{"id":"https://openalex.org/W1974635192","doi":"https://doi.org/10.1016/0197-4580(80)90018-4","title":"Senescent changes in a neurobiological model system: Cerebellar Purkinje cell electrophysiology and correlative anatomy","display_name":"Senescent changes in a neurobiological model system: Cerebellar Purkinje cell electrophysiology and correlative anatomy","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W1974635192","doi":"https://doi.org/10.1016/0197-4580(80)90018-4","mag":"1974635192","pmid":"https://pubmed.ncbi.nlm.nih.gov/7266732"},"language":"en","primary_location":{"id":"doi:10.1016/0197-4580(80)90018-4","doi":"https://doi.org/10.1016/0197-4580(80)90018-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0197-4580(80)90018-4","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J ROGERS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J ROGERS","raw_affiliation_strings":["The Salk Institute, P.O. Box 85800, San Diego, CA 92138 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, P.O. Box 85800, San Diego, CA 92138 USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M SILVER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M SILVER","raw_affiliation_strings":["The Salk Institute, P.O. Box 85800, San Diego, CA 92138 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, P.O. Box 85800, San Diego, CA 92138 USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109934207","display_name":"William J. Shoemaker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W SHOEMAKER","raw_affiliation_strings":["The Salk Institute, P.O. Box 85800, San Diego, CA 92138 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, P.O. Box 85800, San Diego, CA 92138 USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111390850","display_name":"Floyd E. Bloom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F BLOOM","raw_affiliation_strings":["The Salk Institute, P.O. Box 85800, San Diego, CA 92138 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, P.O. Box 85800, San Diego, CA 92138 USA","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":1.5423,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.79936427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1","issue":"1","first_page":"3","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.16349999606609344,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.09889999777078629,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/purkinje-cells","display_name":"Purkinje cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6510000228881836},{"id":"https://openalex.org/keywords/neuronal-senescence","display_name":"neuronal senescence","score":0.8709999918937683},{"id":"https://openalex.org/keywords/simple-spikes","display_name":"simple spikes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/lipofuscin-accumulation","display_name":"lipofuscin accumulation","score":0.875},{"id":"https://openalex.org/keywords/nissl-staining","display_name":"Nissl staining","score":0.9010000228881836},{"id":"https://openalex.org/keywords/catecholamine-fluorescence","display_name":"catecholamine fluorescence","score":0.7149999737739563},{"id":"https://openalex.org/keywords/glyoxylic-acid","display_name":"glyoxylic acid","score":0.7089999914169312},{"id":"https://openalex.org/keywords/inferior-olive","display_name":"inferior olive","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2776800370","wikidata":"https://www.wikidata.org/wiki/Q5172864","display_name":"Correlative","level":2,"score":0.7747548818588257},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7510254383087158},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.7381925582885742},{"id":"https://openalex.org/C2777463368","wikidata":"https://www.wikidata.org/wiki/Q2014587","display_name":"Purkinje fibers","level":3,"score":0.5442554950714111},{"id":"https://openalex.org/C2778472085","wikidata":"https://www.wikidata.org/wiki/Q1570272","display_name":"Purkinje cell","level":3,"score":0.4860852062702179},{"id":"https://openalex.org/C2992333117","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellar cortex","level":3,"score":0.4847526252269745},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.39820510149002075},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.393955260515213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32873228192329407},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.04601743817329407},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005071","descriptor_name":"Evoked Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005071","descriptor_name":"Evoked Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005071","descriptor_name":"Evoked Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008062","descriptor_name":"Lipofuscin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008062","descriptor_name":"Lipofuscin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008062","descriptor_name":"Lipofuscin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0197-4580(80)90018-4","doi":"https://doi.org/10.1016/0197-4580(80)90018-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0197-4580(80)90018-4","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},{"id":"pmid:7266732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7266732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of aging","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/1"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W231667458","https://openalex.org/W1582681335","https://openalex.org/W1775749144","https://openalex.org/W1982044886","https://openalex.org/W1987368250","https://openalex.org/W2000016530","https://openalex.org/W2011266511","https://openalex.org/W2024260091","https://openalex.org/W2041788443","https://openalex.org/W2049167716","https://openalex.org/W2051874000","https://openalex.org/W2080035729","https://openalex.org/W2089180164","https://openalex.org/W2095234133","https://openalex.org/W2118771966","https://openalex.org/W2185812497","https://openalex.org/W2288386516","https://openalex.org/W2418491902","https://openalex.org/W2475322873","https://openalex.org/W2505712406"],"related_works":["https://openalex.org/W2044374679","https://openalex.org/W1992581884","https://openalex.org/W2068165145","https://openalex.org/W2187863091","https://openalex.org/W4241951680","https://openalex.org/W1982196675","https://openalex.org/W2079862961","https://openalex.org/W2028135093","https://openalex.org/W1975132442","https://openalex.org/W2073159300"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}