{"id":"https://openalex.org/W1974450877","doi":"https://doi.org/10.1016/s0190-9622(89)70208-5","title":"Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin","display_name":"Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin","publication_year":1989,"publication_date":"1989-09-01","ids":{"openalex":"https://openalex.org/W1974450877","doi":"https://doi.org/10.1016/s0190-9622(89)70208-5","mag":"1974450877","pmid":"https://pubmed.ncbi.nlm.nih.gov/2674210"},"language":"en","primary_location":{"id":"doi:10.1016/s0190-9622(89)70208-5","doi":"https://doi.org/10.1016/s0190-9622(89)70208-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0190-9622(89)70208-5","pdf_url":null,"source":{"id":"https://openalex.org/S58727509","display_name":"Journal of the American Academy of Dermatology","issn_l":"0190-9622","issn":["0190-9622","1097-6787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Academy of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112774679","display_name":"Marta I. Rendon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta I. Rendon","raw_affiliation_strings":["Department of Dermatology, University of Texas Health Science Center, Dallas 75235","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Texas Health Science Center, Dallas 75235","institution_ids":["https://openalex.org/I4210094379"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047568787","display_name":"Ponciano D. Cruz","orcid":"https://orcid.org/0000-0002-1550-6149","observed_orcids":["https://orcid.org/0000-0002-1550-6149"]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ponciano D. Cruz","raw_affiliation_strings":["From the Departments of Dermatology and Internal Medicine, University of Texas Health Science Center, Dallas, Texas","Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Dermatology and Internal Medicine, University of Texas Health Science Center, Dallas, Texas","institution_ids":["https://openalex.org/I4210094379"]},{"raw_affiliation_string":"Dermatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109171744","display_name":"Richard Dennis Sontheimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Sontheimer","raw_affiliation_strings":["From the Departments of Dermatology and Internal Medicine, University of Texas Health Science Center, Dallas, Texas","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Dermatology and Internal Medicine, University of Texas Health Science Center, Dallas, Texas","institution_ids":["https://openalex.org/I4210094379"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055215832","display_name":"Paul R. Bergstresser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul R. Bergstresser","raw_affiliation_strings":["From the Departments of Dermatology and Internal Medicine, University of Texas Health Science Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Dermatology and Internal Medicine, University of Texas Health Science Center, Dallas, Texas","institution_ids":["https://openalex.org/I4210094379"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047568787"],"corresponding_institution_ids":["https://openalex.org/I4210094379"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":3.5252,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.92001608,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"21","issue":"3","first_page":"461","last_page":"469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acanthosis-nigricans","display_name":"acanthosis nigricans","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-like-growth-factor","display_name":"insulin-like growth factor","score":0.7440000176429749},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/diagnostic-algorithm","display_name":"diagnostic algorithm","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2777705978","wikidata":"https://www.wikidata.org/wiki/Q415833","display_name":"Acanthosis nigricans","level":4,"score":0.9952588677406311},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7738252878189087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7736825942993164},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5124936103820801},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.47139599919319153},{"id":"https://openalex.org/C2778478263","wikidata":"https://www.wikidata.org/wiki/Q212743","display_name":"Acanthosis","level":3,"score":0.45219525694847107},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4208085536956787},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3722972571849823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3306273818016052},{"id":"https://openalex.org/C2779915019","wikidata":"https://www.wikidata.org/wiki/Q1640998","display_name":"Hyperkeratosis","level":2,"score":0.198476642370224}],"mesh":[{"descriptor_ui":"D000052","descriptor_name":"Acanthosis Nigricans","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000052","descriptor_name":"Acanthosis Nigricans","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000052","descriptor_name":"Acanthosis Nigricans","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000052","descriptor_name":"Acanthosis Nigricans","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0190-9622(89)70208-5","doi":"https://doi.org/10.1016/s0190-9622(89)70208-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0190-9622(89)70208-5","pdf_url":null,"source":{"id":"https://openalex.org/S58727509","display_name":"Journal of the American Academy of Dermatology","issn_l":"0190-9622","issn":["0190-9622","1097-6787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Academy of Dermatology","raw_type":"journal-article"},{"id":"pmid:2674210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2674210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Academy of Dermatology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W54157561","https://openalex.org/W164140458","https://openalex.org/W1496236792","https://openalex.org/W1498198886","https://openalex.org/W1540816832","https://openalex.org/W1543535158","https://openalex.org/W1569505964","https://openalex.org/W1972831404","https://openalex.org/W1977761121","https://openalex.org/W1980354116","https://openalex.org/W1986165334","https://openalex.org/W1991367927","https://openalex.org/W1993922330","https://openalex.org/W2001680066","https://openalex.org/W2001728538","https://openalex.org/W2003772020","https://openalex.org/W2003902334","https://openalex.org/W2005971684","https://openalex.org/W2016652914","https://openalex.org/W2022901589","https://openalex.org/W2027028923","https://openalex.org/W2031212742","https://openalex.org/W2033662178","https://openalex.org/W2042209694","https://openalex.org/W2043703993","https://openalex.org/W2043802763","https://openalex.org/W2046500507","https://openalex.org/W2048233503","https://openalex.org/W2049512852","https://openalex.org/W2055496862","https://openalex.org/W2056043913","https://openalex.org/W2057383462","https://openalex.org/W2060261663","https://openalex.org/W2060650299","https://openalex.org/W2063264395","https://openalex.org/W2069521192","https://openalex.org/W2078073869","https://openalex.org/W2079530074","https://openalex.org/W2079828095","https://openalex.org/W2086362595","https://openalex.org/W2090244113","https://openalex.org/W2090990415","https://openalex.org/W2092715107","https://openalex.org/W2106234140","https://openalex.org/W2107219381","https://openalex.org/W2110833035","https://openalex.org/W2131325298","https://openalex.org/W2138834719","https://openalex.org/W2140164291","https://openalex.org/W2177335585","https://openalex.org/W2323903984","https://openalex.org/W2340100375","https://openalex.org/W2341322907","https://openalex.org/W2342729031","https://openalex.org/W2346202365","https://openalex.org/W2410300566","https://openalex.org/W2411552516","https://openalex.org/W2416784269","https://openalex.org/W2463272196","https://openalex.org/W2470605936","https://openalex.org/W4302772154"],"related_works":["https://openalex.org/W2429719927","https://openalex.org/W2064555928","https://openalex.org/W4254227319","https://openalex.org/W2079530074","https://openalex.org/W2036942890","https://openalex.org/W2075449575","https://openalex.org/W1991550165","https://openalex.org/W4302979685","https://openalex.org/W1653533986","https://openalex.org/W4211147728"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}