{"id":"https://openalex.org/W1975201760","doi":"https://doi.org/10.1016/s0006-291x(05)80321-3","title":"Apolipoprotein B genetic polymorphisms in several human hepatoma derived liver cell lines","display_name":"Apolipoprotein B genetic polymorphisms in several human hepatoma derived liver cell lines","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W1975201760","doi":"https://doi.org/10.1016/s0006-291x(05)80321-3","mag":"1975201760","pmid":"https://pubmed.ncbi.nlm.nih.gov/1348933"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-291x(05)80321-3","doi":"https://doi.org/10.1016/s0006-291x(05)80321-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-291x(05)80321-3","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019014457","display_name":"Miguel T. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel T. Robinson","raw_affiliation_strings":["Lawrence Berkeley Laboratory, California 94720","Lawrence Berkeley Laboratory, 1 Cyclotron Road, Berkeley, California, 94720. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley Laboratory, California 94720","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Lawrence Berkeley Laboratory, 1 Cyclotron Road, Berkeley, California, 94720. USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112030037","display_name":"Mark R. McCall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. McCall","raw_affiliation_strings":["Lawrence Berkeley Laboratory 1 Cyclotron Road Berkeley, California 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley Laboratory 1 Cyclotron Road Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108111190","display_name":"Edward M. Rubin","orcid":"https://orcid.org/0000-0002-9862-8677","observed_orcids":["https://orcid.org/0000-0002-9862-8677","https://orcid.org/0000-0001-9205-7079"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Rubin","raw_affiliation_strings":["Lawrence Berkeley Laboratory 1 Cyclotron Road Berkeley, California 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley Laboratory 1 Cyclotron Road Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephen Lauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Lauer","raw_affiliation_strings":["Gladstone Foundation P.O. Box 40608, San Francisco, California 94140-0608, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Foundation P.O. Box 40608, San Francisco, California 94140-0608, USA","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078419556","display_name":"Michael La Belle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael La Belle","raw_affiliation_strings":["Lawrence Berkeley Laboratory 1 Cyclotron Road Berkeley, California 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley Laboratory 1 Cyclotron Road Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113654507","display_name":"Trudy M. Forte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Trudy M. Forte","raw_affiliation_strings":["Lawrence Berkeley Laboratory 1 Cyclotron Road Berkeley, California 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley Laboratory 1 Cyclotron Road Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I148283060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113654507"],"corresponding_institution_ids":["https://openalex.org/I148283060"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10816146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"183","issue":"3","first_page":"1224","last_page":"1229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hepatoma-cell-lines","display_name":"hepatoma cell lines","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ecori-restriction-site","display_name":"EcoRI restriction site","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lipid-secretion","display_name":"lipid secretion","score":0.6850000023841858},{"id":"https://openalex.org/keywords/triglyceride-accumulation","display_name":"triglyceride accumulation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cholesterol-accumulation","display_name":"cholesterol accumulation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/apolipoprotein-b-secretion","display_name":"apolipoprotein B secretion","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.84443199634552},{"id":"https://openalex.org/C130123407","wikidata":"https://www.wikidata.org/wiki/Q417754","display_name":"EcoRI","level":4,"score":0.6769891381263733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6517389416694641},{"id":"https://openalex.org/C81566733","wikidata":"https://www.wikidata.org/wiki/Q1047544","display_name":"Hypervariable region","level":3,"score":0.530853807926178},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48411595821380615},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4602543115615845},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4475105106830597},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4399813711643219},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4396418631076813},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.4312421679496765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3381044864654541},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3018791377544403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1180213987827301},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.10688826441764832},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015246","descriptor_name":"Deoxyribonuclease EcoRI","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015252","descriptor_name":"Deoxyribonucleases, Type II Site-Specific","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-291x(05)80321-3","doi":"https://doi.org/10.1016/s0006-291x(05)80321-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-291x(05)80321-3","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:1348933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1348933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1151930840","display_name":"LIPOPROTEINS AND ATHEROGENESIS IN TRANSGENIC ANIMALS","funder_award_id":"5p01hl018574-26","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1634165384","display_name":null,"funder_award_id":"RR05918","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G271182148","display_name":null,"funder_award_id":"HL-07279","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G625077429","display_name":null,"funder_award_id":"HL-18574","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8171298664","display_name":"Comparative Genomics of Cardiovascular Gene Regulation","funder_award_id":"T32HL007279","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8903514277","display_name":"BIOMEDICAL RESEARCH SUPPORT GRANT","funder_award_id":"2s07rr005918-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1510707687","https://openalex.org/W1544186436","https://openalex.org/W1552527636","https://openalex.org/W1769058105","https://openalex.org/W1975435592","https://openalex.org/W1975887337","https://openalex.org/W2014669590","https://openalex.org/W2015782283","https://openalex.org/W2032118018","https://openalex.org/W2033553129","https://openalex.org/W2048934789","https://openalex.org/W2050651538","https://openalex.org/W2056656472","https://openalex.org/W2060333964","https://openalex.org/W2067034223","https://openalex.org/W2088618132","https://openalex.org/W2091684338","https://openalex.org/W2092646080","https://openalex.org/W2119987270","https://openalex.org/W2141624261","https://openalex.org/W2150691756","https://openalex.org/W2168003580","https://openalex.org/W2326731184","https://openalex.org/W2338151611"],"related_works":["https://openalex.org/W2103006002","https://openalex.org/W2088099669","https://openalex.org/W2156763097","https://openalex.org/W2008485598","https://openalex.org/W2351894622","https://openalex.org/W2131621393","https://openalex.org/W4412600137","https://openalex.org/W4400952426","https://openalex.org/W2040764616","https://openalex.org/W2045289688"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}