{"id":"https://openalex.org/W1974997331","doi":"https://doi.org/10.1126/science.1857984","title":"A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo Locus","display_name":"A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo Locus","publication_year":1991,"publication_date":"1991-08-02","ids":{"openalex":"https://openalex.org/W1974997331","doi":"https://doi.org/10.1126/science.1857984","mag":"1974997331","pmid":"https://pubmed.ncbi.nlm.nih.gov/1857984"},"language":"en","primary_location":{"id":"doi:10.1126/science.1857984","doi":"https://doi.org/10.1126/science.1857984","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1857984","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1974997331"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027176746","display_name":"Nigel S. Atkinson","orcid":"https://orcid.org/0000-0001-8963-7478","observed_orcids":["https://orcid.org/0000-0001-8963-7478"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigel S. Atkinson","raw_affiliation_strings":["Laboratory of Genetics, University of Wisconsin, Madison, WI 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, University of Wisconsin, Madison, WI 53706","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025873690","display_name":"Gail A. Robertson","orcid":"https://orcid.org/0000-0003-4694-5790","observed_orcids":["https://orcid.org/0000-0003-4694-5790"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gail A. Robertson","raw_affiliation_strings":["Laboratory of Genetics, University of Wisconsin, Madison, WI 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, University of Wisconsin, Madison, WI 53706","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007225561","display_name":"Barry Ganetzky","orcid":"https://orcid.org/0000-0001-5418-7577","observed_orcids":["https://orcid.org/0000-0001-5418-7577"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry Ganetzky","raw_affiliation_strings":["Laboratory of Genetics, University of Wisconsin, Madison, WI 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, University of Wisconsin, Madison, WI 53706","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":8.1732,"has_fulltext":false,"cited_by_count":633,"citation_normalized_percentile":{"value":0.98572867,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"253","issue":"5019","first_page":"551","last_page":"555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-activated-potassium-channels","display_name":"calcium-activated potassium channels","score":0.9929999709129333},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8939999938011169},{"id":"https://openalex.org/keywords/potassium-channel-structure","display_name":"potassium channel structure","score":0.6690000295639038},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.667913019657135},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6589457988739014},{"id":"https://openalex.org/C149614440","wikidata":"https://www.wikidata.org/wiki/Q5018801","display_name":"Calcium-activated potassium channel","level":3,"score":0.5687016844749451},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5045257806777954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4923502206802368},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4918070137500763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49105167388916016},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.4519209861755371},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.43682026863098145},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.41472962498664856},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3952408730983734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38395416736602783},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38023921847343445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3297629952430725},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1857984","doi":"https://doi.org/10.1126/science.1857984","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1857984","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:1857984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1857984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6191860158","display_name":"Neurogenetics of TS-Paralytic Mutants in Drosophila","funder_award_id":"R01NS015390","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6337526742","display_name":"POSTDOCTORAL TRAINING PROGRAM IN MEDICAL GENETICS","funder_award_id":"T32GM007131","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W166358246","https://openalex.org/W1490238718","https://openalex.org/W1559513285","https://openalex.org/W1561725912","https://openalex.org/W1563725780","https://openalex.org/W1947481567","https://openalex.org/W1964692954","https://openalex.org/W1965051773","https://openalex.org/W1967297467","https://openalex.org/W1970087350","https://openalex.org/W1971965814","https://openalex.org/W1972882396","https://openalex.org/W1974442891","https://openalex.org/W1975304761","https://openalex.org/W1977912923","https://openalex.org/W1991587314","https://openalex.org/W1996437700","https://openalex.org/W2002760575","https://openalex.org/W2003234320","https://openalex.org/W2004932985","https://openalex.org/W2006192148","https://openalex.org/W2009310436","https://openalex.org/W2011921542","https://openalex.org/W2019562175","https://openalex.org/W2022236187","https://openalex.org/W2024358879","https://openalex.org/W2025884619","https://openalex.org/W2027351968","https://openalex.org/W2031017369","https://openalex.org/W2042332635","https://openalex.org/W2044157650","https://openalex.org/W2044648543","https://openalex.org/W2050357864","https://openalex.org/W2051374514","https://openalex.org/W2062024310","https://openalex.org/W2062963816","https://openalex.org/W2063362197","https://openalex.org/W2070449043","https://openalex.org/W2079353889","https://openalex.org/W2082304034","https://openalex.org/W2094362927","https://openalex.org/W2094882917","https://openalex.org/W2114838789","https://openalex.org/W2138270253","https://openalex.org/W2167111177","https://openalex.org/W2326879084"],"related_works":["https://openalex.org/W2165343740","https://openalex.org/W1964692954","https://openalex.org/W1991587314","https://openalex.org/W147777286","https://openalex.org/W2058612305","https://openalex.org/W1949796519","https://openalex.org/W1971305526","https://openalex.org/W2054371611","https://openalex.org/W4200450377","https://openalex.org/W1991552773"],"abstract_inverted_index":{"Calcium-activated":[0],"potassium":[1],"channels":[2,25],"mediate":[3],"many":[4],"biologically":[5],"important":[6],"functions":[7],"in":[8,15,45,83],"electrically":[9],"excitable":[10],"cells.":[11],"Despite":[12],"recent":[13],"progress":[14],"the":[16,64],"molecular":[17,53],"analysis":[18],"of":[19,37,55,102],"voltage-activated":[20,79],"K+":[21,24,43,80,104],"channels,":[22],"Ca(2+)-activated":[23,42,103],"have":[26],"not":[27],"been":[28],"similarly":[29],"characterized.":[30],"The":[31,71],"Drosophila":[32],"slowpoke":[33],"(slo)":[34],"locus,":[35],"mutations":[36],"which":[38],"specifically":[39],"abolish":[40],"a":[41,99],"current":[44],"muscles":[46],"and":[47,59,69],"neurons,":[48],"provides":[49],"an":[50],"opportunity":[51],"for":[52,90],"characterization":[54],"these":[56,93],"channels.":[57,105],"Genomic":[58],"complementary":[60],"DNA":[61],"clones":[62],"from":[63],"slo":[65,75,97],"locus":[66],"were":[67],"isolated":[68],"sequenced.":[70],"polypeptide":[72],"predicted":[73],"by":[74],"is":[76],"similar":[77],"to":[78,87],"channel":[81],"polypeptides":[82],"discrete":[84],"domains":[85],"known":[86],"be":[88],"essential":[89],"function.":[91],"Thus,":[92],"results":[94],"indicate":[95],"that":[96],"encodes":[98],"structural":[100],"component":[101]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
