{"id":"https://openalex.org/W1974789691","doi":"https://doi.org/10.3892/or.2013.2796","title":"Combination of the FGFR4 inhibitor PD173074 and 5-fluorouracil reduces proliferation and promotes apoptosis in gastric cancer","display_name":"Combination of the FGFR4 inhibitor PD173074 and 5-fluorouracil reduces proliferation and promotes apoptosis in gastric cancer","publication_year":2013,"publication_date":"2013-10-11","ids":{"openalex":"https://openalex.org/W1974789691","doi":"https://doi.org/10.3892/or.2013.2796","mag":"1974789691","pmid":"https://pubmed.ncbi.nlm.nih.gov/24126887"},"language":"en","primary_location":{"id":"doi:10.3892/or.2013.2796","doi":"https://doi.org/10.3892/or.2013.2796","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2013.2796","pdf_url":"http://www.spandidos-publications.com/or/30/6/2777/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/or/30/6/2777/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110137928","display_name":"Yan\u2010Wei Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YAN-WEI YE","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100681736","display_name":"Shuang Hu","orcid":"https://orcid.org/0000-0003-0310-9418","observed_orcids":["https://orcid.org/0000-0003-0310-9418"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"SHUANG HU","raw_affiliation_strings":["Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","[Zhengzhou University.]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"[Zhengzhou University.]","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112073467","display_name":"Ying-Qiang Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YING-QIANG SHI","raw_affiliation_strings":["Department of Stomach and Soft Tissue Sarcoma Surgery, Shanghai Cancer Center, Fu Dan University, Shanghai, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomach and Soft Tissue Sarcoma Surgery, Shanghai Cancer Center, Fu Dan University, Shanghai, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025642259","display_name":"XIE-FU ZHANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIE-FU ZHANG","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","[Zhengzhou University.]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"[Zhengzhou University.]","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025363930","display_name":"Ye Zhou","orcid":"https://orcid.org/0000-0002-8780-0099","observed_orcids":["https://orcid.org/0000-0002-8780-0099"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YE ZHOU","raw_affiliation_strings":["Department of Stomach and Soft Tissue Sarcoma Surgery, Shanghai Cancer Center, Fu Dan University, Shanghai, P.R. China","Fudan University Shanghai Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomach and Soft Tissue Sarcoma Surgery, Shanghai Cancer Center, Fu Dan University, Shanghai, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102079117","display_name":"Chun-Lin Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHUN-LIN ZHAO","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","[Zhengzhou University.]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"[Zhengzhou University.]","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":null,"display_name":"GUO-JUN WANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"GUO-JUN WANG","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","[Zhengzhou University.]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"[Zhengzhou University.]","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100641777","display_name":"Jianguo Wen","orcid":"https://orcid.org/0000-0003-0952-118X","observed_orcids":["https://orcid.org/0000-0003-0952-118X","https://orcid.org/0000-0002-1574-6812"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JIAN-GUO WEN","raw_affiliation_strings":["Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","[Zhengzhou University.]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"[Zhengzhou University.]","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038349203","display_name":"Hong Zong","orcid":"https://orcid.org/0000-0002-7731-1822","observed_orcids":["https://orcid.org/0000-0002-7731-1822"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HONG ZONG","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","[Zhengzhou University.]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"[Zhengzhou University.]","institution_ids":["https://openalex.org/I38877650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6411,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.82588578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"6","first_page":"2777","last_page":"2784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/fgfr4","display_name":"FGFR4","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pd173074","display_name":"PD173074","score":0.9950000047683716},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9879999756813049},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mkn45-cells","display_name":"MKN45 cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/fgf19","display_name":"FGF19","score":0.8550000190734863},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9890000224113464},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8005335330963135},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7274909019470215},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.7263863682746887},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6231403946876526},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6175518035888672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5491818785667419},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.517850935459137},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5014076232910156},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4994220733642578},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.46500787138938904},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4588722288608551},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.43629857897758484},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.42216426134109497},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35123327374458313},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28299570083618164},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1623326539993286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12418416142463684},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05583164095878601},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051499","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051499","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051499","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.2013.2796","doi":"https://doi.org/10.3892/or.2013.2796","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2013.2796","pdf_url":"http://www.spandidos-publications.com/or/30/6/2777/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:24126887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24126887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2013.2796","doi":"https://doi.org/10.3892/or.2013.2796","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2013.2796","pdf_url":"http://www.spandidos-publications.com/or/30/6/2777/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2761918542","display_name":null,"funder_award_id":"81201955","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322766","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1974789691.pdf","grobid_xml":"https://content.openalex.org/works/W1974789691.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1913097128","https://openalex.org/W1978454134","https://openalex.org/W2008837727","https://openalex.org/W2012769611","https://openalex.org/W2032719221","https://openalex.org/W2033600464","https://openalex.org/W2034198983","https://openalex.org/W2041451676","https://openalex.org/W2042055907","https://openalex.org/W2050453518","https://openalex.org/W2056983875","https://openalex.org/W2063283864","https://openalex.org/W2074775218","https://openalex.org/W2078058991","https://openalex.org/W2083880396","https://openalex.org/W2131597845","https://openalex.org/W2132163449","https://openalex.org/W2147893730","https://openalex.org/W2165757793"],"related_works":["https://openalex.org/W2296191529","https://openalex.org/W4414846285","https://openalex.org/W1830180613","https://openalex.org/W2790456193","https://openalex.org/W4205911500","https://openalex.org/W1987095497","https://openalex.org/W4409625167","https://openalex.org/W7149031444","https://openalex.org/W1999180929","https://openalex.org/W2028308255"],"abstract_inverted_index":{"Our":[0],"previous":[1],"findings":[2],"revealed":[3],"that":[4,138,183,252],"FGFR4":[5,139,208,220],"may":[6,209,259],"be":[7,210],"a":[8,27,50,63,71],"novel":[9],"therapeutic":[10],"target":[11],"for":[12],"gastric":[13,40,51,266],"cancer.":[14,267],"The":[15],"aim":[16],"of":[17,26,29,39,65,73,93,110,122,158,176,195,204,207,214,225,228,265],"the":[18,24,36,45,91,100,104,108,115,120,123,129,144,150,155,164,166,170,174,185,193,205,211,223,226,247,253,262],"present":[19],"study":[20],"was":[21,55,87,126,141,180],"to":[22,89,163,243,261],"explore":[23],"effects":[25,224,245],"combination":[28,64,124,175,227,258],"PD173074":[30],"(PD)":[31],"and":[32,44,68,81,96,112,178,197,199,230,237],"5-fluorouracil":[33],"(5-Fu)":[34],"on":[35],"biological":[37],"behavior":[38],"cancer":[41,52],"cell":[42,53,116,239],"lines":[43],"relevant":[46],"mechanisms":[47,213],"involved.":[48],"MKN45,":[49],"line,":[54],"treated":[56,172],"with":[57,149,173],"each":[58],"single":[59,132,188,248],"agent":[60,249],"alone":[61],"or":[62],"FGF19,":[66],"PD":[67,111,152,177,191,215,231],"5-Fu.":[69],"Then,":[70],"series":[72],"functional":[74],"assays":[75],"were":[76,241],"performed":[77],"using":[78],"CCK-8":[79],"assay":[80],"flow":[82],"cytometry.":[83],"Western":[84,134],"blot":[85,135],"analysis":[86,136],"used":[88],"determine":[90],"expression":[92,140,194],"signaling":[94],"pathway":[95],"downstream-related":[97],"molecules":[98],"in":[99,143,169,184,232,257],"MKN45":[101,159],"cells":[102,160,171,186],"following":[103,131,187,246],"different":[105],"treatments.":[106],"As":[107],"concentration":[109],"5-Fu":[113,179,218,229],"increased,":[114],"viability":[117,121,130],"gradually":[118],"decreased;":[119],"group":[125],"less":[127],"than":[128,182],"administration.":[133],"showed":[137],"weak":[142],"5-Fu-treated":[145],"groups":[146],"when":[147,161],"compared":[148,162],"control.":[151],"markedly":[153],"increased":[154,200],"apoptosis":[156,167,236],"rate":[157,168],"control;":[165],"higher":[181],"treatment.":[189],"Furthermore,":[190,222],"reduced":[192,219],"p-ERK":[196],"Bcl-xl":[198],"caspase-3":[201],"expression.":[202,221],"Inhibition":[203],"activity":[206],"main":[212],"effect":[216],"while":[217],"inhibiting":[233],"proliferation,":[234],"increasing":[235],"arresting":[238],"cycle":[240],"superior":[242],"these":[244],"treatments,":[250],"suggesting":[251],"two":[254],"drugs":[255],"applied":[256],"contribute":[260],"effective":[263],"treatment":[264]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}