{"id":"https://openalex.org/W1974040320","doi":"https://doi.org/10.1016/s0016-5085(14)61768-6","title":"Su1879 SIRT1 Antagonizes Distinct Effects of TNF-\u03b1 on Intestinal Epithelial Barrier","display_name":"Su1879 SIRT1 Antagonizes Distinct Effects of TNF-\u03b1 on Intestinal Epithelial Barrier","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W1974040320","doi":"https://doi.org/10.1016/s0016-5085(14)61768-6","mag":"1974040320"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(14)61768-6","doi":"https://doi.org/10.1016/s0016-5085(14)61768-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(14)61768-6","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075152791","display_name":"Yuanhang Ma","orcid":"https://orcid.org/0000-0001-6830-7189","observed_orcids":["https://orcid.org/0000-0001-6830-7189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanhang Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077866571","display_name":"Guoqing Chen","orcid":"https://orcid.org/0000-0002-3671-5257","observed_orcids":["https://orcid.org/0000-0002-3671-5257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guoqing Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Weidong Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weidong Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101682015","display_name":"Lihua Sun","orcid":"https://orcid.org/0000-0002-0888-7991","observed_orcids":["https://orcid.org/0000-0002-0888-7991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lihua Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021592376","display_name":"Songwei Yang","orcid":"https://orcid.org/0000-0003-4040-1215","observed_orcids":["https://orcid.org/0000-0003-4040-1215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Songwei Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Min Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101940097","display_name":"Yuan Qiu","orcid":"https://orcid.org/0000-0002-8997-4367","observed_orcids":["https://orcid.org/0000-0002-8997-4367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Qiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072237935","display_name":"Chao Xu","orcid":"https://orcid.org/0000-0002-3821-6187","observed_orcids":["https://orcid.org/0000-0002-3821-6187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082728029","display_name":"Peng Ke","orcid":"https://orcid.org/0000-0002-4094-6322","observed_orcids":["https://orcid.org/0000-0002-4094-6322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ke Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063058727","display_name":"Ligang Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ligang Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083316663","display_name":"Hua Yang","orcid":"https://orcid.org/0000-0002-8999-7147","observed_orcids":["https://orcid.org/0000-0002-8999-7147"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":"5","first_page":"S","last_page":"492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/intestinal-epithelial-barrier","display_name":"intestinal epithelial barrier","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.718999981880188},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/claudin-1","display_name":"claudin-1","score":1.0},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/intestinal-epithelial-injury","display_name":"intestinal epithelial damage","score":0.7649999856948853},{"id":"https://openalex.org/keywords/os-9","display_name":"OS-9","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.9382426738739014},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.8961187601089478},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.8064897060394287},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.7169944643974304},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6595713496208191},{"id":"https://openalex.org/C51872919","wikidata":"https://www.wikidata.org/wiki/Q420863","display_name":"Claudin","level":3,"score":0.657128095626831},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.58623206615448},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5337475538253784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4983811378479004},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.49196574091911316},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42753511667251587},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3870127499103546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36510026454925537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3159206211566925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2564282715320587},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24541935324668884},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1851758360862732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12337076663970947},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0016-5085(14)61768-6","doi":"https://doi.org/10.1016/s0016-5085(14)61768-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(14)61768-6","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2112992034","https://openalex.org/W2090045636","https://openalex.org/W2187196499","https://openalex.org/W3028985600","https://openalex.org/W1569109807","https://openalex.org/W2110174748","https://openalex.org/W3018749295","https://openalex.org/W4252615954","https://openalex.org/W2027254333","https://openalex.org/W1726855813"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}