{"id":"https://openalex.org/W1974880415","doi":"https://doi.org/10.1159/000169180","title":"Effect of Angiotensin Converting Enzyme Inhibition by Perindopril on Proteinuria of Primary Renal Diseases","display_name":"Effect of Angiotensin Converting Enzyme Inhibition by Perindopril on Proteinuria of Primary Renal Diseases","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1974880415","doi":"https://doi.org/10.1159/000169180","mag":"1974880415","pmid":"https://pubmed.ncbi.nlm.nih.gov/9426847"},"language":"en","primary_location":{"id":"doi:10.1159/000169180","doi":"https://doi.org/10.1159/000169180","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000169180","pdf_url":null,"source":{"id":"https://openalex.org/S106979888","display_name":"American Journal of Nephrology","issn_l":"0250-8095","issn":["0250-8095","1421-9670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113530950","display_name":"Saeid M. Nosrati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saeid M. Nosrati","raw_affiliation_strings":["Division of Nephrology, University of Southern California, School of Medicine, Los Angeles, USA","Division of Nephrology and Department of Medicine, University of Southern California, School of Medicine, Los Angeles, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, University of Southern California, School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Division of Nephrology and Department of Medicine, University of Southern California, School of Medicine, Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013942434","display_name":"Samia Khwaja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samia Khwaja","raw_affiliation_strings":["Division of Nephrology and Department of Medicine, University of Southern California, School of Medicine, Los Angeles, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Department of Medicine, University of Southern California, School of Medicine, Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103797259","display_name":"Mohamed A. El-Shahawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed El-Shahawy","raw_affiliation_strings":["Division of Nephrology and Department of Medicine, University of Southern California, School of Medicine, Los Angeles, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Department of Medicine, University of Southern California, School of Medicine, Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109552712","display_name":"Shaul G. Massry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaul G. Massry","raw_affiliation_strings":["Division of Nephrology and Department of Medicine, University of Southern California, School of Medicine, Los Angeles, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Department of Medicine, University of Southern California, School of Medicine, Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":1.6529,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.8215198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"6","first_page":"511","last_page":"517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perindopril","display_name":"perindopril","score":1.0},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9980000257492065},{"id":"https://openalex.org/keywords/primary-glomerular-disease","display_name":"primary glomerular disease","score":0.746999979019165},{"id":"https://openalex.org/keywords/membranous-nephropathy","display_name":"membranous nephropathy","score":0.9710000157356262},{"id":"https://openalex.org/keywords/membranoproliferative-glomerulonephritis","display_name":"membranoproliferative glomerulonephritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/focal-segmental-glomerulosclerosis","display_name":"focal segmental glomerulosclerosis","score":1.0},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.765999972820282},{"id":"https://openalex.org/keywords/sodium-intake","display_name":"sodium intake","score":0.5519999861717224},{"id":"https://openalex.org/keywords/long-term-drug-efficacy","display_name":"long-term drug efficacy","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2779200603","wikidata":"https://www.wikidata.org/wiki/Q277785","display_name":"Perindopril","level":3,"score":0.9573702812194824},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.8464970588684082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8145406246185303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6766770482063293},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6072174310684204},{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.5141199231147766},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.5047413110733032},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.49428224563598633},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.4914196729660034},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.44519785046577454},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.40864336490631104},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.300336629152298},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.27288204431533813}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020913","descriptor_name":"Perindopril","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000169180","doi":"https://doi.org/10.1159/000169180","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000169180","pdf_url":null,"source":{"id":"https://openalex.org/S106979888","display_name":"American Journal of Nephrology","issn_l":"0250-8095","issn":["0250-8095","1421-9670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Nephrology","raw_type":"journal-article"},{"id":"pmid:9426847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9426847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of nephrology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2054019004","https://openalex.org/W2188877950","https://openalex.org/W2031410978","https://openalex.org/W2077931945","https://openalex.org/W2055757197","https://openalex.org/W2340220858","https://openalex.org/W2090526184","https://openalex.org/W2002616791","https://openalex.org/W2067744739","https://openalex.org/W2019770143"],"abstract_inverted_index":{"Many":[0],"primary":[1,207],"renal":[2,208],"diseases":[3],"are":[4],"associated":[5],"with":[6,15,67,87,158,176],"marked":[7],"proteinuria":[8,23,64,155,205],"resistant":[9],"to":[10,52,71,100,137,217],"immunosuppressive":[11],"therapy.":[12],"Short-term":[13],"treatment":[14,157,175,203],"angiotensin":[16],"converting":[17],"enzyme":[18],"(ACE)":[19],"inhibitors":[20],"may":[21],"decrease":[22,91],"in":[24,62,65,92,109,139,166,172,201],"these":[25,32],"patients,":[26],"but":[27],"the":[28,54,57,84,114,133,152,167,174,202,211,221,224,238],"long-term":[29],"effect":[30,212],"of":[31,48,56,83,144,154,204,206,223,232,240],"agents":[33],"on":[34,237],"urinary":[35,93,148,183],"protein":[36,94,117,184],"excretion":[37,95,118,185],"is":[38,197,213,226],"not":[39,126,235],"known.":[40],"We":[41],"conducted":[42],"a":[43,90,107],"double-blind,":[44],"parallel-design,":[45],"placebo-controlled":[46],"study":[47],"1":[49,188],"year":[50],"duration":[51],"evaluate":[53],"efficacy":[55],"new":[58],"ACE":[59],"inhibitor,":[60],"perindopril,":[61],"reducing":[63],"patients":[66,85,171],"nephrotic":[68],"syndrome":[69],"due":[70],"histologically":[72],"proven":[73],"membranous":[74],"and":[75,78,106,121,135,228],"membranoproliferative":[76],"glomerulonephritis":[77],"focal":[79],"segmental":[80],"glomerulosclerosis.":[81],"Half":[82],"treated":[86],"perindopril":[88,138,159,177,233],"displayed":[89],"from":[96],"6.1":[97],"+/-":[98,102],"1.0":[99],"1.2":[101],"0.5":[103],"g/24":[104,189],"h,":[105],"rise":[108],"serum":[110,122],"albumin":[111,123],"levels.":[112],"In":[113,169],"placebo":[115],"group,":[116],"increased":[119],"modestly":[120],"level":[124,143,239],"did":[125],"change.":[127],"There":[128],"was":[129,160,178],"no":[130],"difference":[131],"between":[132],"responders":[134],"nonresponders":[136],"age,":[140],"blood":[141],"pressure,":[142],"creatinine":[145],"clearance":[146],"or":[147],"sodium":[149,241],"excretion.":[150],"However,":[151],"degree":[153],"before":[156],"significantly":[161],"(p":[162],"<":[163],"0.01)":[164],"higher":[165],"nonresponders.":[168],"3":[170],"whom":[173],"extended":[179],"for":[180,215],"18-24":[181],"months,":[182],"remained":[186],"below":[187],"h.":[190],"The":[191],"data":[192],"show":[193],"that":[194],"perindopril:":[195],"(1)":[196],"an":[198],"effective":[199],"agent":[200],"diseases;":[209],"(2)":[210],"sustained":[214],"up":[216],"2":[218],"years":[219],"if":[220],"administration":[222],"drugs":[225],"maintained,":[227],"(3)":[229],"this":[230],"action":[231],"does":[234],"depend":[236],"intake.":[242]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}