{"id":"https://openalex.org/W1974485241","doi":"https://doi.org/10.1371/journal.pone.0039216","title":"Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis","display_name":"Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis","publication_year":2012,"publication_date":"2012-06-14","ids":{"openalex":"https://openalex.org/W1974485241","doi":"https://doi.org/10.1371/journal.pone.0039216","mag":"1974485241","pmid":"https://pubmed.ncbi.nlm.nih.gov/22720079","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375234"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0039216","doi":"https://doi.org/10.1371/journal.pone.0039216","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0039216","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039216&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039216&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113536579","display_name":"Johannes Brettschneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Johannes Brettschneider","raw_affiliation_strings":["Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America. Johannes.brettschneider@uni-ulm.de","Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","Department of Neurology, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America. Johannes.brettschneider@uni-ulm.de","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Neurology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068489215","display_name":"Jon B. Toledo","orcid":"https://orcid.org/0000-0003-4366-9268","observed_orcids":["https://orcid.org/0000-0003-4366-9268"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon B. Toledo","raw_affiliation_strings":["Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041309484","display_name":"Vivianna M. Van Deerlin","orcid":"https://orcid.org/0000-0002-7400-9097","observed_orcids":["https://orcid.org/0000-0002-7400-9097"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivianna M. Van Deerlin","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084210639","display_name":"Lauren B. Elman","orcid":"https://orcid.org/0000-0003-4706-950X","observed_orcids":["https://orcid.org/0000-0003-4706-950X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Elman","raw_affiliation_strings":["Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056969742","display_name":"Leo F. McCluskey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leo McCluskey","raw_affiliation_strings":["Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065852445","display_name":"Virginia M.\u2010Y. Lee","orcid":"https://orcid.org/0000-0003-3536-6902","observed_orcids":["https://orcid.org/0000-0003-3536-6902"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia M.-Y. Lee","raw_affiliation_strings":["Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021394368","display_name":"John Q. Trojanowski","orcid":"https://orcid.org/0000-0002-9239-8794","observed_orcids":["https://orcid.org/0000-0002-9239-8794"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Q. Trojanowski","raw_affiliation_strings":["Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113536579"],"corresponding_institution_ids":["https://openalex.org/I196349391","https://openalex.org/I79576946"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":8.0842,"has_fulltext":true,"cited_by_count":264,"citation_normalized_percentile":{"value":0.98139783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"7","issue":"6","first_page":"e39216","last_page":"e39216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/upper-motor-neuron-lesion","display_name":"upper motor neuron lesion","score":0.871999979019165},{"id":"https://openalex.org/keywords/corticospinal-tract","display_name":"corticospinal tract","score":0.8830000162124634},{"id":"https://openalex.org/keywords/c9orf72-repeat-expansion","display_name":"C9orf72 repeat expansion","score":0.968999981880188},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tdp-43-pathology","display_name":"TDP-43 pathology","score":0.9390000104904175},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.8370000123977661},{"id":"https://openalex.org/keywords/axonal-loss","display_name":"axonal loss","score":0.8930000066757202},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/motor-cortex","display_name":"motor cortex","score":0.6230000257492065},{"id":"https://openalex.org/keywords/medulla","display_name":"medulla","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8770101070404053},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7183650732040405},{"id":"https://openalex.org/C2781354215","wikidata":"https://www.wikidata.org/wiki/Q3875059","display_name":"Upper motor neuron","level":4,"score":0.6624282598495483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6145110130310059},{"id":"https://openalex.org/C2777898937","wikidata":"https://www.wikidata.org/wiki/Q5008447","display_name":"C9orf72","level":5,"score":0.6118450164794922},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5026931762695312},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.49712899327278137},{"id":"https://openalex.org/C2779779279","wikidata":"https://www.wikidata.org/wiki/Q19915308","display_name":"Corticospinal tract","level":4,"score":0.46739229559898376},{"id":"https://openalex.org/C2777373429","wikidata":"https://www.wikidata.org/wiki/Q3916640","display_name":"Lower motor neuron","level":4,"score":0.458269864320755},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.44274380803108215},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27965766191482544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2126583755016327},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1527577042579651},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.12649941444396973},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.08827409148216248},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.08264905214309692},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0039216","doi":"https://doi.org/10.1371/journal.pone.0039216","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0039216","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039216&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3375234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375234","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22720079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22720079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.813.340","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.813.340","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b9/eb/pone.0039216.PMC3375234.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d486916b7f83428a8465f32cb4a2239e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d486916b7f83428a8465f32cb4a2239e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 6, p e39216 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/123952","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Microglial_Activation_Correlates_with_Disease_Progression_and_Upper_Motor_Neuron_Clinical_Symptoms_in_Amyotrophic_Lateral_Sclerosis/123952","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0039216","doi":"https://doi.org/10.1371/journal.pone.0039216","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0039216","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039216&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4300107000","display_name":"Alzheimer's Disease Core Center","funder_award_id":"P30AG010124","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4620155975","display_name":"Frontotemporal Dementias: Genotypes and Phenotypes","funder_award_id":"P01AG017586","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5521989166","display_name":null,"funder_award_id":"AG10124","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6846889","display_name":"Regulation of gene expression in frontotemporal dementia: A genome-wide approach","funder_award_id":"K08AG033101","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8821205038","display_name":"TDP-43 Proteinopathies in ALS-Dementia","funder_award_id":"P01AG032953","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000281428","display_name":null,"funder_award_id":"AG-10124","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000329697","display_name":null,"funder_award_id":"AG17586","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1974485241.pdf","grobid_xml":"https://content.openalex.org/works/W1974485241.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1539625195","https://openalex.org/W1552106782","https://openalex.org/W1965655787","https://openalex.org/W1966632052","https://openalex.org/W1967062507","https://openalex.org/W1970380641","https://openalex.org/W1970433280","https://openalex.org/W1972931472","https://openalex.org/W1974298458","https://openalex.org/W1974551350","https://openalex.org/W1974626393","https://openalex.org/W1981329326","https://openalex.org/W1986349982","https://openalex.org/W1987173022","https://openalex.org/W1988491332","https://openalex.org/W1998258821","https://openalex.org/W1999360630","https://openalex.org/W2003179114","https://openalex.org/W2003618511","https://openalex.org/W2010725749","https://openalex.org/W2011447132","https://openalex.org/W2012662246","https://openalex.org/W2016131601","https://openalex.org/W2017641062","https://openalex.org/W2019706623","https://openalex.org/W2021374516","https://openalex.org/W2026158140","https://openalex.org/W2027328104","https://openalex.org/W2033158384","https://openalex.org/W2053011315","https://openalex.org/W2053176712","https://openalex.org/W2053756212","https://openalex.org/W2054876142","https://openalex.org/W2058742494","https://openalex.org/W2062817102","https://openalex.org/W2063056677","https://openalex.org/W2066002405","https://openalex.org/W2066557327","https://openalex.org/W2072159990","https://openalex.org/W2075691498","https://openalex.org/W2076535829","https://openalex.org/W2081280332","https://openalex.org/W2082755707","https://openalex.org/W2083651501","https://openalex.org/W2090365926","https://openalex.org/W2092451107","https://openalex.org/W2095733296","https://openalex.org/W2096386031","https://openalex.org/W2107660300","https://openalex.org/W2108381339","https://openalex.org/W2112516157","https://openalex.org/W2115672510","https://openalex.org/W2117597459","https://openalex.org/W2125931517","https://openalex.org/W2130873978","https://openalex.org/W2134408741","https://openalex.org/W2137199534","https://openalex.org/W2139264742","https://openalex.org/W2140668076","https://openalex.org/W2149497936","https://openalex.org/W2150523249","https://openalex.org/W2154549928","https://openalex.org/W2154945114","https://openalex.org/W2161938104","https://openalex.org/W2165731312","https://openalex.org/W2166155593","https://openalex.org/W2167912995","https://openalex.org/W2913609543"],"related_works":["https://openalex.org/W7116441664","https://openalex.org/W7118292488","https://openalex.org/W4307762719","https://openalex.org/W4367304174","https://openalex.org/W4415143417","https://openalex.org/W2799822509","https://openalex.org/W4416168959","https://openalex.org/W2363036792","https://openalex.org/W4320922740","https://openalex.org/W4414318792"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"We":[1],"evaluated":[2],"clinicopathological":[3],"correlates":[4,179],"of":[5,21,71,98,105,160,165,177,188],"upper":[6],"motor":[7,121,158],"neuron":[8],"(UMN)":[9],"damage":[10],"in":[11,30,93,117,130,147,156,174],"amyotrophic":[12],"lateral":[13],"sclerosis":[14],"(ALS),":[15],"and":[16,52,58,87,120,183],"analyzed":[17],"if":[18],"the":[19,22,94,118,138,148,157,175],"presence":[20],"C9ORF72":[23,77,109],"repeat":[24,78,110],"expansion":[25,111],"was":[26,37,89,153],"associated":[27],"with":[28,41,76,101,108,143,162,180],"alterations":[29],"microglial":[31,115,145,172],"inflammatory":[32],"activity.":[33],"METHODS:":[34],"Microglial":[35,81],"pathology":[36,82,116,146,152,173],"assessed":[38],"by":[39,49,61,85],"IHC":[40],"2":[42],"different":[43],"antibodies":[44],"(CD68,":[45],"Iba1),":[46],"myelin":[47,53],"loss":[48,60],"Kluver-Barrera":[50],"staining":[51],"basic":[54],"protein":[55,63],"(MBP)":[56],"IHC,":[57,65],"axonal":[59],"neurofilament":[62],"(TA51)":[64],"performed":[66],"on":[67,137],"59":[68],"autopsy":[69],"cases":[70,75,100,161],"ALS":[72,99,178],"including":[73],"9":[74],"expansion.":[79],"RESULTS:":[80],"as":[83],"depicted":[84],"CD68":[86],"Iba1":[88],"significantly":[90],"more":[91,113,154],"extensive":[92,114,155],"corticospinal":[95],"tract":[96],"(CST)":[97],"a":[102,131],"rapid":[103,163],"progression":[104,164,182],"disease.":[106,166],"Cases":[107],"showed":[112],"medulla":[119],"cortex":[122,159],"which":[123],"persisted":[124],"after":[125],"adjusting":[126],"for":[127],"disease":[128,181],"duration":[129],"logistic":[132],"regression":[133],"model.":[134],"Higher":[135],"scores":[136],"clinical":[139],"UMN":[140,189],"scale":[141],"correlated":[142],"increasing":[144],"cervical":[149],"CST.":[150],"TDP-43":[151],"CONCLUSIONS:":[167],"This":[168],"study":[169],"demonstrates":[170],"that":[171],"CST":[176],"is":[184],"linked":[185],"to":[186],"severity":[187],"deficits.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}