{"id":"https://openalex.org/W1975005333","doi":"https://doi.org/10.1074/jbc.m510871200","title":"Effects of Peripheral Cannabinoid Receptor Ligands on Motility and Polarization in Neutrophil-like HL60 Cells and Human Neutrophils","display_name":"Effects of Peripheral Cannabinoid Receptor Ligands on Motility and Polarization in Neutrophil-like HL60 Cells and Human Neutrophils","publication_year":2006,"publication_date":"2006-03-02","ids":{"openalex":"https://openalex.org/W1975005333","doi":"https://doi.org/10.1074/jbc.m510871200","mag":"1975005333","pmid":"https://pubmed.ncbi.nlm.nih.gov/16513651"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m510871200","doi":"https://doi.org/10.1074/jbc.m510871200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m510871200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m510871200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102233175","display_name":"Rina Kurihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rina Kurihara","raw_affiliation_strings":["Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan","Department of Legal Medicine and Bioethics, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Legal Medicine and Bioethics, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017442070","display_name":"Yumi Tohyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yumi Tohyama","raw_affiliation_strings":["Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108666197","display_name":"Satoshi Matsusaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Matsusaka","raw_affiliation_strings":["Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109246832","display_name":"Hiromu Naruse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromu Naruse","raw_affiliation_strings":["Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067603681","display_name":"Emi Kinoshita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Emi Kinoshita","raw_affiliation_strings":["Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079434539","display_name":"Takayuki Tsujioka","orcid":"https://orcid.org/0000-0002-5293-5436","observed_orcids":["https://orcid.org/0000-0002-5293-5436"]},"institutions":[{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Tsujioka","raw_affiliation_strings":["Department of Laboratory Medicine and Clinical Pathology, Kawasaki Medical School, Kurashiki 701-0192, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Clinical Pathology, Kawasaki Medical School, Kurashiki 701-0192, Japan","institution_ids":["https://openalex.org/I189996419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068547276","display_name":"Yoshinao Katsumata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinao Katsumata","raw_affiliation_strings":["Department of Legal Medicine and Bioethics, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan","Department of Legal Medicine & Bioethics, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Legal Medicine and Bioethics, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Department of Legal Medicine & Bioethics, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063421059","display_name":"Hirohei Yamamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirohei Yamamura","raw_affiliation_strings":["Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017442070"],"corresponding_institution_ids":["https://openalex.org/I65837984"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.2832,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.86585832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"281","issue":"18","first_page":"12908","last_page":"12918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.6579999923706055},{"id":"https://openalex.org/keywords/2-arachidonoylglycerol","display_name":"2-arachidonoylglycerol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.9409999847412109},{"id":"https://openalex.org/keywords/rhoa-rock-signaling-pathway","display_name":"RhoA/ROCK signaling","score":0.7440000176429749},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.7879999876022339},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.6430000066757202},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.9789999723434448},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.8989999890327454},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5090000033378601},{"id":"https://openalex.org/keywords/cannabinoid-ligands","display_name":"cannabinoid ligands","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.8349864482879639},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6280701756477356},{"id":"https://openalex.org/C2778903051","wikidata":"https://www.wikidata.org/wiki/Q5630035","display_name":"HL60","level":3,"score":0.5699840188026428},{"id":"https://openalex.org/C93248783","wikidata":"https://www.wikidata.org/wiki/Q21150595","display_name":"Cannabinoid receptor type 2","level":5,"score":0.523735761642456},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.45904698967933655},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.41561323404312134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4138294458389282},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.3915802240371704},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36599934101104736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33238959312438965},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22135761380195618},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20725375413894653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11572235822677612},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.06560781598091125}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005989","descriptor_name":"Glycerides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018375","descriptor_name":"Neutrophil Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D043882","descriptor_name":"Receptors, Cannabinoid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m510871200","doi":"https://doi.org/10.1074/jbc.m510871200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m510871200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16513651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16513651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m510871200","doi":"https://doi.org/10.1074/jbc.m510871200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m510871200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1534090153","https://openalex.org/W1928931031","https://openalex.org/W1948361600","https://openalex.org/W1965658250","https://openalex.org/W1972403397","https://openalex.org/W1974642601","https://openalex.org/W1984374880","https://openalex.org/W1986977217","https://openalex.org/W1988650452","https://openalex.org/W1996479070","https://openalex.org/W1997087774","https://openalex.org/W1997247528","https://openalex.org/W1999203299","https://openalex.org/W2001098763","https://openalex.org/W2009996200","https://openalex.org/W2016893884","https://openalex.org/W2024653583","https://openalex.org/W2042209974","https://openalex.org/W2047276626","https://openalex.org/W2056188558","https://openalex.org/W2056993290","https://openalex.org/W2061306380","https://openalex.org/W2062721189","https://openalex.org/W2067577192","https://openalex.org/W2067917704","https://openalex.org/W2072225171","https://openalex.org/W2075171154","https://openalex.org/W2075894678","https://openalex.org/W2077834462","https://openalex.org/W2079581773","https://openalex.org/W2085741941","https://openalex.org/W2107845315","https://openalex.org/W2120082974","https://openalex.org/W2124016864","https://openalex.org/W2130172628","https://openalex.org/W2141083396","https://openalex.org/W2146904199","https://openalex.org/W2148917959","https://openalex.org/W2151519283","https://openalex.org/W2153841101","https://openalex.org/W2154909933","https://openalex.org/W2155505897"],"related_works":["https://openalex.org/W2139870433","https://openalex.org/W1551888116","https://openalex.org/W2917639768","https://openalex.org/W2059960512","https://openalex.org/W7216399656","https://openalex.org/W7051923702","https://openalex.org/W2154909933","https://openalex.org/W2974353717","https://openalex.org/W7171984376","https://openalex.org/W2045987495"],"abstract_inverted_index":{"The":[0],"possible":[1],"role":[2,169],"of":[3,34,56,81,91,110,125,142],"the":[4,57,92],"peripheral":[5],"cannabinoid":[6],"receptor":[7],"(CB2)":[8],"in":[9,77,96,170],"neutrophil":[10,181],"migration":[11,153],"was":[12,47],"investigated":[13],"by":[14,49,87,175],"using":[15],"human":[16,25,45,129],"promyelocytic":[17],"HL60":[18,37,41,65],"cells":[19,23,66,111],"differentiated":[20],"into":[21],"neutrophil-like":[22,40,64],"and":[24,43,61,69,104,152,154],"neutrophils":[26,46,143],"isolated":[27],"from":[28],"whole":[29],"blood.":[30],"Cell":[31],"surface":[32],"expression":[33],"CB2":[35,58,99,165],"on":[36,39,44],"cells,":[38,42],"confirmed":[48],"flow":[50],"cytometry.":[51],"Upon":[52],"stimulation":[53],"with":[54,112,144],"either":[55],"ligands":[59,146],"JWH015":[60,132],"2-arachidonoylglycerol":[62],"(2-AG),":[63],"rapidly":[67],"extended":[68],"retracted":[70],"one":[71],"or":[72,137],"more":[73],"pseudopods":[74],"containing":[75],"F-actin":[76],"different":[78],"directions":[79],"instead":[80],"developing":[82],"front/rear":[83,150],"polarity":[84],"typically":[85],"exhibited":[86],"migrating":[88],"leukocytes.":[89],"Activity":[90],"Rho-GTPase":[93],"RhoA":[94,159,177],"decreased":[95],"response":[97,174],"to":[98,123],"stimulation,":[100],"whereas":[101],"Rac1,":[102],"Rac2,":[103],"Cdc42":[105],"activity":[106],"increased.":[107],"Moreover,":[108],"treatment":[109],"RhoA-dependent":[113],"protein":[114],"kinase":[115],"(p160-ROCK)":[116],"inhibitor":[117],"Y27632":[118],"yielded":[119],"cytoskeletal":[120],"organization":[121],"similar":[122],"that":[124,164],"CB2-stimulated":[126],"cells.":[127],"In":[128],"neutrophils,":[130],"neither":[131],"nor":[133],"2-AG":[134],"induced":[135],"motility":[136],"morphologic":[138],"alterations.":[139],"However,":[140],"pretreatment":[141],"these":[145],"disrupted":[147],"N-formyl-L-methionyl-L-leucyl-L-phenylalanine":[148],"(fMLP)-induced":[149],"polarization":[151],"also":[155],"substantially":[156],"suppressed":[157],"fMLP-induced":[158],"activity.":[160],"These":[161],"results":[162],"suggest":[163],"might":[166],"play":[167],"a":[168],"regulating":[171],"excessive":[172],"inflammatory":[173],"controlling":[176],"activation,":[178],"thereby":[179],"suppressing":[180],"migration.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}