{"id":"https://openalex.org/W1974859786","doi":"https://doi.org/10.1002/ijc.10103","title":"Sequence variation and physical state of human papillomavirus type 16 cervical cancer isolates from Australia and New Caledonia","display_name":"Sequence variation and physical state of human papillomavirus type 16 cervical cancer isolates from Australia and New Caledonia","publication_year":2001,"publication_date":"2001-11-08","ids":{"openalex":"https://openalex.org/W1974859786","doi":"https://doi.org/10.1002/ijc.10103","mag":"1974859786","pmid":"https://pubmed.ncbi.nlm.nih.gov/11857370"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.10103","doi":"https://doi.org/10.1002/ijc.10103","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.10103","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090139271","display_name":"Kylie J. Watts","orcid":"https://orcid.org/0000-0002-8072-2745","observed_orcids":["https://orcid.org/0000-0002-8072-2745"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kylie J. Watts","raw_affiliation_strings":["Department of Infectious Diseases, The University of Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112165712","display_name":"Carol H. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Carol H. Thompson","raw_affiliation_strings":["Department of Infectious Diseases, The University of Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108560940","display_name":"Yvonne E. Cossart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yvonne E. Cossart","raw_affiliation_strings":["Department of Infectious Diseases, The University of Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The University of Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111942762","display_name":"Barbara R. Rose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Barbara R. Rose","raw_affiliation_strings":["","Department of Infectious Diseases, The University of Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Infectious Diseases, The University of Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111942762"],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.0128,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.76827897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"97","issue":"6","first_page":"868","last_page":"874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8140000104904175},{"id":"https://openalex.org/keywords/upstream-regulatory-region","display_name":"upstream regulatory region","score":0.984000027179718},{"id":"https://openalex.org/keywords/e6-gene","display_name":"E6 gene","score":0.9679999947547913},{"id":"https://openalex.org/keywords/e2-gene","display_name":"E2 gene","score":0.7739999890327454},{"id":"https://openalex.org/keywords/e4-gene","display_name":"E4 gene","score":0.9729999899864197},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.7570000290870667},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.8709999918937683},{"id":"https://openalex.org/keywords/promoter-activity","display_name":"promoter activity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/european-lineage","display_name":"European lineage","score":0.703000009059906},{"id":"https://openalex.org/keywords/episomal-hpv-dna","display_name":"episomal HPV DNA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/australia","display_name":"Australia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/new-caledonia","display_name":"New Caledonia","score":1.0}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7831048965454102},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7135128974914551},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.613619863986969},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5695812106132507},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5252230167388916},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.4674053490161896},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4657056927680969},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4265485405921936},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3317645192146301},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1598552167415619}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001315","descriptor_name":"Australia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009510","descriptor_name":"New Caledonia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.10103","doi":"https://doi.org/10.1002/ijc.10103","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.10103","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:11857370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11857370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320966","display_name":"University of Sydney","ror":"https://ror.org/0384j8v12"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W79384053","https://openalex.org/W1532895640","https://openalex.org/W1544336828","https://openalex.org/W1569876593","https://openalex.org/W1729854193","https://openalex.org/W1733587399","https://openalex.org/W1761353211","https://openalex.org/W1850391599","https://openalex.org/W1975304761","https://openalex.org/W1993680169","https://openalex.org/W1994568706","https://openalex.org/W2012233919","https://openalex.org/W2022305813","https://openalex.org/W2027207858","https://openalex.org/W2040364334","https://openalex.org/W2078002983","https://openalex.org/W2078123210","https://openalex.org/W2091314934","https://openalex.org/W2096656229","https://openalex.org/W2102536992","https://openalex.org/W2104459561","https://openalex.org/W2111795354","https://openalex.org/W2128033547","https://openalex.org/W2128678544","https://openalex.org/W2128863601","https://openalex.org/W2138157062","https://openalex.org/W2140998261","https://openalex.org/W2152202163","https://openalex.org/W2170726298","https://openalex.org/W2185553853","https://openalex.org/W2274718148","https://openalex.org/W2418525534","https://openalex.org/W4213345189"],"related_works":["https://openalex.org/W7038833365","https://openalex.org/W2608995180","https://openalex.org/W2170726298","https://openalex.org/W2007891388","https://openalex.org/W2046888692","https://openalex.org/W2076023217","https://openalex.org/W2123120169","https://openalex.org/W2185553853","https://openalex.org/W2123797209","https://openalex.org/W2163352759"],"abstract_inverted_index":{"Sequence":[0],"diversity":[1],"over":[2],"2600":[3],"nucleotides":[4],"of":[5,17,51,62,80,98,142,159,176,199,215,220],"the":[6,12,48,58,63,72,81,85,103,127,137,143,202,216],"upstream":[7],"regulatory":[8],"region":[9],"(URR)":[10],"and":[11,14,27,40,92,130,147,167,189,193,223],"E6":[13,104,146,204],"E2/E4":[15,206],"genes":[16,207],"34":[18],"human":[19],"papillomavirus":[20],"(HPV)16":[21],"cervical":[22],"cancer":[23],"isolates":[24,101,114,178],"from":[25],"Australia":[26],"New":[28],"Caledonia":[29],"was":[30,106,162],"investigated.":[31],"One":[32],"81":[33],"base":[34,38,43],"duplication,":[35],"41":[36],"single":[37,42],"substitutions":[39,125,135],"1":[41],"insertion":[44],"were":[45,90,95],"identified":[46],"in":[47,126,136,145,201,228],"URRs.":[49],"Some":[50,141],"these":[52],"changes":[53,65,144],"are":[54],"reported":[55],"here":[56],"for":[57,169],"first":[59],"time.":[60],"Several":[61],"19":[64],"impacting":[66],"transcription":[67],"factor":[68],"binding":[69],"sites":[70],"had":[71],"potential":[73],"to":[74,84],"alter":[75,150],"promoter":[76],"activity.":[77],"Twenty-eight":[78],"(82%)":[79],"variants":[82],"belonged":[83],"European":[86],"lineage,":[87],"4":[88,190],"(12%)":[89],"Asian":[91],"2":[93],"(6%)":[94],"Asian-American.":[96],"Eighteen":[97],"27":[99],"(67%)":[100],"where":[102],"gene":[105],"examined":[107],"contained":[108,122,179],"amino":[109,123,133],"acid":[110,124,134],"substitutions.":[111],"Of":[112],"13":[113],"sequenced":[115],"with":[116],"intact":[117,171],"E2":[118,128,148,172],"genes,":[119],"12":[120],"(92%)":[121],"protein":[129,154],"3":[131],"(23%)":[132],"overlapping":[138],"E4":[139],"protein.":[140],"may":[149],"immunological":[151],"epitopes":[152],"or":[153,205],"function.":[155],"The":[156],"physical":[157,209],"state":[158],"HPV":[160,182,187],"DNA":[161,188],"assessed":[163],"by":[164],"Southern":[165],"hybridization":[166],"PCR":[168],"an":[170,225],"gene.":[173],"Overall,":[174],"11":[175],"25":[177],"only":[180,185],"integrated":[181,192],"DNA,":[183],"10":[184],"episomal":[186,194],"both":[191],"DNA.":[195],"No":[196],"particular":[197],"patterns":[198],"variation":[200],"URR,":[203],"predicted":[208],"state.":[210],"This":[211],"investigation":[212],"represents":[213],"one":[214],"most":[217],"comprehensive":[218],"studies":[219],"its":[221],"kind":[222],"fills":[224],"important":[226],"gap":[227],"global":[229],"sequence":[230],"data.":[231]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
