940193176},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.43669992685317993},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4030364751815796},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3830030858516693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3763844966888428},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3760051429271698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30010178685188293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2968742251396179},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.27410709857940674},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09719353914260864},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.21.1094","doi":"https://doi.org/10.1248/bpb.21.1094","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.21.1094","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1993/21/10/21_10_1094/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:9821817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9821817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.21.1094","doi":"https://doi.org/10.1248/bpb.21.1094","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.21.1094","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1993/21/10/21_10_1094/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975240682.pdf","grobid_xml":"https://content.openalex.org/works/W1975240682.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089126365","https://openalex.org/W1971963474","https://openalex.org/W2412518974","https://openalex.org/W2397601930","https://openalex.org/W2006620181","https://openalex.org/W29054273","https://openalex.org/W1992901862","https://openalex.org/W2130258789","https://openalex.org/W2124845167","https://openalex.org/W2095105515"],"abstract_inverted_index":{"Transcription":[0],"factor":[1],"Sp1":[2,26,29,40,58,68,81,101,111],"is":[3],"a":[4],"Cys2His2-type":[5],"zinc":[6,32,44],"finger":[7,33,45],"protein":[8],"that":[9,67,79],"specifically":[10],"binds":[11],"to":[12],"GC-boxes":[13],"on":[14],"numerous":[15],"viral":[16],"and":[17,35,39,47,78],"cellular":[18],"genes.":[19],"In":[20],"this":[21],"study,":[22],"we":[23],"prepared":[24],"several":[25],"mutant":[27,82],"peptides":[28],"(530-696)":[30],"containing":[31,42,83],"region":[34],"the":[36,50,53,80,84,97,103],"domain":[37,55,85],"D,":[38],"(530--623)":[41,77],"only":[43],"region,":[46],"then":[48],"investigated":[49],"participation":[51],"of":[52,57,100,105],"C-terminal":[54],"D":[56,86,90],"for":[59,110],"GC-box":[60],"binding.":[61],"Gel":[62],"mobility":[63],"shift":[64],"assays":[65],"demonstrate":[66],"(530--696)":[69],"evidently":[70],"shows":[71],"DNA-binding":[72],"modes":[73],"different":[74],"from":[75],"Spl":[76],"self-interacts":[87],"directly.":[88],"Domain":[89],"may":[91],"play":[92],"an":[93],"important":[94],"role":[95],"in":[96],"synergistic":[98],"activation":[99],"by":[102],"stacking":[104],"tetramers.":[106],"A":[107],"novel":[108],"model":[109],"oligomerization":[112],"has":[113],"also":[114],"been":[115],"proposed.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
