{"id":"https://openalex.org/W1974938596","doi":"https://doi.org/10.1089/nat.2010.0270","title":"RNA Aptamer Therapy for Vaso-Occlusion in Sickle Cell Disease","display_name":"RNA Aptamer Therapy for Vaso-Occlusion in Sickle Cell Disease","publication_year":2011,"publication_date":"2011-07-28","ids":{"openalex":"https://openalex.org/W1974938596","doi":"https://doi.org/10.1089/nat.2010.0270","mag":"1974938596","pmid":"https://pubmed.ncbi.nlm.nih.gov/21793788"},"language":"en","primary_location":{"id":"doi:10.1089/nat.2010.0270","doi":"https://doi.org/10.1089/nat.2010.0270","is_oa":false,"landing_page_url":"https://doi.org/10.1089/nat.2010.0270","pdf_url":null,"source":{"id":"https://openalex.org/S2489440031","display_name":"Nucleic Acid Therapeutics","issn_l":"2159-3337","issn":["2159-3337","2159-3345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acid Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024490090","display_name":"Angela D. Burnette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela D. Burnette","raw_affiliation_strings":["Duke University Medical Center","Department of Surgery, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016424099","display_name":"Shahid Mehdi Nimjee","orcid":"https://orcid.org/0000-0002-0317-8731","observed_orcids":["https://orcid.org/0000-0002-0317-8731"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahid M. Nimjee","raw_affiliation_strings":["Duke University Medical Center","Department of Surgery, Duke University Medical Center, Durham, North Carolina","Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024166925","display_name":"Milena Batchvarova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milena Batchvarova","raw_affiliation_strings":["Duke University Medical Center","Department of Medicine, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Medicine, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057831258","display_name":"Rahima Zennadi","orcid":"https://orcid.org/0000-0002-8220-3260","observed_orcids":["https://orcid.org/0000-0002-8220-3260","https://orcid.org/0009-0000-1371-5695"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahima Zennadi","raw_affiliation_strings":["Duke University Medical Center","Department of Medicine, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Medicine, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061155508","display_name":"Marilyn J. Telen","orcid":"https://orcid.org/0000-0003-3809-1780","observed_orcids":["https://orcid.org/0000-0003-3809-1780"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilyn J. Telen","raw_affiliation_strings":["Duke University Medical Center","Department of Medicine, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Medicine, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001384797","display_name":"Jun\u2010ichi Nishimura","orcid":"https://orcid.org/0000-0001-5026-693X","observed_orcids":["https://orcid.org/0000-0001-5026-693X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-Ichi Nishimura","raw_affiliation_strings":["Osaka University Graduate School of Medicine","Osaka University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka University Graduate School of Medicine","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040370918","display_name":"Bruce A. Sullenger","orcid":"https://orcid.org/0000-0002-5113-5541","observed_orcids":["https://orcid.org/0000-0002-5113-5541"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce A. Sullenger","raw_affiliation_strings":["Duke University Medical Center","Department of Surgery, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040370918"],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":0.4848,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.66057401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"4","first_page":"275","last_page":"283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/vessel-occlusion","display_name":"vascular occlusion","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rna-aptamers","display_name":"RNA aptamers","score":0.9319999814033508},{"id":"https://openalex.org/keywords/alpha-v-beta3-integrin","display_name":"alpha v beta 3 integrin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion-molecules","display_name":"endothelial adhesion molecules","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anti-adhesion-therapy","display_name":"anti-adhesion therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.5649999976158142},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.5889999866485596},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.7876105308532715},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.6071396470069885},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5685367584228516},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5166509747505188},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.5042110681533813},{"id":"https://openalex.org/C199616788","wikidata":"https://www.wikidata.org/wiki/Q4037752","display_name":"E-selectin","level":4,"score":0.4992959499359131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4929783344268799},{"id":"https://openalex.org/C56701166","wikidata":"https://www.wikidata.org/wiki/Q4046137","display_name":"P-selectin","level":4,"score":0.4730186462402344},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4666431248188019},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4463709890842438},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.42564207315444946},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40289607644081116},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4005231261253357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37095457315444946},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.365200400352478},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.24726691842079163},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23485448956489563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2319728434085846},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17967388033866882},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.17852696776390076},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/nat.2010.0270","doi":"https://doi.org/10.1089/nat.2010.0270","is_oa":false,"landing_page_url":"https://doi.org/10.1089/nat.2010.0270","pdf_url":null,"source":{"id":"https://openalex.org/S2489440031","display_name":"Nucleic Acid Therapeutics","issn_l":"2159-3337","issn":["2159-3337","2159-3345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acid Therapeutics","raw_type":"journal-article"},{"id":"pmid:21793788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21793788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acid therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W112228931","https://openalex.org/W176130659","https://openalex.org/W206904905","https://openalex.org/W1502078581","https://openalex.org/W1544230351","https://openalex.org/W1566635406","https://openalex.org/W1834731714","https://openalex.org/W1925247341","https://openalex.org/W1966430815","https://openalex.org/W1968258743","https://openalex.org/W1972380844","https://openalex.org/W1974622319","https://openalex.org/W1978734238","https://openalex.org/W1983051193","https://openalex.org/W1991043791","https://openalex.org/W1992525172","https://openalex.org/W2007991131","https://openalex.org/W2010860495","https://openalex.org/W2014870509","https://openalex.org/W2023388917","https://openalex.org/W2036715058","https://openalex.org/W2041887649","https://openalex.org/W2051138310","https://openalex.org/W2069755913","https://openalex.org/W2079321730","https://openalex.org/W2084621368","https://openalex.org/W2087025337","https://openalex.org/W2090407648","https://openalex.org/W2095001699","https://openalex.org/W2103311193","https://openalex.org/W2104525153","https://openalex.org/W2118818502","https://openalex.org/W2151649268","https://openalex.org/W2157698447","https://openalex.org/W2157735478","https://openalex.org/W2166472438","https://openalex.org/W2409548009","https://openalex.org/W2914437448"],"related_works":["https://openalex.org/W2560660453","https://openalex.org/W2569734796","https://openalex.org/W2002783428","https://openalex.org/W2979427930","https://openalex.org/W4236011952","https://openalex.org/W2094320770","https://openalex.org/W7096323255","https://openalex.org/W2151649268","https://openalex.org/W2157735478","https://openalex.org/W4316813548"],"abstract_inverted_index":{"Patients":[0],"with":[1,100,106,160],"sickle":[2,18],"cell":[3],"disease":[4],"(SCD)":[5],"often":[6],"suffer":[7],"painful":[8],"vaso-occlusive":[9],"episodes":[10],"caused":[11],"in":[12,50,139,169,223],"part":[13],"by":[14,45],"the":[15,22,59,97,121,149,208],"adhesion":[16,30,38,91,142,194,203,216],"of":[17,28,62,75,123,148,165,180,192,211],"erythrocytes":[19],"(SS-RBC)":[20],"to":[21,57,92,96,143,162,187,195,213,218],"vascular":[23],"endothelium.":[24],"To":[25],"investigate":[26],"inhibition":[27],"SS-RBC":[29,68,90,141,193],"as":[31,112,167],"a":[32,72,84,113,189],"possible":[33],"treatment":[34],"for":[35],"vaso-occlusion,":[36],"2":[37,128],"molecules,":[39],"\u03b1(v)\u03b2(3)":[40,63,87,124,134],"and":[41,116],"P-selectin,":[42],"were":[43,69],"targeted":[44],"high-affinity":[46],"RNA":[47],"aptamers.":[48],"An":[49,103],"vitro":[51],"flow":[52],"chamber":[53],"assay":[54],"was":[55,110,154],"used":[56,111],"test":[58],"antiadhesion":[60,184],"activity":[61,147,185],"aptamer":[64,88,104,125,135,151,182],"clone":[65,152],"17.16.":[66],"Human":[67],"passed":[70],"across":[71],"confluent":[73],"monolayer":[74],"thrombin-stimulated":[76],"human":[77],"umbilical":[78],"vein":[79],"endothelial":[80,94,171,215],"cells":[81,95],"(HUVEC)":[82],"at":[83],"constant":[85],"rate.":[86],"reduced":[89],"activated":[93,170],"level":[98],"seen":[99,168],"untreated":[101],"HUVEC.":[102,144],"reactive":[105],"complement":[107],"component":[108],"8":[109],"negative":[114,198],"control":[115,199],"exerted":[117],"no":[118],"inhibition,":[119],"confirming":[120],"specificity":[122],"(P=0.04).":[126],"At":[127,173],"dyn/cm(2)":[129,175],"shear":[130,176],"stress,":[131,177],"30":[132],"nM":[133,179],"showed":[136],"maximal":[137],"effect":[138],"decreasing":[140],"The":[145],"antiadhesive":[146],"P-selectin":[150,166,181],"PF377":[153],"also":[155],"tested":[156],"using":[157],"HUVEC":[158],"pretreated":[159],"IL-13":[161],"upregulate":[163],"expression":[164],"cells.":[172],"1":[174],"60":[178],"had":[183],"similar":[186],"heparin,":[188],"known":[190],"inhibitor":[191],"P-selectin.":[196],"A":[197],"did":[200],"not":[201],"prevent":[202,219],"(P=0.05).":[204],"These":[205],"data":[206],"show":[207],"potential":[209],"utility":[210],"aptamers":[212],"block":[214],"molecules":[217],"or":[220],"treat":[221],"vaso-occlusion":[222],"SCD.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
