{"id":"https://openalex.org/W1975138994","doi":"https://doi.org/10.5584/jiomics.v1i2.36","title":"Quantitative Proteomic Analysis of Retina in Oxygen-Induced Retinopathy Mice using iTRAQ with 2D NanoLC-nanoESI-MS/MS","display_name":"Quantitative Proteomic Analysis of Retina in Oxygen-Induced Retinopathy Mice using iTRAQ with 2D NanoLC-nanoESI-MS/MS","publication_year":2011,"publication_date":"2011-12-31","ids":{"openalex":"https://openalex.org/W1975138994","doi":"https://doi.org/10.5584/jiomics.v1i2.36","mag":"1975138994"},"language":"en","primary_location":{"id":"doi:10.5584/jiomics.v1i2.36","doi":"https://doi.org/10.5584/jiomics.v1i2.36","is_oa":true,"landing_page_url":"https://doi.org/10.5584/jiomics.v1i2.36","pdf_url":null,"source":{"id":"https://openalex.org/S4210230835","display_name":"Journal of Integrated OMICS","issn_l":"2182-0287","issn":["2182-0287"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrated OMICS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5584/jiomics.v1i2.36","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger Wilmer Beuerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674991","display_name":"Lei Zhou","orcid":"https://orcid.org/0000-0001-5893-6002","observed_orcids":["https://orcid.org/0000-0001-5893-6002","https://orcid.org/0000-0001-8251-3974","https://orcid.org/0009-0007-9394-309X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088180736","display_name":"Xinling Liu","orcid":"https://orcid.org/0000-0003-3106-670X","observed_orcids":["https://orcid.org/0000-0003-3106-670X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinling Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103462698","display_name":"Siew Kwan Koh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siew Kwan Koh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100409015","display_name":"Xiaorong Li","orcid":"https://orcid.org/0000-0003-0641-2797","observed_orcids":["https://orcid.org/0000-0003-0641-2797","https://orcid.org/0009-0007-2325-4512","https://orcid.org/0009-0006-8583-2341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaorong Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3781,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.49071846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.44920000433921814,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.44920000433921814,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.21770000457763672,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.15369999408721924,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxygen-induced-retinopathy","display_name":"oxygen-induced retinopathy","score":0.972000002861023},{"id":"https://openalex.org/keywords/retinal-proteome","display_name":"retinal proteome","score":0.8199999928474426},{"id":"https://openalex.org/keywords/retinal-neovascularization","display_name":"retinal neovascularization","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/blood-retinal-barrier-breakdown","display_name":"blood-retinal barrier breakdown","score":0.7960000038146973},{"id":"https://openalex.org/keywords/crystallins","display_name":"crystallins","score":0.6700000166893005},{"id":"https://openalex.org/keywords/retinoschisin","display_name":"retinoschisin","score":0.859000027179718},{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.8529999852180481},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ribosomal-proteins","display_name":"ribosomal proteins","score":0.7910000085830688},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.6449999809265137},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/retinopathy-of-prematurity","display_name":"retinopathy of prematurity","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.744488000869751},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.4920589327812195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4074215888977051},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.39452168345451355},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3909553289413452},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33104538917541504},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19409886002540588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18394118547439575},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14885270595550537},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5584/jiomics.v1i2.36","doi":"https://doi.org/10.5584/jiomics.v1i2.36","is_oa":true,"landing_page_url":"https://doi.org/10.5584/jiomics.v1i2.36","pdf_url":null,"source":{"id":"https://openalex.org/S4210230835","display_name":"Journal of Integrated OMICS","issn_l":"2182-0287","issn":["2182-0287"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrated OMICS","raw_type":"journal-article"},{"id":"pmh:oai:ojs2.www.jiomics.com:article/38","doi":null,"is_oa":true,"landing_page_url":"https://jiomics.com/index.php/jiomics/article/view/38","pdf_url":"https://jiomics.com/index.php/jiomics/article/download/38/34","source":{"id":"https://openalex.org/S4210230835","display_name":"Journal of Integrated OMICS","issn_l":"2182-0287","issn":["2182-0287"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"2182-0287","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.5584/jiomics.v1i2.36","doi":"https://doi.org/10.5584/jiomics.v1i2.36","is_oa":true,"landing_page_url":"https://doi.org/10.5584/jiomics.v1i2.36","pdf_url":null,"source":{"id":"https://openalex.org/S4210230835","display_name":"Journal of Integrated OMICS","issn_l":"2182-0287","issn":["2182-0287"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrated OMICS","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975138994.pdf","grobid_xml":"https://content.openalex.org/works/W1975138994.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1479227603","https://openalex.org/W1538850399","https://openalex.org/W1562028693","https://openalex.org/W1598597199","https://openalex.org/W1929670786","https://openalex.org/W1964675499","https://openalex.org/W1967821317","https://openalex.org/W1985965517","https://openalex.org/W1991425735","https://openalex.org/W1992159395","https://openalex.org/W1995971435","https://openalex.org/W2006291872","https://openalex.org/W2007855153","https://openalex.org/W2010394020","https://openalex.org/W2012398393","https://openalex.org/W2022084143","https://openalex.org/W2022263796","https://openalex.org/W2029855493","https://openalex.org/W2031345309","https://openalex.org/W2036408537","https://openalex.org/W2039676145","https://openalex.org/W2041550090","https://openalex.org/W2044753638","https://openalex.org/W2046394552","https://openalex.org/W2048685120","https://openalex.org/W2058442554","https://openalex.org/W2066321210","https://openalex.org/W2075086348","https://openalex.org/W2079935594","https://openalex.org/W2080554031","https://openalex.org/W2080846111","https://openalex.org/W2099592646","https://openalex.org/W2105542269","https://openalex.org/W2114364048","https://openalex.org/W2123910376","https://openalex.org/W2127083467","https://openalex.org/W2128551274","https://openalex.org/W2136501493","https://openalex.org/W2141494323","https://openalex.org/W2143349983","https://openalex.org/W2148152464","https://openalex.org/W2167075028","https://openalex.org/W2167247799","https://openalex.org/W2422911216"],"related_works":["https://openalex.org/W7214867069","https://openalex.org/W2324539199","https://openalex.org/W2087592072","https://openalex.org/W2995568442","https://openalex.org/W2883673917","https://openalex.org/W4395685585","https://openalex.org/W3029477478","https://openalex.org/W3035599572","https://openalex.org/W2917876213","https://openalex.org/W6977275502"],"abstract_inverted_index":{"Analysis":[0],"of":[1,17,28,134,142,160,167,174,192,219],"retina":[2,107,225],"proteome":[3,95],"during":[4],"the":[5,18,89,93,132,140,143,217],"hypoxia-induced":[6],"retinal":[7,94,220],"neovascularization":[8,221],"(RN)":[9],"process":[10],"may":[11],"be":[12],"helpful":[13],"to":[14,42,86],"elucidate":[15],"pathogenesis":[16,218],"related":[19,224],"diseases,":[20],"such":[21,163],"as":[22,164],"diabetic":[23],"retinopathy":[24,27,66],"(DR)":[25],"and":[26,64,98,126,158,186,222],"prematurity":[29],"(ROP).":[30],"RN":[31],"model":[32],"was":[33,197],"induced":[34,118],"in":[35,52,92,121,208],"C57BL/6":[36],"mice":[37,41,68],"by":[38,49,200],"exposing":[39],"7-day-old":[40],"75%":[43],"oxygen":[44],"for":[45,71,215],"5":[46,50],"days":[47,51],"followed":[48],"room":[53],"air.":[54],"Retina":[55],"tissues":[56],"at":[57,110],"postnatal":[58],"day":[59],"17":[60],"from":[61,96,105],"both":[62],"control":[63,97],"oxygen-induced":[65],"(OIR)":[67],"were":[69,108],"used":[70],"proteomic":[72,79,205],"analysis.":[73,203],"We":[74],"have":[75],"employed":[76],"a":[77,111,135,179,193],"quantitative":[78],"approach,":[80],"iTRAQ":[81,190],"coupled":[82],"with":[83],"2D":[84],"nanoLC-nanoESI-MS/MS":[85],"quantitatively":[87],"compare":[88],"relative":[90],"changes":[91,120,130],"OIR":[99,117],"mice.":[100],"In":[101],"total,":[102],"264":[103],"proteins":[104,123,138],"mouse":[106],"identified":[109],"95%":[112],"confidence":[113],"level.":[114],"Among":[115],"them,":[116],"significant":[119],"28":[122],"(14":[124],"up-regulated":[125],"14":[127],"down-regulated).":[128],"Obvious":[129],"include":[131],"up-regulation":[133],"few":[136],"plasma":[137],"(indicating":[139],"breakdown":[141],"blood-retina":[144],"barrier)":[145],"vimentin,":[146],"ribosomal":[147],"proteins,":[148],"some":[149],"proteases,":[150],"neural":[151],"cell":[152],"adhesion":[153],"molecule":[154],"(NCAM)":[155],"180,":[156],"retinoschisin":[157],"down-regulation":[159],"several":[161],"crystallins":[162],"isoform":[165,172],"1":[166],"\u03b1":[168,175],"crystallin":[169,176,180,184,194],"A":[170,177],"chain,":[171,178,182],"2":[173],"B":[181,195],"g":[183],"D":[185],"b-A3/A1":[187],"crystallin.":[188],"The":[189,204],"result":[191],"chain":[196],"also":[198],"confirmed":[199],"Western":[201],"blot":[202],"results":[206],"showed":[207],"this":[209],"study":[210],"should":[211],"provide":[212],"new":[213],"avenues":[214],"understanding":[216],"its":[223],"diseases.":[226]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}