{"id":"https://openalex.org/W1974732002","doi":"https://doi.org/10.1046/j.1365-2141.1996.00387.x","title":"Early suppressive effects of chemotherapy and cytokine treatment on committed versus primitive haemopoietic progenitors in patient bone marrow","display_name":"Early suppressive effects of chemotherapy and cytokine treatment on committed versus primitive haemopoietic progenitors in patient bone marrow","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W1974732002","doi":"https://doi.org/10.1046/j.1365-2141.1996.00387.x","mag":"1974732002","pmid":"https://pubmed.ncbi.nlm.nih.gov/8616014"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2141.1996.00387.x","doi":"https://doi.org/10.1046/j.1365-2141.1996.00387.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1996.00387.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113501279","display_name":"Gretchen N. Schwartz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G. N. Schwartz","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda, Maryland, USA","Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062706815","display_name":"Frances T. Hakim","orcid":"https://orcid.org/0000-0003-2507-8229","observed_orcids":["https://orcid.org/0000-0003-2507-8229"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Hakim","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108530619","display_name":"J. A. Zujewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Zujewski","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110126420","display_name":"J. M. Szabo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Szabo","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014926475","display_name":"R. Cepada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Cepada","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051763398","display_name":"David A. Riseberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Riseberg","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078086017","display_name":"M. Kim Warren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. K. Warren","raw_affiliation_strings":["Otsuka Pharmaceutical Co., Rockville,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otsuka Pharmaceutical Co., Rockville,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087779758","display_name":"Crystal Lee Mackall","orcid":"https://orcid.org/0000-0003-0359-9023","observed_orcids":["https://orcid.org/0000-0003-0359-9023","https://orcid.org/0000-0001-6323-4304"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. L. Mackall","raw_affiliation_strings":["Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010939155","display_name":"A. Setzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Setzer","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111501011","display_name":"Marianne Noone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Noone","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111997075","display_name":"Kenneth H. Cowan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. H. Cowan","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071432873","display_name":"Joyce O\u2019Shaughnessy","orcid":"https://orcid.org/0000-0002-2955-5523","observed_orcids":["https://orcid.org/0000-0002-2955-5523","https://orcid.org/0000-0001-6764-2807"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. O\u2019Shaughnessy","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066218992","display_name":"Ronald E. Gress","orcid":"https://orcid.org/0000-0001-8259-5332","observed_orcids":["https://orcid.org/0000-0001-8259-5332"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. E. Gress","raw_affiliation_strings":["Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A","Medicine Branch, National Cancer Institute, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, Bethesda,","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113501279"],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.6492,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.67334075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"92","issue":"3","first_page":"537","last_page":"547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.048700001090765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotherapy-induced-myelosuppression","display_name":"chemotherapy-induced myelosuppression","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bone-marrow-injury","display_name":"bone marrow damage","score":0.5170000195503235},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/committed-progenitors","display_name":"committed progenitors","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cfu-gm","display_name":"CFU-GM","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8690000176429749},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.7670000195503235},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.9079999923706055},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer-chemotherapy","display_name":"breast cancer chemotherapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/long-term-culture","display_name":"long-term culture","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7641028165817261},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7436840534210205},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6634935140609741},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6535429358482361},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6318013072013855},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.60178142786026},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.5838550925254822},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5090084075927734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4429793357849121},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.44290074706077576},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42938917875289917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3713541626930237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3200606405735016},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10229110717773438}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2141.1996.00387.x","doi":"https://doi.org/10.1046/j.1365-2141.1996.00387.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1996.00387.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:8616014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8616014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2334151329","https://openalex.org/W2056953039","https://openalex.org/W1994644823","https://openalex.org/W2004127500","https://openalex.org/W2128335526","https://openalex.org/W264750549","https://openalex.org/W142692312","https://openalex.org/W2108338041","https://openalex.org/W2065383384","https://openalex.org/W2416295860"],"abstract_inverted_index":{"These":[0,183],"studies":[1],"investigated":[2],"the":[3,66,129,139,157,199,203],"effectiveness":[4],"of":[5,9,47,68,72,86,131,141,145,156,164,196,202],"in":[6,11,88,99,120,143,159],"vivo":[7],"administration":[8],"cytokines":[10],"ameliorating":[12],"potential":[13],"marrow":[14,89,100,121,147],"damage":[15],"induced":[16],"by":[17,30],"chemotherapy.":[18],"Breast":[19],"cancer":[20],"patients":[21],"received":[22],"5-fluorouracil,":[23],"leucovorin,":[24],"doxorubicin":[25],"and":[26,41,59,84,175],"cyclophosphamide":[27],"(FLAC)":[28],"followed":[29],"either":[31],"GM-CSF,":[32],"PIXY321,":[33],"or":[34,44,104,193],"no":[35],"cytokine.":[36,107],"Marrow":[37],"was":[38,125,153],"obtained":[39,90,101],"before":[40],"after":[42,91,102,114],"one":[43],"two":[45],"cycles":[46],"FLAC":[48,92,105,115,165,197],"once":[49],"blood":[50,79],"cell":[51,80,109],"counts":[52],"had":[53,178],"recovered.":[54],"Colony-forming":[55],"units":[56],"for":[57,77],"granulocytes":[58],"macrophages":[60],"(CFU-GM)":[61],"were":[62,95,111,169],"used":[63,126],"to":[64,127,180],"indicate":[65],"effect":[67,130],"therapy":[69,132],"on":[70,133,166,198],"recovery":[71],"committed":[73,173],"progenitor":[74],"cells":[75,177],"responsible":[76],"early":[78],"recovery.":[81],"The":[82],"frequency":[83],"number":[85,140,158],"CFU-GM":[87,118,142],"+":[93,116],"PIXY321":[94],"significantly":[96],"lower":[97],"than":[98],"FLAC+GM-CSF":[103],"without":[106],"CD34+":[108,176],"numbers":[110],"also":[112],"reduced":[113],"PIXY321.":[117],"production":[119],"long-term":[122],"cultures":[123],"(LTC)":[124],"assess":[128],"primitive":[134,167],"progenitors.":[135],"After":[136],"5":[137],"weeks":[138],"LTC":[144],"post-therapy":[146],"from":[148],"all":[149],"three":[150],"treatment":[151,188],"arms":[152],"<":[154],"15%":[155],"pre-therapy":[160,181],"LTC.":[161],"Suppressive":[162],"effects":[163,195],"progenitors":[168,174],"observed":[170],"even":[171],"when":[172],"recovered":[179],"levels.":[182],"results":[184],"demonstrate":[185],"that":[186],"cytokine":[187],"did":[189],"not":[190],"ameliorate":[191],"suppressive":[192],"toxic":[194],"functional":[200],"integrity":[201],"marrow.":[204]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
