{"id":"https://openalex.org/W1974817449","doi":"https://doi.org/10.1002/jmv.1890370112","title":"Efficacy of (S)\u20101\u2010(3\u2010hydroxy\u20102\u2010phosphonylmethoxypropyl)cytosine and 9\u2010(1,3\u2010dihydroxy\u20102\u2010propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice","display_name":"Efficacy of (S)\u20101\u2010(3\u2010hydroxy\u20102\u2010phosphonylmethoxypropyl)cytosine and 9\u2010(1,3\u2010dihydroxy\u20102\u2010propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W1974817449","doi":"https://doi.org/10.1002/jmv.1890370112","mag":"1974817449","pmid":"https://pubmed.ncbi.nlm.nih.gov/1320099"},"language":"en","primary_location":{"id":"doi:10.1002/jmv.1890370112","doi":"https://doi.org/10.1002/jmv.1890370112","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.1890370112","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan Neyts","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038319371","display_name":"Jan M. Balzarini","orcid":"https://orcid.org/0000-0003-2240-3321","observed_orcids":["https://orcid.org/0000-0003-2240-3321","https://orcid.org/0000-0003-1144-1808"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Balzarini","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081640914","display_name":"Lieve M. J. Naesens","orcid":"https://orcid.org/0000-0001-9742-9302","observed_orcids":["https://orcid.org/0000-0001-9742-9302"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lieve Naesens","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040662398","display_name":"Erik De Clercq","orcid":"https://orcid.org/0000-0002-2985-8890","observed_orcids":["https://orcid.org/0000-0002-2985-8890"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Erik de Clercq","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium","Rega Institute for Medical Research, Minderbroedersstraat 10, B\u20103000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research, Minderbroedersstraat 10, B\u20103000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040662398"],"corresponding_institution_ids":["https://openalex.org/I24156275"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":7.3866,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.97483172,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"37","issue":"1","first_page":"67","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/murine-cytomegalovirus","display_name":"murine cytomegalovirus","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cidofovir","display_name":"cidofovir","score":0.8149999976158142},{"id":"https://openalex.org/keywords/ganciclovir","display_name":"ganciclovir","score":0.9610000252723694},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.921999990940094},{"id":"https://openalex.org/keywords/cachexia","display_name":"cachexia","score":0.6439999938011169},{"id":"https://openalex.org/keywords/viral-mortality","display_name":"viral mortality","score":0.4259999990463257},{"id":"https://openalex.org/keywords/antiviral-efficacy","display_name":"antiviral efficacy","score":0.5680000185966492},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2777965375","wikidata":"https://www.wikidata.org/wiki/Q417640","display_name":"Ganciclovir","level":4,"score":0.8319622278213501},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6823025345802307},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.5521652698516846},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.5195372700691223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5128276944160461},{"id":"https://openalex.org/C2777662283","wikidata":"https://www.wikidata.org/wiki/Q747711","display_name":"Betaherpesvirinae","level":5,"score":0.495658278465271},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.45749717950820923},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.45453599095344543},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3724517226219177},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.37061285972595215},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.3515951931476593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3363272249698639},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.33218133449554443},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.05816715955734253},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077404","descriptor_name":"Cidofovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jmv.1890370112","doi":"https://doi.org/10.1002/jmv.1890370112","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.1890370112","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"pmid:1320099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1320099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W921473022","https://openalex.org/W1969718963","https://openalex.org/W1972241043","https://openalex.org/W1977524040","https://openalex.org/W1989877475","https://openalex.org/W1999436929","https://openalex.org/W1999493161","https://openalex.org/W1999881113","https://openalex.org/W2005069966","https://openalex.org/W2008536957","https://openalex.org/W2008890062","https://openalex.org/W2015772291","https://openalex.org/W2017754417","https://openalex.org/W2021453978","https://openalex.org/W2021471955","https://openalex.org/W2030245199","https://openalex.org/W2055103748","https://openalex.org/W2059286898","https://openalex.org/W2074515425","https://openalex.org/W2078044936","https://openalex.org/W2081095625","https://openalex.org/W2090540494","https://openalex.org/W2092984137","https://openalex.org/W2106371912","https://openalex.org/W2131230225","https://openalex.org/W2137194097","https://openalex.org/W2139688506","https://openalex.org/W2167571220","https://openalex.org/W2168902103","https://openalex.org/W2332019209","https://openalex.org/W2410407863","https://openalex.org/W2466576612","https://openalex.org/W2468458865","https://openalex.org/W4242511899"],"related_works":["https://openalex.org/W2050343790","https://openalex.org/W2059184954","https://openalex.org/W4234304829","https://openalex.org/W2139688506","https://openalex.org/W2084684899","https://openalex.org/W4256099262","https://openalex.org/W2084928636","https://openalex.org/W2070563535","https://openalex.org/W2055103748","https://openalex.org/W1998899566"],"abstract_inverted_index":{"Mice":[0],"with":[1,8],"severe":[2],"combined":[3],"immunodeficiency":[4],"(SCID)":[5],"inoculated":[6],"intraperitoneally":[7],"murine":[9],"cytomegalovirus":[10],"(MCMV)":[11],"develop":[12],"a":[13,96],"wasting":[14],"syndrome":[15],"at":[16,21],"3-4":[17],"days":[18,23,59,71,84],"and":[19,30,41,89,117],"die":[20],"6-9":[22],"after":[24,76,92],"the":[25,53,62,77,112,115,119,122],"infection.":[26],"9-(1,3-Dihydroxy-2-propoxymethyl)guanine":[27],"(DHPG,":[28],"ganciclovir)":[29],"(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine":[31],"(HPMPC)":[32],"were":[33],"compared":[34],"for":[35,56,68],"their":[36],"efficacy":[37],"against":[38],"MCMV-induced":[39],"disease":[40,116],"mortality":[42],"in":[43,110],"SCID":[44],"mice.":[45,124],"Under":[46],"all":[47],"treatment":[48],"conditions,":[49],"i.e.,":[50],"administration":[51],"of":[52,64,81,114,121],"test":[54],"compounds":[55],"5":[57,69],"consecutive":[58,70,83],"starting":[60,72,85],"on":[61,73,86,99],"day":[63,74,87,90,100],"infection":[65],"(day":[66],"0),":[67],"4":[75],"infection,":[78,93,103],"2":[79],"periods":[80],"3":[82,101],"0":[88],"9":[91],"or":[94],"as":[95],"single":[97],"dose":[98],"before":[102],"HPMPC":[104],"proved":[105],"far":[106],"superior":[107],"to":[108],"ganciclovir":[109],"delaying":[111],"onset":[113],"increasing":[118],"lifespan":[120],"MCMV-infected":[123]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}