{"id":"https://openalex.org/W1975220136","doi":"https://doi.org/10.1002/hon.799","title":"Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non\u2010Hodgkin's lymphoma","display_name":"Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non\u2010Hodgkin's lymphoma","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W1975220136","doi":"https://doi.org/10.1002/hon.799","mag":"1975220136","pmid":"https://pubmed.ncbi.nlm.nih.gov/16948177"},"language":"en","primary_location":{"id":"doi:10.1002/hon.799","doi":"https://doi.org/10.1002/hon.799","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hon.799","pdf_url":null,"source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052988000","display_name":"Suzanne E. Biehn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suzanne E. Biehn","raw_affiliation_strings":["University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7295, USA. suzanne_biehn@med.unc.edu","University of North Carolina at Chapel Hill School of Medicine, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7295, USA. suzanne_biehn@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill School of Medicine, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108361289","display_name":"David Kirk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Kirk","raw_affiliation_strings":["Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill School of Medicine, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill School of Medicine, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056966868","display_name":"M. Patricia Rivera","orcid":"https://orcid.org/0000-0003-3827-5010","observed_orcids":["https://orcid.org/0000-0003-3827-5010"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Patricia Rivera","raw_affiliation_strings":["Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill School of Medicine, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill School of Medicine, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103537901","display_name":"Antonio E. Mart\u00ednez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio E. Martinez","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Division of Hematopathology, University of North Carolina at Chapel Hill School of Medicine, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Division of Hematopathology, University of North Carolina at Chapel Hill School of Medicine, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034953398","display_name":"Amir Hossein Khandani","orcid":"https://orcid.org/0000-0003-3629-5472","observed_orcids":["https://orcid.org/0000-0003-3629-5472"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amir H. Khandani","raw_affiliation_strings":["Department of Radiology, Division of Nuclear Medicine, University of North Carolina at Chapel Hill School of Medicine, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Division of Nuclear Medicine, University of North Carolina at Chapel Hill School of Medicine, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038235561","display_name":"Robert Zygmunt Orlowski","orcid":"https://orcid.org/0000-0002-5723-4129","observed_orcids":["https://orcid.org/0000-0002-5723-4129"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Z. Orlowski","raw_affiliation_strings":["Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill School of Medicine, NC, USA","Department of Pharmacology, University of North Carolina at Chapel Hill, NC, USA","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, NC, USA","University of North Carolina at Chapel Hill School of Medicine, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill School of Medicine, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, NC, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill School of Medicine, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052988000"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":4.6651,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.94582383,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"4","first_page":"234","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.4927000105381012,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.4927000105381012,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.2498999983072281,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0674000009894371,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bronchiolitis-obliterans-with-organizing-pneumonia","display_name":"bronchiolitis obliterans with organizing pneumonia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9819999933242798},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pulmonary-complications","display_name":"pulmonary complications","score":0.531000018119812},{"id":"https://openalex.org/keywords/anti-cd20-monoclonal-antibody","display_name":"anti-CD20 monoclonal antibody","score":0.8989999890327454},{"id":"https://openalex.org/keywords/drug-induced-lung-injury","display_name":"drug-induced lung injury","score":0.6840000152587891},{"id":"https://openalex.org/keywords/b-cell-non-hodgkin-lymphoma","display_name":"B-cell non-Hodgkin lymphoma","score":0.8339999914169312},{"id":"https://openalex.org/keywords/differential-diagnosis-of-pulmonary-nodules","display_name":"differential diagnosis of lung nodules","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.9401358962059021},{"id":"https://openalex.org/C2777677276","wikidata":"https://www.wikidata.org/wiki/Q2012642","display_name":"Bronchiolitis obliterans organizing pneumonia","level":5,"score":0.9079524278640747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8966966867446899},{"id":"https://openalex.org/C2776739411","wikidata":"https://www.wikidata.org/wiki/Q614750","display_name":"Bronchiolitis obliterans","level":4,"score":0.711897611618042},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6387490034103394},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.4509361684322357},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.44468653202056885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3671060800552368},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3536461591720581},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35010626912117004},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.34686899185180664},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2271961271762848},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018549","descriptor_name":"Cryptogenic Organizing Pneumonia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D018549","descriptor_name":"Cryptogenic Organizing Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018549","descriptor_name":"Cryptogenic Organizing Pneumonia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058846","descriptor_name":"Antibodies, Monoclonal, Murine-Derived","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hon.799","doi":"https://doi.org/10.1002/hon.799","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hon.799","pdf_url":null,"source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},{"id":"pmid:16948177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16948177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological oncology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7599999904632568}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G2108575099","display_name":"Dual Proteasome and MAPK Inhibition in Cancer Therapy","funder_award_id":"R01CA102278","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4056340488","display_name":null,"funder_award_id":"RR-000046","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4137263475","display_name":"General Clinical Research Center","funder_award_id":"M01RR000046","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W206701898","https://openalex.org/W1881313440","https://openalex.org/W1915689252","https://openalex.org/W1965355357","https://openalex.org/W1988217711","https://openalex.org/W1989045099","https://openalex.org/W1991467275","https://openalex.org/W2010787620","https://openalex.org/W2014894779","https://openalex.org/W2024139064","https://openalex.org/W2037346751","https://openalex.org/W2065099367","https://openalex.org/W2077582030","https://openalex.org/W2088428510","https://openalex.org/W2090477756","https://openalex.org/W2099314298","https://openalex.org/W2104940816","https://openalex.org/W2134839986","https://openalex.org/W2137699411","https://openalex.org/W2156566678","https://openalex.org/W2264636885","https://openalex.org/W2417730399"],"related_works":["https://openalex.org/W2151519319","https://openalex.org/W2045861790","https://openalex.org/W2028217419","https://openalex.org/W2580260363","https://openalex.org/W2156566678","https://openalex.org/W7220360115","https://openalex.org/W2040039840","https://openalex.org/W2525800367","https://openalex.org/W2031094478","https://openalex.org/W2006128121"],"abstract_inverted_index":{"Rituximab":[0],"is":[1,18,67],"a":[2,46,104],"chimeric,":[3],"anti-CD20":[4],"monoclonal":[5],"antibody":[6],"initially":[7],"approved":[8],"for":[9],"relapsed,":[10],"refractory":[11],"indolent":[12],"B-cell":[13],"non-Hodgkin's":[14],"lymphoma":[15],"(NHL),":[16],"and":[17,38,55,78,145],"being":[19],"applied":[20],"in":[21,94],"an":[22,34,49],"increasing":[23],"variety":[24],"of":[25,48,72,92,103,114,133,139,143],"clinical":[26],"scenarios.":[27],"Most":[28],"adverse":[29],"events":[30],"are":[31,42],"due":[32],"to":[33],"infusion-related":[35],"symptom":[36],"complex,":[37],"severe":[39],"pulmonary":[40,147],"complications":[41],"rare.":[43],"We":[44],"describe":[45],"case":[47,71],"NHL":[50,95],"patient":[51],"who":[52],"received":[53],"rituximab":[54,117,129],"developed":[56],"symptomatic,":[57],"biopsy-proven":[58],"multinodular":[59],"bronchiolitis":[60],"obliterans":[61],"with":[62,75,80],"organizing":[63],"pneumonia":[64],"(BOOP).":[65],"This":[66],"the":[68,101,112,137],"first":[69],"reported":[70],"BOOP":[73,93,115,144],"associated":[74],"single-agent":[76],"rituximab,":[77],"along":[79],"two":[81,89],"other":[82],"patients":[83,96],"we":[84],"describe,":[85],"as":[86,88],"well":[87],"prior":[90],"reports":[91],"receiving":[97],"rituximab-based":[98],"combinations,":[99],"strengthens":[100],"possibility":[102],"causal":[105],"relationship.":[106],"Moreover,":[107],"these":[108],"findings":[109],"suggest":[110],"that":[111],"incidence":[113],"following":[116],"therapy":[118],"may":[119],"be":[120,131],"higher":[121],"than":[122],"has":[123],"been":[124],"previously":[125],"appreciated.":[126],"Physicians":[127],"utilizing":[128],"should":[130],"aware":[132],"this":[134],"association":[135],"given":[136],"difficulty":[138],"differentiating":[140],"between":[141],"presentations":[142],"neoplastic":[146],"processes.":[148]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}