{"id":"https://openalex.org/W1974514766","doi":"https://doi.org/10.1111/j.1749-6632.2000.tb07045.x","title":"Cellular and Molecular Responses to Topoisomerase I Poisons: Exploiting Synergy for Improved Radiotherapy","display_name":"Cellular and Molecular Responses to Topoisomerase I Poisons: Exploiting Synergy for Improved Radiotherapy","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1974514766","doi":"https://doi.org/10.1111/j.1749-6632.2000.tb07045.x","mag":"1974514766","pmid":"https://pubmed.ncbi.nlm.nih.gov/11193903"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.2000.tb07045.x","doi":"https://doi.org/10.1111/j.1749-6632.2000.tb07045.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2000.tb07045.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010499089","display_name":"Shigeki Miyamoto","orcid":"https://orcid.org/0000-0002-7827-3426","observed_orcids":["https://orcid.org/0000-0002-7827-3426"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SHIGEKI MIYAMOTO","raw_affiliation_strings":["Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074359093","display_name":"Tony T. Huang","orcid":"https://orcid.org/0000-0001-9291-5002","observed_orcids":["https://orcid.org/0000-0001-9291-5002"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TONY T. HUANG","raw_affiliation_strings":["Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054461565","display_name":"Shelly M. Wuerzberger\u2010Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SHELLY WUERZBERGER\u2010DAVIS","raw_affiliation_strings":["Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA","Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105789795","display_name":"William G. Bornmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WILLIAM G. BORNMANN","raw_affiliation_strings":["Preparative Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preparative Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016353084","display_name":"John J. Pink","orcid":"https://orcid.org/0000-0002-3111-5754","observed_orcids":["https://orcid.org/0000-0002-3111-5754"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN J. PINK","raw_affiliation_strings":["Departments of Radiation Oncology & Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106\u20134942, USA","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiation Oncology & Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106\u20134942, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004940200","display_name":"Colleen Tagliarino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"COLLEEN TAGLIARINO","raw_affiliation_strings":["Departments of Radiation Oncology & Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106\u20134942, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiation Oncology & Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106\u20134942, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108080497","display_name":"Timothy James Kinsella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TIMOTHY J. KINSELLA","raw_affiliation_strings":["Departments of Radiation Oncology & Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106\u20134942, USA","Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiation Oncology & Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106\u20134942, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016606481","display_name":"David A. Boothman","orcid":"https://orcid.org/0000-0001-7474-9020","observed_orcids":["https://orcid.org/0000-0001-7474-9020"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"DAVID A. BOOTHMAN","raw_affiliation_strings":["Departments of Radiation Oncology & Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106\u20134942, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiation Oncology & Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106\u20134942, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016606481"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.2266,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.46623873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"922","issue":"1","first_page":"274","last_page":"292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-i-poisons","display_name":"topoisomerase I poisons","score":0.9049999713897705},{"id":"https://openalex.org/keywords/topotecan","display_name":"topotecan","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7879999876022339},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.753000020980835},{"id":"https://openalex.org/keywords/beta-lapachone","display_name":"\u03b2-lapachone","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6549999713897705},{"id":"https://openalex.org/keywords/anti-apoptotic-factors","display_name":"anti-apoptotic factors","score":0.5960000157356262},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7233554124832153},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6593948602676392},{"id":"https://openalex.org/C2776253266","wikidata":"https://www.wikidata.org/wiki/Q414000","display_name":"Aphidicolin","level":4,"score":0.6067492365837097},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.5411597490310669},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5094771981239319},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.49465224146842957},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4751058518886566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46488118171691895},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4632505178451538},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44885843992233276},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43220147490501404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40488311648368835},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.32900571823120117},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2297375202178955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15703999996185303},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06894853711128235}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.2000.tb07045.x","doi":"https://doi.org/10.1111/j.1749-6632.2000.tb07045.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2000.tb07045.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:11193903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11193903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7396528853","display_name":"DNA MISMATCH REPAIR IN FDURD INDUCED CYTOTOXICITY","funder_award_id":"R01CA083196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7426042845","display_name":"Use of Beta-lapachone for Lung Cancer Chemotherapy","funder_award_id":"R01CA102792","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8685536556","display_name":null,"funder_award_id":"R01-CA85542","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W114449418","https://openalex.org/W159145295","https://openalex.org/W1495106561","https://openalex.org/W1496617320","https://openalex.org/W1507732932","https://openalex.org/W1508092996","https://openalex.org/W1530401629","https://openalex.org/W1531268050","https://openalex.org/W1536830515","https://openalex.org/W1547109494","https://openalex.org/W1549846058","https://openalex.org/W1595724240","https://openalex.org/W1660224085","https://openalex.org/W1776881772","https://openalex.org/W1886968564","https://openalex.org/W1906310597","https://openalex.org/W1969309856","https://openalex.org/W1979520552","https://openalex.org/W1980768491","https://openalex.org/W1988586561","https://openalex.org/W1990283519","https://openalex.org/W1990924496","https://openalex.org/W1991068605","https://openalex.org/W1994854994","https://openalex.org/W1997509253","https://openalex.org/W1998574404","https://openalex.org/W2008569721","https://openalex.org/W2010128263","https://openalex.org/W2016632303","https://openalex.org/W2018007773","https://openalex.org/W2022940390","https://openalex.org/W2028185348","https://openalex.org/W2029276835","https://openalex.org/W2033424777","https://openalex.org/W2037915962","https://openalex.org/W2040470926","https://openalex.org/W2053293707","https://openalex.org/W2061955668","https://openalex.org/W2062490826","https://openalex.org/W2062490989","https://openalex.org/W2064558057","https://openalex.org/W2071754363","https://openalex.org/W2083678005","https://openalex.org/W2085008509","https://openalex.org/W2085062329","https://openalex.org/W2087202363","https://openalex.org/W2091695331","https://openalex.org/W2103012321","https://openalex.org/W2110010650","https://openalex.org/W2114279859","https://openalex.org/W2136887070","https://openalex.org/W2158708535","https://openalex.org/W2159979956","https://openalex.org/W2162232120","https://openalex.org/W2394674068","https://openalex.org/W2421129218","https://openalex.org/W2442488268","https://openalex.org/W4236530034","https://openalex.org/W4299437781"],"related_works":["https://openalex.org/W2103321580","https://openalex.org/W1573954848","https://openalex.org/W2103012321","https://openalex.org/W2071754363","https://openalex.org/W1946967684","https://openalex.org/W7073528893","https://openalex.org/W2022940390","https://openalex.org/W2012619126","https://openalex.org/W3012483614","https://openalex.org/W2103825714"],"abstract_inverted_index":{"The":[0],"efficacy":[1],"of":[2,18,79,82,97,224,247],"topoisomerase":[3],"(Topo)":[4],"I-active":[5,32,205],"drugs":[6,33],"may":[7,116,257],"be":[8,57,361],"improved":[9,260],"by":[10,68,76,102,167,216,262,275,285,304,318,340,357],"better":[11],"understanding":[12],"the":[13,122,314,335,385],"molecular":[14,248],"and":[15,107,188,214,233,292],"cellular":[16],"responses":[17],"tumor":[19],"compared":[20],"to":[21,56,174,229,259,360],"normal":[22],"cells":[23,47,147,191,303,348],"after":[24,63,148,178,252],"genotoxic":[25],"insults.":[26],"Ionizing":[27],"radiation":[28],"(IR)":[29,86],"+":[30,87,277,342],"Topo":[31,52,150,179,196,204,230,242,253,278,290,307,343,371],"(e.g.,":[34],"Topotecan)":[35],"caused":[36,67,101,274,356],"synergistic":[37,98],"cell":[38,83,99,113],"killing":[39,100],"in":[40,46,112,121,128,144,184,189,212,295,311,376],"various":[41,145],"human":[42,130],"cancer":[43,146,383],"cells,":[44,384],"even":[45],"from":[48,283],"highly":[49],"radioresistant":[50],"tumors.":[51],"I":[53,90,151,180,197,231,237,243,254,279,291,308,344,372],"poisons":[54,181,280,373],"had":[55],"added":[58],"either":[59,306],"during":[60],"or":[61,309,365,374],"immediately":[62],"IR.":[64],"Synergy":[65],"was":[66,142,159,182,210,221],"DNA":[69,104,164,234],"lesion":[70,105,336],"modification":[71,106,337],"mechanisms":[72,386],"as":[73,75,329],"well":[74],"concomitant":[77],"stimulation":[78],"two":[80,126],"pathways":[81,251],"death:":[84],"necrosis":[85],"apoptosis":[88,355],"(Topo":[89],"poisons).":[91],"Cumulative":[92],"data":[93,269],"favor":[94],"a":[95,119,138,194,222,288,326,366],"mechanism":[96],"altered":[103],"enhanced":[108],"apoptosis.":[109,245],"However,":[110],"alterations":[111],"cycle":[114,352],"regulation":[115],"also":[117,270],"play":[118],"role":[120],"synergy":[123,273],"between":[124],"these":[125],"agents":[127],"certain":[129],"cancers.":[131],"We":[132],"recently":[133],"showed":[134],"that":[135,192,199,219,272],"NF-kappa":[136,156,175,207,265],"B,":[137],"known":[139],"anti-apoptotic":[140,264],"factor,":[141],"activated":[143],"poisoning":[149,232,305],"using":[152],"clinically":[153],"active":[154],"drugs.":[155,206],"B":[157,176,208,239,266],"activation":[158,177,209,220],"dependent":[160],"on":[161],"initial":[162],"nuclear":[163],"damage":[165],"followed":[166],"cytoplasmic":[168],"signaling":[169,172],"events.":[170],"Cytoplasmic":[171],"leading":[173],"diminished":[183],"cytoplasts":[185],"(lacking":[186],"nuclei)":[187],"CEM/C2":[190],"expressed":[193],"mutant":[195],"protein":[198],"did":[200],"not":[201,301],"interact":[202],"with":[203,378],"intensified":[211],"S-phase":[213],"blocked":[215],"aphidicolin,":[217],"suggesting":[218],"result":[223],"double-strand":[225],"break":[226],"formation":[227],"due":[228],"replication.":[235],"Dominant-negative":[236],"kappa":[238],"expression":[240],"augmented":[241],"poison-mediated":[244],"Elucidation":[246],"signal":[249],"transduction":[250],"drug-IR":[255],"combinations":[256],"lead":[258],"radiotherapy":[261],"blocking":[263],"responses.":[267],"Recent":[268],"indicate":[271],"IR":[276,320,341,379],"is":[281,316],"different":[282],"radiosensitization":[284],"beta-lapachone":[286],"(beta-lap),":[287],"\"reported\"":[289],"II-alpha":[293,310],"poison":[294],"vitro.":[296],"In":[297],"fact,":[298],"beta-lap":[299,346,358,375],"does":[300],"kill":[302,382],"vivo.":[312],"Instead,":[313],"compound":[315],"\"activated\"":[317],"an":[319],"(damage)-inducible":[321],"enzyme,":[322],"NAD(P)H:quinone":[323],"oxidoreductase":[324],"(NQO1),":[325],"gene":[327],"cloned":[328],"x-ray-inducible":[330],"transcript":[331],"#3,":[332],"xip3.":[333],"Unlike":[334],"pathway":[338],"induced":[339],"drugs,":[345],"kills":[347],"via":[349],"NQO1":[350],"futile":[351],"metabolism.":[353],"Downstream":[354],"appears":[359],"noncaspase-mediated,":[362],"involving":[363],"calpain":[364],"calpain-like":[367],"protease.":[368],"Thus,":[369],"although":[370],"combination":[377],"both":[380],"synergistically":[381],"are":[387],"very":[388],"different.":[389]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
