{"id":"https://openalex.org/W1975110672","doi":"https://doi.org/10.1021/pr200960u","title":"Urine Metabolic Signature of Pancreatic Ductal Adenocarcinoma by 1H Nuclear Magnetic Resonance: Identification, Mapping, and Evolution","display_name":"Urine Metabolic Signature of Pancreatic Ductal Adenocarcinoma by 1H Nuclear Magnetic Resonance: Identification, Mapping, and Evolution","publication_year":2011,"publication_date":"2011-11-08","ids":{"openalex":"https://openalex.org/W1975110672","doi":"https://doi.org/10.1021/pr200960u","mag":"1975110672","pmid":"https://pubmed.ncbi.nlm.nih.gov/22066465"},"language":"en","primary_location":{"id":"doi:10.1021/pr200960u","doi":"https://doi.org/10.1021/pr200960u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr200960u","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Claudia Napoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Napoli","raw_affiliation_strings":["Bruker Italia, Milan, Italy","Department of Biotechnology and, University of Verona, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bruker Italia, Milan, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Biotechnology and, University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070509674","display_name":"Nicola Sperandio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094363","display_name":"Azienda Ospedaliera Universitaria Integrata Verona","ror":"https://ror.org/00sm8k518","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094363"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Sperandio","raw_affiliation_strings":["ARC-NET Center for Applied Research on Cancer, Verona University Hospital, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARC-NET Center for Applied Research on Cancer, Verona University Hospital, Verona, Italy","institution_ids":["https://openalex.org/I4210094363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045331477","display_name":"Rita  Teresa Lawlor","orcid":"https://orcid.org/0000-0003-3160-0634","observed_orcids":["https://orcid.org/0000-0003-3160-0634"]},"institutions":[{"id":"https://openalex.org/I4210094363","display_name":"Azienda Ospedaliera Universitaria Integrata Verona","ror":"https://ror.org/00sm8k518","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094363"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rita T. Lawlor","raw_affiliation_strings":["ARC-NET Center for Applied Research on Cancer, Verona University Hospital, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARC-NET Center for Applied Research on Cancer, Verona University Hospital, Verona, Italy","institution_ids":["https://openalex.org/I4210094363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003507376","display_name":"Aldo Scarpa","orcid":"https://orcid.org/0000-0003-1678-739X","observed_orcids":["https://orcid.org/0000-0003-1678-739X"]},"institutions":[{"id":"https://openalex.org/I4210094363","display_name":"Azienda Ospedaliera Universitaria Integrata Verona","ror":"https://ror.org/00sm8k518","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094363"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aldo Scarpa","raw_affiliation_strings":["ARC-NET Center for Applied Research on Cancer, Verona University Hospital, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARC-NET Center for Applied Research on Cancer, Verona University Hospital, Verona, Italy","institution_ids":["https://openalex.org/I4210094363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005338945","display_name":"Henriette Molinari","orcid":"https://orcid.org/0000-0002-3678-130X","observed_orcids":["https://orcid.org/0000-0002-3678-130X"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Henriette Molinari","raw_affiliation_strings":["\u2020 Department of Biotechnology and \u2225 Department of Pathology and Diagnostics, University of Verona, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Biotechnology and \u2225 Department of Pathology and Diagnostics, University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023847209","display_name":"Michael Assfalg","orcid":"https://orcid.org/0000-0001-9331-3169","observed_orcids":["https://orcid.org/0000-0001-9331-3169"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michael Assfalg","raw_affiliation_strings":["\u2020 Department of Biotechnology and \u2225 Department of Pathology and Diagnostics, University of Verona, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Biotechnology and \u2225 Department of Pathology and Diagnostics, University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023847209"],"corresponding_institution_ids":["https://openalex.org/I119439378"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1808,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.92619655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"11","issue":"2","first_page":"1274","last_page":"1283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/urinary-metabolome","display_name":"urinary metabolome","score":0.8479999899864197},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.75},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.5529999732971191},{"id":"https://openalex.org/keywords/disease-staging","display_name":"disease staging","score":0.44600000977516174},{"id":"https://openalex.org/keywords/tumor-localization","display_name":"tumor localization","score":0.8259999752044678},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.675000011920929},{"id":"https://openalex.org/keywords/metabolic-signatures","display_name":"metabolic signatures","score":0.5580000281333923},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8454078435897827},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.7863961458206177},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.5595843195915222},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5523159503936768},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.4822750389575958},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4742790162563324},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.46238628029823303},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4326319098472595},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4293784499168396},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.4160420596599579},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.382060170173645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37747636437416077},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2929458022117615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25931939482688904},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1738782525062561},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1615258753299713},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1422109305858612},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/pr200960u","doi":"https://doi.org/10.1021/pr200960u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr200960u","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmid:22066465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22066465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/16","score":0.41999998688697815,"display_name":"Peace, justice, and strong institutions"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W187554151","https://openalex.org/W1500816076","https://openalex.org/W1969889522","https://openalex.org/W1991429659","https://openalex.org/W2003414488","https://openalex.org/W2009301926","https://openalex.org/W2018507034","https://openalex.org/W2025970479","https://openalex.org/W2027762699","https://openalex.org/W2028897202","https://openalex.org/W2039216956","https://openalex.org/W2049942256","https://openalex.org/W2050135062","https://openalex.org/W2053247639","https://openalex.org/W2053385401","https://openalex.org/W2057299232","https://openalex.org/W2061240200","https://openalex.org/W2077689825","https://openalex.org/W2094223456","https://openalex.org/W2107363389","https://openalex.org/W2114390083","https://openalex.org/W2121289368","https://openalex.org/W2125181296","https://openalex.org/W2132750264","https://openalex.org/W2138155367","https://openalex.org/W2152210952","https://openalex.org/W2154790710","https://openalex.org/W2154999108","https://openalex.org/W2164194457","https://openalex.org/W2246514367","https://openalex.org/W4211085285","https://openalex.org/W4229743141","https://openalex.org/W4242286941","https://openalex.org/W4292890447","https://openalex.org/W4294326454"],"related_works":["https://openalex.org/W1996644818","https://openalex.org/W1965468642","https://openalex.org/W2093500216","https://openalex.org/W2053588008","https://openalex.org/W2916376502","https://openalex.org/W2260452057","https://openalex.org/W3101161779","https://openalex.org/W423371831","https://openalex.org/W2777729175","https://openalex.org/W4295779760"],"abstract_inverted_index":{"Pancreatic":[0],"ductal":[1],"adenocarcinoma":[2],"(PDAC)":[3],"has":[4],"a":[5,58,141,171,208,217],"dismal":[6],"prognosis":[7],"and":[8,30,85,120,181,227,238],"is":[9,14,154],"highly":[10],"chemoresistant.":[11],"Early":[12],"detection":[13],"the":[15,28,61,76,145,150,167,189,221,235,239,243,246],"only":[16],"means":[17],"to":[18,50,74,86,131,140,223,228,251],"impact":[19,252],"long-term":[20],"survival,":[21],"but":[22],"screening":[23,254],"methods":[24,38],"are":[25],"lacking.":[26],"Given":[27,234],"complex":[29,209],"heterogeneous":[31],"nature":[32,241],"of":[33,60,79,118,135,144,149,177,191,200,212,216,242],"pancreatic":[34],"cancer,":[35],"unbiased":[36],"analytical":[37,244],"such":[39],"as":[40,185,187],"metabolomics":[41],"by":[42,156],"nuclear":[43],"magnetic":[44],"resonance":[45],"(NMR)":[46],"spectroscopy":[47,71,198],"show":[48,220],"promise":[49],"identify":[51],"disease-specific":[52],"molecular":[53,210],"fingerprints.":[54],"NMR":[55,70,197],"profiles":[56,90,117,176,203],"constitute":[57],"fingerprint":[59],"biofluid,":[62],"reporting":[63],"quantitatively":[64],"on":[65,194],"all":[66],"detectable":[67],"small":[68],"biomolecules.":[69],"was":[72,128],"applied":[73],"investigate":[75],"urine":[77,115],"metabolome":[78],"PDAC":[80,119],"patients":[81],"(n":[82,97],"=":[83,98,161,164],"33)":[84],"detect":[87],"altered":[88],"metabolic":[89,202],"in":[91,206],"comparison":[92],"with":[93,179],"healthy":[94],"matched":[95],"controls":[96],"54).":[99],"The":[100,147],"spectral":[101,175],"data":[102],"were":[103,112],"analyzed":[104],"using":[105],"multivariate":[106],"statistical":[107,152],"techniques.":[108],"Statistically":[109],"significant":[110],"differences":[111,134],"found":[113],"between":[114,174],"metabolomic":[116],"control":[121],"individuals":[122,178],"(p":[123],"<":[124],"10(-5)).":[125],"Group":[126],"discrimination":[127,190],"possible":[129],"due":[130],"average":[132],"concentration":[133],"several":[136],"metabolite":[137],"signals,":[138],"pointing":[139],"multimolecular":[142],"signature":[143,211],"disease.":[146],"robustness":[148],"determined":[151],"model":[153],"confirmed":[155],"its":[157],"predictive":[158],"performance":[159],"(sensitivity":[160],"75.8%,":[162],"specificity":[163],"90.7%).":[165],"Additionally,":[166],"method":[168,248],"allowed":[169],"for":[170,188],"neat":[172],"separation":[173],"intermediate":[180],"advanced":[182],"pathologic":[183],"staging,":[184],"well":[186],"samples":[192],"based":[193],"tumor":[195,231],"localization.":[196],"analysis":[199,219],"urinary":[201],"proved":[204],"successful":[205],"identifying":[207],"PDAC.":[213],"Furthermore,":[214],"results":[215],"descriptive-level":[218],"possibility":[222],"follow":[224],"disease":[225],"evolution":[226],"carry":[229],"out":[230],"site":[232],"mapping.":[233],"high":[236],"reproducibility":[237],"noninvasive":[240],"procedure,":[245],"described":[247],"bears":[249],"potential":[250],"large-scale":[253],"programs.":[255]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-04T09:36:47.201465","created_date":"2016-06-24T00:00:00"}
