{"id":"https://openalex.org/W1974261663","doi":"https://doi.org/10.1097/01376517-200408000-00005","title":"Breaking Down Barriers to Treat a Patient with a Germinoma: A Case Study","display_name":"Breaking Down Barriers to Treat a Patient with a Germinoma: A Case Study","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W1974261663","doi":"https://doi.org/10.1097/01376517-200408000-00005","mag":"1974261663","pmid":"https://pubmed.ncbi.nlm.nih.gov/15366544"},"language":"en","primary_location":{"id":"doi:10.1097/01376517-200408000-00005","doi":"https://doi.org/10.1097/01376517-200408000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01376517-200408000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S81994447","display_name":"Journal of Neuroscience Nursing","issn_l":"0888-0395","issn":["0888-0395","1945-2810"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Nursing","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111761811","display_name":"Susan D. Bell","orcid":"https://orcid.org/0009-0006-1304-1487","observed_orcids":["https://orcid.org/0009-0006-1304-1487"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan Bell","raw_affiliation_strings":["The Ohio State University Medical Center and Arthur G. James and Richard J. Solove Research and Cancer Center, Columbus, OH, USA. bell-1@medctr.osu.edu","The Ohio State University Medical Center and Arthur G. James and Richard J. Solove Research and Cancer Center, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Medical Center and Arthur G. James and Richard J. Solove Research and Cancer Center, Columbus, OH, USA. bell-1@medctr.osu.edu","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I2802841970","https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University Medical Center and Arthur G. James and Richard J. Solove Research and Cancer Center, Columbus, OH, USA","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111761811"],"corresponding_institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I2802841970","https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.342,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.64697895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"36","issue":"4","first_page":"195","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.3407999873161316,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.3407999873161316,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.3303000032901764,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/germinoma","display_name":"germinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/germ-cell-tumors","display_name":"germ cell tumors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mannitol","display_name":"mannitol","score":0.8420000076293945},{"id":"https://openalex.org/keywords/intracarotid-infusion","display_name":"intracarotid infusion","score":0.8619999885559082},{"id":"https://openalex.org/keywords/intra-arterial-chemotherapy","display_name":"intra-arterial chemotherapy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neurocognitive-toxicity","display_name":"neurocognitive toxicity","score":0.5680000185966492},{"id":"https://openalex.org/keywords/radiotherapy-avoidance","display_name":"radiotherapy avoidance","score":0.6549999713897705},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.7059999704360962},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7961505651473999},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7407882809638977},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.5784465670585632},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5515838861465454},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5420968532562256},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5377412438392639},{"id":"https://openalex.org/C2778895204","wikidata":"https://www.wikidata.org/wiki/Q950838","display_name":"Germinoma","level":3,"score":0.5029968619346619},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34685972332954407},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34583115577697754},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3317010998725891},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32821395993232727},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2702403664588928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26967406272888184},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2110048234462738},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.08715793490409851},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018237","descriptor_name":"Germinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018237","descriptor_name":"Germinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018237","descriptor_name":"Germinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01376517-200408000-00005","doi":"https://doi.org/10.1097/01376517-200408000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01376517-200408000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S81994447","display_name":"Journal of Neuroscience Nursing","issn_l":"0888-0395","issn":["0888-0395","1945-2810"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Nursing","raw_type":"journal-article"},{"id":"pmid:15366544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15366544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8500000238418579,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3185423717","https://openalex.org/W2560983496","https://openalex.org/W2011260154","https://openalex.org/W2277826541","https://openalex.org/W2414069397","https://openalex.org/W2315917474","https://openalex.org/W2392040747","https://openalex.org/W2127755477","https://openalex.org/W1475314046","https://openalex.org/W2082803429"],"abstract_inverted_index":{"Germinomas":[0],"are":[1],"the":[2,13,20,39,48,65,71,91,98,103,146,149],"most":[3],"common":[4],"type":[5],"of":[6,16,19,22,50,93,97,120],"germ":[7],"cell":[8],"tumor":[9,147,152],"occurring":[10],"commonly":[11],"before":[12],"second":[14],"decade":[15],"life.":[17],"Because":[18],"radiosensitivity":[21],"germinomas,":[23],"traditional":[24],"treatment":[25],"following":[26],"diagnosis":[27],"has":[28,43,63,80],"been":[29,64],"conventional":[30],"radiotherapy.":[31],"The":[32,75,122],"desire":[33],"to":[34,37,46,67,145],"defer":[35],"radiotherapy":[36],"avoid":[38],"delayed":[40],"neurocognitive":[41],"effects":[42],"led":[44],"researchers":[45],"investigate":[47],"use":[49,92],"up":[51],"front":[52],"chemotherapy.":[53,132],"A":[54],"major":[55],"limitation":[56],"in":[57,136],"using":[58],"chemotherapy":[59,82,135],"for":[60,84],"brain":[61,73,77,88,100,140,150],"tumors":[62,89],"inability":[66],"deliver":[68],"drugs":[69],"across":[70],"blood":[72,76,99,139],"barrier.":[74,101],"barrier":[78,141],"consortium":[79],"developed":[81],"protocols":[83],"patients":[85],"with":[86,138],"malignant":[87],"through":[90],"reversible":[94],"osmotic":[95,109],"opening":[96,110],"While":[102],"patient":[104],"is":[105,113,125,153],"under":[106],"general":[107],"anesthesia,":[108],"or":[111],"disruption":[112],"achieved":[114],"by":[115,127],"a":[116],"30-second":[117],"intracarotid":[118],"infusion":[119,124],"mannitol.":[121],"mannitol":[123],"followed":[126],"both":[128],"intraarterial":[129],"and":[130,148],"intravenous":[131],"By":[133],"administering":[134],"conjunction":[137],"disruption,":[142],"drug":[143],"delivery":[144],"around":[151],"increased.":[154]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
