{"id":"https://openalex.org/W1975129669","doi":"https://doi.org/10.1118/1.2761247","title":"MO\u2010D\u2010M100J\u201005: Robust Optimization to Accommodate Effects of Systematic Treatment Uncertainties","display_name":"MO\u2010D\u2010M100J\u201005: Robust Optimization to Accommodate Effects of Systematic Treatment Uncertainties","publication_year":2007,"publication_date":"2007-06-01","ids":{"openalex":"https://openalex.org/W1975129669","doi":"https://doi.org/10.1118/1.2761247","mag":"1975129669"},"language":"en","primary_location":{"id":"doi:10.1118/1.2761247","doi":"https://doi.org/10.1118/1.2761247","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.2761247","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073486426","display_name":"E Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Lee","raw_affiliation_strings":["Georgia Institute of Technology, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041488939","display_name":"Kyungduck Cha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Cha","raw_affiliation_strings":["Georgia Institute of Technology, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000777470","display_name":"Thomas R Bortfeld","orcid":"https://orcid.org/0000-0002-3883-0398","observed_orcids":["https://orcid.org/0000-0002-3883-0398"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Bortfeld","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026159944","display_name":"Joseph O. Deasy","orcid":"https://orcid.org/0000-0002-9437-266X","observed_orcids":["https://orcid.org/0000-0002-9437-266X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Deasy","raw_affiliation_strings":["Washington Univ, Saint Louis, MO","Washington University, Saint Louis,\u00a0MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington Univ, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University, Saint Louis,\u00a0MO","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10792334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"6Part16","first_page":"2523","last_page":"2524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robust-treatment-planning","display_name":"robust treatment planning","score":0.7699999809265137},{"id":"https://openalex.org/keywords/mixed-integer-linear-programming","display_name":"mixed-integer linear programming","score":0.8840000033378601},{"id":"https://openalex.org/keywords/4d-ct","display_name":"4D-CT","score":0.8230000138282776},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6850000023841858},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":1.0},{"id":"https://openalex.org/keywords/internal-target-volume","display_name":"internal target volume","score":0.8820000290870667},{"id":"https://openalex.org/keywords/organs-at-risk-dose-reduction","display_name":"organs at risk dose reduction","score":0.7730000019073486},{"id":"https://openalex.org/keywords/breathing-phase","display_name":"breathing phase","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.6930949687957764},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.6281213760375977},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.5817164182662964},{"id":"https://openalex.org/C193254401","wikidata":"https://www.wikidata.org/wiki/Q2160088","display_name":"Robust optimization","level":2,"score":0.4875287711620331},{"id":"https://openalex.org/C39300077","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Breathing","level":2,"score":0.48448726534843445},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.46672454476356506},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4559822678565979},{"id":"https://openalex.org/C2776292839","wikidata":"https://www.wikidata.org/wiki/Q5179217","display_name":"Coverage probability","level":3,"score":0.4526701271533966},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.40593528747558594},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.39811092615127563},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3490866422653198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3070783317089081},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2874138057231903},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.15467342734336853},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.13691967725753784},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1118/1.2761247","doi":"https://doi.org/10.1118/1.2761247","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.2761247","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2575278434","https://openalex.org/W7124973713","https://openalex.org/W815549572","https://openalex.org/W2792287665","https://openalex.org/W2610681822","https://openalex.org/W7161262440","https://openalex.org/W2938953575","https://openalex.org/W3205458065","https://openalex.org/W1436734099","https://openalex.org/W2979798872"],"abstract_inverted_index":{"Uncertainties":[0],"in":[1,104,112,170,216,269,279,288],"the":[2,43,46,75,78,106,118,166,262,295],"precise":[3],"locations":[4],"of":[5,13,45,77,108,125,168,191,259,272],"tumor":[6,64,79,296],"voxels":[7],"are":[8,70,140,186],"inherent":[9],"for":[10],"a":[11,81,85,109,113,145,150,277],"variety":[12],"reasons.":[14],"It":[15,89],"is":[16,115,163],"therefore":[17],"desirable":[18],"to":[19,27,188,195,282,294],"take":[20],"those":[21],"uncertainties":[22],"into":[23],"account,":[24],"and":[25,61,197,201,211,223,227,233,245,264,284,287],"further,":[26],"derive":[28],"treatment":[29,54,102,137,270],"planning":[30,138,143],"methodologies":[31],"that":[32,52],"directly":[33],"utilize":[34],"information":[35],"(e.g.":[36],"probability":[37,76,107],"distributions":[38],"or":[39],"actual":[40],"trajectories)":[41],"about":[42],"location":[44],"target,":[47],"including":[48],"spatial":[49],"uncertainties,":[50],"so":[51],"resulting":[53],"plans":[55,103,203,271],"exhibit":[56],"normal":[57,285],"tissue":[58],"dose":[59,82,99,119,281,293],"reduction,":[60],"potentially":[62],"higher":[63,212,292],"doses.":[65],"Two":[66],"novel":[67],"robust":[68],"approaches":[69,266],"investigated.":[71],"1)Under\u2010dose":[72],"probability(UDP)":[73],"estimates":[74],"receiving":[80],"less":[83],"than":[84],"user\u2010defined":[86],"critical":[87],"dose.":[88],"can":[90,267],"be":[91],"modeled":[92],"using":[93],"linear":[94],"mixed\u2010integer":[95],"programming":[96],"techniques.":[97],"2)Probability":[98],"generation(PDG)":[100],"designs":[101],"which":[105],"voxel":[110],"located":[111],"target":[114],"factored":[116],"during":[117,129],"generation":[120],"process.":[121],"Utilizing":[122],"4D\u2010CT":[123],"scans":[124],"lung/liver":[126],"cancer":[127],"patients":[128],"different":[130],"breathing":[131,172],"phases(phases":[132],"0\u20139,":[133],"0:full\u2010inhale,":[134],"5:full\u2010exhale),":[135],"four":[136],"strategies":[139],"compared.":[141],"1)Standard":[142],"with":[144,176,256],"static":[146],"PTV":[147],"based":[148],"on":[149],"single":[151],"selected":[152],"phase":[153],"(control).":[154],"2)The":[155],"Internal":[156],"Target":[157],"Volume":[158],"(ITV)":[159],"approach,":[160],"where":[161],"ITV":[162,198],"defined":[164],"as":[165],"union":[167],"CTVs":[169],"all":[171],"phases.":[173],"3)Plans":[174],"obtained":[175,179],"UDP.":[177],"4)Plans":[178],"via":[180],"PDG.":[181],"Sophisticated":[182],"computational":[183],"optimization":[184],"techniques":[185],"used":[187],"solve":[189],"each":[190],"these":[192],"models.":[193],"Compared":[194],"Standard":[196],"plans,":[199],"UDP":[200,228,250,263],"PDG":[202,218,239,265],"offer":[204],"good":[205],"coverage,":[206],"comparable":[207],"min\u2010PTV\u2010dose,":[208],"improved":[209,257],"PTV\u2010conformity,":[210],"PTV\u2010dose.":[213],"In":[214,237],"addition,":[215],"lung,":[217],"reduces":[219,229,240,251],"normal\u2010lung\u2010mean\u2010dose":[220],"by":[221,225,231,235,243,247,253],"13%":[222],"heart\u2010mean\u2010dose":[224,234],"20%;":[226],"esophagus\u2010mean\u2010dose":[230],"70%":[232],"49%.":[236],"liver,":[238],"normal\u2010liver\u2010":[241],"mean\u2010dose":[242],"8%":[244],"other\u2010normal\u2010tissue\u2010mean\u2010dose":[246],"26%,":[248],"whereas":[249],"normal\u2010liver\u2010mean\u2010dose":[252],"10%,":[254],"both":[255],"PTV\u2010conformity":[258],"7%.":[260],"Thus,":[261],"result":[268],"increased":[273],"robustness,":[274],"they":[275],"allow":[276],"reduction":[278],"mean":[280],"organs\u2010at\u2010risk":[283],"tissue,":[286],"some":[289],"cases,":[290],"deliver":[291],"volume.":[297]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}