{"id":"https://openalex.org/W1974537049","doi":"https://doi.org/10.1053/j.gastro.2011.09.027","title":"Hepatocellular Carcinoma Enters the Sequencing Era","display_name":"Hepatocellular Carcinoma Enters the Sequencing Era","publication_year":2011,"publication_date":"2011-09-30","ids":{"openalex":"https://openalex.org/W1974537049","doi":"https://doi.org/10.1053/j.gastro.2011.09.027","mag":"1974537049","pmid":"https://pubmed.ncbi.nlm.nih.gov/21963842","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3679498"},"language":"en","primary_location":{"id":"doi:10.1053/j.gastro.2011.09.027","doi":"https://doi.org/10.1053/j.gastro.2011.09.027","is_oa":false,"landing_page_url":"https://doi.org/10.1053/j.gastro.2011.09.027","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3679498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059651582","display_name":"Augusto Villanueva","orcid":"https://orcid.org/0000-0003-3585-3727","observed_orcids":["https://orcid.org/0000-0003-3585-3727"]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Augusto Villanueva","raw_affiliation_strings":["HCC Translational Research Laboratory, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas, Institut d'Investigacions Biomediques Agusto Pi i Sunyer, Barcelona, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HCC Translational Research Laboratory, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas, Institut d'Investigacions Biomediques Agusto Pi i Sunyer, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007607351","display_name":"Yujin Hoshida","orcid":"https://orcid.org/0000-0001-9430-1426","observed_orcids":["https://orcid.org/0000-0001-9430-1426"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yujin Hoshida","raw_affiliation_strings":["Cancer Program, Broad Institute, Cambridge, Massachusetts, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts","Broad INstitute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Program, Broad Institute, Cambridge, Massachusetts, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Broad INstitute","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052975894","display_name":"Josep Maria Llovet","orcid":"https://orcid.org/0000-0003-0547-2667","observed_orcids":["https://orcid.org/0000-0003-0547-2667"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Josep M. Llovet","raw_affiliation_strings":["HCC Translational Research Laboratory, Barcelona-Cl\u00ednic Liver Cancer (BCLC) Group, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas, Liver Unit, Institut d'Investigacions Biomediques Agusto Pi i Sunyer, Barcelona, Catalonia, Spain, Liver Cancer Program, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York, Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats, Barcelona, Catalonia, Spain","CSIC - Institute of Biomedical Research of Barcelona","Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HCC Translational Research Laboratory, Barcelona-Cl\u00ednic Liver Cancer (BCLC) Group, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas, Liver Unit, Institut d'Investigacions Biomediques Agusto Pi i Sunyer, Barcelona, Catalonia, Spain, Liver Cancer Program, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York, Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I11932220","https://openalex.org/I4210132431","https://openalex.org/I98704320"]},{"raw_affiliation_string":"CSIC - Institute of Biomedical Research of Barcelona","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":0.3206,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.59436665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"141","issue":"5","first_page":"1943","last_page":"1945"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.14259999990463257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/genome-sequencing","display_name":"genome sequencing","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.781000018119812},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7310000061988831},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.835699200630188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.345395028591156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32997530698776245},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32082507014274597}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1053/j.gastro.2011.09.027","doi":"https://doi.org/10.1053/j.gastro.2011.09.027","is_oa":false,"landing_page_url":"https://doi.org/10.1053/j.gastro.2011.09.027","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:21963842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21963842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Comment"},{"id":"pmh:oai:europepmc.org:2676625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3679498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3679498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3679498","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Gastroenterology","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2676625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3679498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3729548040","display_name":"Integrative genomic analysis in hepatocellular carcinoma","funder_award_id":"R01DK076986","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393065666","https://openalex.org/W2950804217","https://openalex.org/W2074289178","https://openalex.org/W4238166062","https://openalex.org/W2416614966","https://openalex.org/W2471055154","https://openalex.org/W2088558910","https://openalex.org/W4383895226","https://openalex.org/W2998992705","https://openalex.org/W7100499659"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}